The present invention provides compositions and methods for targeting cells for therapeutic and/or diagnostic purposes, e.g., delivery of therapeutic and/or diagnostic agents to a cell. Nanoparticles and polymers functionalized with capture molecules, reporter molecules, and/or therapeutic agents are provided for the treatment or prevention of disease, including neurological diseases associated with neuroinflammation, and cancer.

The present invention provides a fluorescent polymer comprising a fluorophore perylene bisimide (PBI) and oligo (p-phenylene vinylene) (OPV) functionalized with carboxy and amine functionality groups and a polystyrene (PS) backbone for the detection of volatile organic compound, a process for the detection and a kit thereof.

The present disclosure relates generally to compositions and methods for high capacity detection of biological samples. Multiple optical labels as well as their combinations, which may include different ratios of the optical labels, can be used to allow detection of a large number of target molecules, cells, or tissues.

This disclosure generally describes to products and compositions relating to a modified Interferometric Reflectance Imaging Sensor (IRIS) platform, wherein said modification relates to, among other things, one or more of a fluidics pathway, a cassette housing for a chip cartridge, a diluted biological specimen and properly labeled gold nanoparticles observed in a wide field-of-view (i.e., not single nanoparticle counting). The present disclosure also includes products and methods that may be used separately or together with the modified IRIS platform, including one or more of a chip spotted with a unique population of purpose-specific test materials, the test materials themselves, a chip cartridge casing, and compositions for use in a fluidics pathway. As contemplated herein, the products and methods disclosed herein may be used for myriad applications, including assessment of overall health, immune profiling abnormal health conditions, including infections and diseases, such as cancer, etc. Data generated by the products and processes described herein may also be suitable for use with automated analysis including typical machine learning tools.

A sensor can include a nanostructure in a housing configured to contact a sample.

A surface enhanced Raman scattering device includes a substrate including a substrate surface having a substrate surface energy; a modulation layer formed on the substrate surface and including a modulation layer surface having a modulation layer surface energy; and a surface enhanced Raman scattering structure formed on the modulation layer surface. The modulation layer surface energy is less than the substrate surface energy. A method of manufacturing the surface enhanced Raman scattering device is also provided.

A single unit, handheld field portable apparatus and method for analyzing Ochratoxin A (OTA) in rice quality monitoring, based on fluorescence signal output. Aliquots may be analyzed by adding at least one or more reagents to the sample aliquot that reacts selectively with an analyte contained therein. The reaction product, which is selective for the analyte of interest and proportional to its concentration, is measured with an appropriate detector. This enables simple and accurate testing of samples using time honored wet-chemical analysis method in microliter volume regimes while producing remarkably small volumes of waste. The device includes a multipurpose controller board for processing and analysis purpose, a camera which is integrated with the controller, a resistive touch liquid crystal display to view the results, a light emitting diode to emit the UV light, and a power bank. The device may operate using a touch display.

The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.

The present invention relates to a plasmonic biosensor system. The system includes a nano-hole array device comprising at least one nano-hole array (NHA) including at least one or a plurality of nano holes (NH), an image sensor (A3) for capturing light provided by a light source (A1) and transmitted through the nano-hole array (NHA), and at least one or a plurality of nano-particles (NP) configured to be received by the nano-holes (NH) of the nano-hole array (NHA).

A single electron transistor conjugated to a bacteriophage form a detectable probe where an RF signal identify the location of such probe at the site of specific biological matrix and provide a unique electronic signal such as a Coulomb Staircase and where such signal act as a diagnostic beacon and where such probe and a detector form a mesoscopic detector. The detector uses: a bioprobe containing the phage with its conjugated SET and the properties of the phage specificity; phage mobility within the biological environment and the phage ability to act as a carrier for the SET; and the SET's ultimate use as a beacon for the detection.