The present invention relates to a method for detecting a target analyte using a gold nanoparticle, comprising growing a copper crystal specifically on a gold nanoparticle by treating the gold nanoparticle with a solution comprising a copper ion, a polymer having a primary or secondary amine group, and a reducing agent, a composition for amplifying a signal used in the detection method above, and a kit for detecting a target analyte comprising the composition for amplifying a signal above.

The present application provides certain advantageous ways of conducting multiplexed imaging.

The techniques and systems described herein relate to manufacturing, characterizing, and/or identifying one or more types of magnetic nanowires (MNWs). One or more types of MNWs may be associated with different objects, and a system may identify the objects based on the magnetic nanowires associated with the objects. For example, such techniques may involve characterizing the types of MNWs based on magnetic field transmission characteristics and ferromagnetic resonance characteristics of each type of MNW. In some examples, the techniques described herein may enable the identification of each of a plurality of types of MNWs present in a sample or object based on a combined transmission value of the sample. Such techniques may enable the development and use of barcode-like systems of different types of MNWs for labeling and identifying objects of interest.

Methods are herein described which reduce the non-specific light scattering background from polymeric microspheres in aqueous suspension to a level where individual metal or metal-like plasmonic nanoparticles that have been chemically bound to the surface of individual polymeric microspheres can be imaged by high resolution optics and enumerated by image analysis software. The non-specific light scattering background is reduced by employing aqueous-miscible solvents to remove residual water at the microsphere surfaces and resuspending the microspheres in a fluid having a refractive index substantially similar to the refractive index of polymeric microspheres. Embodiments of the method disclosed herein enable sensitive quantitative assays for ligand receptor binding, antigen antibody binding and nucleic acid hybridization binding. The embodiments disclosed herein further may employ polystyrene microspheres and gold plasmonic nanoparticles.

The present disclosure relates to methods and products associated with in vitro and in vivo protease activity measurements and enzyme profiling. Some aspects of the present disclosure relate to measuring remotely triggered protease activity. In particular, the disclosure relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence or absence of active enzymes associated with disease or conditions. The disclosure also relates to products, kits, and databases for use in the methods of the disclosure.

A method for analyzing or detecting methimazole (“MTZ”) comprising contacting a sample suspected of containing MTZ with the dendrimer-stabilized silver nanoparticles and performing surface-enhanced Raman scattering (SERS). Graphene-dendrimer-stabilized silver nanoparticles (G-D-Ag).

The techniques and systems described herein relate to manufacturing, characterizing, and/or identifying one or more types of magnetic nanowires (MNWs). One or more types of MNWs may be associated with different objects, and a system may identify the objects based on the magnetic nanowires associated with the objects. For example, such techniques may involve characterizing the types of MNWs based on magnetic field transmission characteristics and ferromagnetic resonance characteristics of each type of MNW. In some examples, the techniques described herein may enable the identification of each of a plurality of types of MNWs present in a sample or object based on a combined transmission value of the sample. Such techniques may enable the development and use of barcode-like systems of different types of MNWs for labeling and identifying objects of interest.

A method for analyzing or detecting methimazole (“MTZ”) comprising contacting a sample suspected of containing MTZ with the dendrimer-stabilized silver nanoparticles and performing surface-enhanced Raman scattering (SERS). Graphene-dendrimer-stabilized silver nanoparticles (G-D-Ag).

Surface modified particles have a core, an inner shell and an outer shell. The core is formed of silica or is hollow, the inner shell is formed by a layer of metal, and the outer shell is formed by a biocompatible polymer brush. The particles allow for direct optical detection of biomolecules such as nucleic acids, proteins, polysaccharides and glycoproteins in biological samples.

The present invention provides novel gold nanoclusters, a dopamine biosensor including the same that may exhibit reliability in a wide detection range, and a method of quantifying dopamine using the same, and provides a method of diagnosing a neurological disease that exhibits high selectivity for dopamine using the gold nanoclusters. In addition, the present invention provides a method of concentrating glycoproteins that may exhibit improved concentration efficiency and minimize non-specific binding using the gold nanoclusters. A method of analyzing disease-specific glycoproteins which includes the method of concentrating glycoproteins using the gold nanoclusters may be easily used for diagnosis of a disease by identifying different glycoproteins in a patient group compared to a normal group.