Provided is a carrier which has excellent pressure resistance, and even when a protein ligand is not immobilized thereon, has a high dynamic binding capacity to a target substance, and has a high performance of separating a target substance from a biological sample.

The carrier includes a polymer having a crosslinked structure containing a divalent group represented by the following Formula (1):

##STR00001## wherein R.sup.1 to R.sup.4 independently represent a single bond or a divalent hydrocarbon group, R.sup.5 and R.sup.6 independently represent a hydrogen atom or a hydrocarbon group, X represents a thio group, a sulfinyl group, a sulfonyl group, an oxy group, >N(—R.sup.31), >Si(—R.sup.32).sub.2, >P(—R.sup.33), >P(═O)(—R.sup.34), >B(—R.sup.35), or >C(—R.sup.36).sub.2 (R.sup.31 to R.sup.36 independently represent a hydrogen atom or hydrocarbon group), and * represents a bond, with a proviso that when both R.sup.1 and R.sup.3 are a divalent hydrocarbon group, R.sup.1 and R.sup.3 may form a ring together with an adjacent carbon atom, and when both R.sup.2 and R.sup.4 are a divalent hydrocarbon group, R.sup.2 and R.sup.4 may form a ring together with an adjacent carbon atom.

This resin-platinum composite 100 is provided with resin particles 10 and platinum particles 20, and the platinum particles 20 are immobilized on the resin particles 10. In the resin-platinum composite 100, one portion of the platinum particles 20 may be distributed three-dimensionally on surface layer sections 60 of the resin particles 10. In this case, the one portion of the three-dimensionally distributed platinum particles 20 may be partially exposed outside the resin particles 10, and the remaining portion may be enclosed in the resin particles 10. In the platinum particles 20, enclosed particles 30 that are fully enclosed in the resin particles 10, partially exposed particles 40 each having a segment embedded inside the resin particles 10 and a segment exposed outside the resin particles 10, and surface attached particles 50 attached to the surfaces of the resin particles 10 preferably exist.

This resin-platinum composite 100 is provided with resin particles 10 and platinum particles 20, and the platinum particles 20 are immobilized on the resin particles 10. In the resin-platinum composite 100, one portion of the platinum particles 20 may be distributed three-dimensionally on surface layer sections 60 of the resin particles 10. In this case, the one portion of the three-dimensionally distributed platinum particles 20 may be partially exposed outside the resin particles 10, and the remaining portion may be enclosed in the resin particles 10. In the platinum particles 20, enclosed particles 30 that are fully enclosed in the resin particles 10, partially exposed particles 40 each having a segment embedded inside the resin particles 10 and a segment exposed outside the resin particles 10, and surface attached particles 50 attached to the surfaces of the resin particles 10 preferably exist.

Compositions comprising multiple hydrogel particles having substantially the same diameter, but with each subgrouping of particles from the multiple hydrogel particles having different associated values for one or more passive optical properties that can be deconvoluted using cytometric instrumentation. Each hydrogel particle from the multiple hydrogel particles can be functionalized with a different biochemical or chemical target from a set of targets. A method of preparing hydrogel particles includes forming droplets and polymerizing the droplets, with optional functionalization.

In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. Assay reagents and analytes may be incorporated within the microfluidic capture structures.

In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. Assay reagents and analytes may be incorporated within the microfluidic capture structures.

Disclosed herein are compositions comprising beads with unique analog code identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.

Disclosed herein are compositions comprising beads with unique analog code identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.

The present disclosure provides a biosensor having improved sensitivity. The present disclosure also provides a base material for manufacturing a sensor for analyzing a detection object, said base material comprising a molecularly imprinted polymer having: a molecularly imprinted recess in which a target of the detection object is received; and a group for binding a specific bondable molecule to the target, said group being provided inside the molecularly imprinted recess. The base material is characterized in that the group for binding the specific bondable molecule is a group suited for a small substance, and/or is characterized in that the molecularly imprinted recess has a shape or structure suited for a small substance.

The present disclosure provides a biosensor having improved sensitivity. The present disclosure also provides a base material for manufacturing a sensor for analyzing a detection object, said base material comprising a molecularly imprinted polymer having: a molecularly imprinted recess in which a target of the detection object is received; and a group for binding a specific bondable molecule to the target, said group being provided inside the molecularly imprinted recess. The base material is characterized in that the group for binding the specific bondable molecule is a group suited for a small substance, and/or is characterized in that the molecularly imprinted recess has a shape or structure suited for a small substance.