Provided is a magnetic particle having high magnetic field responsiveness in detection of a substance to be measured, such as an antigen or an antibody, from a specimen. The magnetic particle includes a magnetic core particle and a polymer layer arranged on a surface of the magnetic core particle. The magnetic core particle contains an aggregation of a plurality of magnetic nanoparticles. The polymer layer contains a polymer having at least one kind of functional group selected from the group consisting of: a carboxyl group; an amino group; a thiol group; an epoxy group; a maleimide group; and a succinimidyl group.

Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a housing including an internal area, a container configured to hold a fluid sample at a sample position in a light tight manner within the internal area of the housing, a light source configured to project light onto the fluid sample within the container, and an optical sensor configured to move between different sensor positions while the fluid sample remains stationary at the sample position, the different sensor positions including at least two of: (i) a first sensor position for taking a luminescence reading of the fluid sample; (ii) a second sensor position for taking a dark current or other background measurement; and (iii) a third sensor position for taking a fluorescence reading of the fluid sample.

The present disclosure provides a modified particle in which deterioration of a specific binding substance fixed to the surface of the particle is reduced. The modified particle according to the present disclosure contains a particle, a specific binding substance that has a property of specifically binding to an analyte and that has been fixed to the surface of the particle, and an amino sugar molecule fixed to the surface of the particle with an amide bond.

Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction, for example wherein the determination involves a complex sample, are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a complex sample including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.

The present invention relates to a magnetic-optical composite nanostructure, which has a heterogeneous nature due to consisting of a first core-shell nanoparticle and second core-shell nanoparticles and thus realizes magnetic and optical functions at the same time.

Nanorod devices for isolating and characterizing target cellular components are provided. Methods of isolating, detecting, and/or characterizing the components are also provided. Methods of use and treatment are further disclosed, such as treating diseases identified using the nanorods and/or using differentiated stem cells identified using the provided nanorods.

An object of the present invention is to provide a composite particle for an immunochromatography which has excellent spreadability, a method for manufacturing the same, and an immunochromatography using the composite particle for an immunochromatography. A composite particle for an immunochromatography of the present invention is a composite particle for an immunochromatography in which magnetic particles having an average particle size of 500 nm or less and gold particles having an average particle size of 500 nm or less are bound via an organic substance.

A method for forming a conjugate of a substance of interest and a magnetic particle to which a specific binding substance that has an ability to specifically bind to the substance of interest has been bound, the method including (A1) reacting the substance of interest and the magnetic particles in a reaction solution, in which (A1) includes increasing momentum of the magnetic particles in the reaction solution by changing the magnetic field that is exerted on the magnetic particles.

The invention is in the field of in vitro diagnostics and relates to a method for quantitatively determining therapeutic TNF-alpha inhibitors.

The present application is directed to a composite material comprising a core that is responsive to a magnet or a magnetic field, surrounded by a polymer that has been chemically modified to spontaneously bind and assemble a dense corona of fluorescent quantum dots, which is then over-coated with another layer of modified polymer that can be bound by an antibody complex for targeting specific antigens. Methods of preparing and using this material for the detection and quantification of target antigens is also included in the application.