The purpose of the present invention is to provide: an artificial bio sensor that is easy to produce and that exhibits superior specificity; and a method for producing same. Nanoparticles according to the present invention for sensing use comprise a molecular imprint polymer having a molecular imprint space for biological matter. The molecular imprint polymer includes a structural unit derived from functional groups including an interaction group with respect to said biological matter and a signaling substance binding group different from said interaction group. The functional groups are present on the surface of the molecular imprint space. The nanoparticles are useful as an artificial biosensor that is easy to produce and exhibits superior specificity.

Provided herein are compositions and methods for determining the structure of individual targets by determining long-range distances within such targets.

The present invention relates to lateral flow assay devices adapted to detect IgA specific for SARS-CoV-2 in biological samples from subjects suspected to have COVID-19, and methods of using the lateral flow assay devices.

The present invention relates to a nanoscreen for regulating stem cell adhesion and differentiation. Moreover, the present invention relates to a method of regulating stem cell adhesion and differentiation using the nanoscreen. According to the nanoscreen of the present invention and the method of regulating stem cell adhesion and differentiation using the same, it is possible to efficiently regulate stem cell adhesion and differentiation by applying a magnetic field to the nanoscreen.

Disclosed are a one-pot biosensor and an immunoassay method using the same. The one-pot biosensor includes a photocatalyst substrate deposited with metal nanoparticles; and a reaction pad which is disposed on an upper surface of the photocatalyst substrate and includes a first binding material-fluorescent material complex specifically binding to a molecule to be detected, and the immunoassay method using the same. The one-pot biosensor may detect a target by once solution injection and has a size enough to be portable. Accordingly, since the one-pot biosensor can detect the target by only once solution injection without a washing step, because of a sensor platform capable of being easily used by an individual other than a diagnostic expert, it is predicted to be positioned as a means capable of confirming the health condition of the individual without seeing the doctor, such as a pregnancy diagnostic kit which has been currently commercialized.

A lateral flow assay and compositions for performing such an assay are described herein that detect whole virus (e.g., HIV, HCV, HSV-2) or viral proteins that use the broad-spectrum anti-viral lectin, griffisthin (GRFT), conjugated to polymeric or gold nanoparticles (NPs) and an appropriate monoclonal antibody (mAb) to confer virus selectivity.

The present invention relates to a method for separating biomolecules from a liquid medium. The method comprises adding magnetic nanoparticles to the liquid medium comprising the biomolecules, the biomolecules each adapted to bind to respective surfaces of the magnetic nanoparticles; bringing the liquid medium to which the magnetic nanoparticles have been added into contact with a collector; applying a magnetic field to the liquid medium in contact with the collector to attract the magnetic nanoparticles ound with the biomolecules to a surface of the collector; and applying an electric potential to the surface of the collector to release the biomolecules from the magnetic nanoparticles.

Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

The present disclosure provides a digital microfluidic (DMF) cartridge for performing a self-test for a target analyte, including a DMF cartridge comprising a bottom substrate and a top substrate separated by a droplet operations gap, wherein the bottom substrate comprises a plurality of droplet operations electrodes configured for performing droplet operations on a liquid droplet in the droplet operations gap; one or more reaction chambers or reaction zones on the bottom substrate that are supplied by an arrangement of the droplet operations electrodes, wherein each reaction chamber or reaction zone comprises at least one detection spot and is configured for performing a plasmonic particle-assisted ELISA (pELISA) for detection and quantification of a target analyte in a sample droplet. The device may include downloadable software for a self-test and be operable using a smart device.

Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the absence of the target.