Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.

Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.

Injectable compositions for the MRI detection of an analyte selected from the group consisting of reactive oxygen species, proteases and enzymes, comprising a) a matrix material based on a responsive hydrophobic polymer capable of undergoing a chemical reaction with the analyte to be detected, such reaction leading to a disruption of the polymer chain of the responsive polymer, b) a contrast agent suitable for use in magnetic resonance imaging, embedded in or encapsulated in the polymer a), c) optionally, a functionality capable of binding a marker or probe or a probe for creating a second detection signal, and d) optionally, a non-responsive polymer not undergoing a chemical reaction with the analyte under the conditions where polymer a) undergoes a reaction leading to chain breakage

An example compound according to an example of the present disclosure includes, among other possible things, a nanotube carrier, a moiety, a linker having first and second functional groups, wherein the first functional group is covalently linked to the nanotube carrier, and the second functional group is covalently linked to the moiety. An example method of making a nanotube compound according to the present disclosure is also disclosed.

The present invention provides a method for increasing the sensitivity of LFIAs by using palladium nanoparticles, selecting appropriate dye chemistries, and improving the timing of the development chemistry. In the presence of a palladium nanoparticle, three reagents interact with a catalytic label to form a colored dye. The three reagents include a hydrogen peroxide source, a color developer (a substituted para-phenylenediamine), and a color coupler (e.g. a napthol or a phenol). The timing of the development chemistry is improved by any combination of using a reducing agent, delaying hydrogen peroxide application by diffusion, using dissolving materials as a time delay, using serpentine flow, and separating the color coupler and the color developer on the strip.

The present invention relates to methods for the detection of an analyte, such as coronavirus (e.g. SARS-CoV-2) or other virus particles and proteins, in a test sample. The invention also provides a flow device for use in such methods. Additionally, there is provided a coronavirus-binding reagent having the structure [sialic acid]-[linker]-[polymer]-[gold nanoparticle] for use in the devices and methods of the invention.

The present invention pertains to the field of pre-functionalised nanoparticles (NPs). It relates more particularly to NPs pre functionalized using a self-assembled monolayer (SAM) and also to NPs functionalized using biomolecules such that the NPs are stable in solution. These NPs may be used in numerous applications, especially as a diagnostic tool, tool for depleting a molecule of interest in a solution, and therapeutic tool.

This invention is a functionalized diamond crystal with high dispersibility in high ionic strength solution and/or with specific targeting ability, which comprise a diamond crystal and a fatty acid layer. The fatty acid layer works a surfactant and provides a specific targeting feature for the diamond crystal. The feature of the surfactant makes the diamond crystal being easily dispersed in biological surrounding (e.g., phosphate saline buffer) and the feature of specific targeting ability provides the diamond crystal with specific recognizing specific targets. This invention allows researchers to use diamond crystal as a marker for specific labelling.

A single electron transistor conjugated to a bacteriophage form a detectable probe where an RF signal identify the location of such probe at the site of specific biological matrix and provide a unique electronic signal such as a Coulomb Staircase and where such signal act as a diagnostic beacon and where such probe and a detector form a mesoscopic detector. The detector uses: a bioprobe containing the phage with its conjugated SET and the properties of the phage specificity; phage mobility within the biological environment and the phage ability to act as a carrier for the SET; and the SET's ultimate use as a beacon for the detection.

An object of the invention is to provide a detection reagent which can detect human metapneumovirus in an actual analyte with an excellent sensitivity. The invention relates to a human metapneumovirus detection reagent characterized by containing an antibody which recognizes the matrix protein of human metapneumovirus, an immunological assay for human metapneumovirus including detecting human metapneumovirus in an analyte with an antibody which recognizes the matrix protein of human metapneumovirus and the like.