An absorbable iron-based instrument is provided having an iron-based substrate, a zinc-containing protector in contact with the iron-based substrate, and a degradable polyester in contact with the iron-based substrate and/or the zinc-containing protector. The range of the ratio of the mass of the zinc-containing protector to the mass of the iron-based substrate is 1:200 to 1:2. In the degradable polyester, the mass fraction of a low-molecular-weight part with a molecular weight of less than 10,000 is less than or equal to 5%; alternatively, in the degradable polyester, the mass fraction of a residual monomer is less than or equal to 2%.

An absorbable iron-based alloy implantable medical device includes an iron-based alloy matrix, a degradable polymer coating disposed on the surface of the iron-based alloy matrix, and a corrosion inhibition layer disposed on the surface of the iron-based alloy matrix. The corrosion inhibition layer can delay early-stage corrosion of the iron-based alloy matrix, ensure mechanical performance of a medical device in the early stage of the implantation, prevent degradation of a polymer in the early stage of the implantation of the medical device, and reduce the usage of the degradable polymer, thereby reducing risks of inflammatory reactions.

A method is disclosed for coating surfaces that are unreactive or of low reactivity toward an inorganic alkoxide, in order to modify surface properties. The surface is activated by oxidation or amination to produce reactive functionality on the surface, followed by chemical reaction with an inorganic alkoxide to form an inorganic adhesion layer on the surface. This adhesion layer transforms the surface into one that reacts readily with a phosphonic acid that can then be used to impart hydrophobic or cell-adhesive properties to the surface or that can be transformed to attach bioactive substrates through metal-catalyzed coupling procedures. The adhesion layer can serve to bond directly with other organics that are reactive toward such metal oxides. Also disclosed are coated surfaces and constructs comprising the coated surfaces.

The invention relates to the field of medicine and medical technology, namely to bone implants, and can be used in surgery, orthopedics, dentistry. Bone implants made of dense tough fibrous or fine-crystal silicate mineral aggregate or rock, jade, have high strength, resistance to crack formation, biological compatibility and the ability to integrate into bone tissue. The technical resultexpanding the field of medical devices for implantation into bone tissue.

In alternative embodiments, provided are products of manufacture such as medical or dental devices, e.g., bone implants, having zinc phosphate (ZnP) coatings prepared on zinc (Zn), magnesium (Mg), and iron (Fe) based biodegradable metals and other non-biodegradable substrates, e.g., stainless steel, titanium and its alloys, cobalt-chrome alloys, nickel titanium alloys, to improve surface biocompatibility and provide antibacterial properties, and to enhance vascularization, and methods of making and using them. In alternative embodiments, also provided are methods to form ZnP coatings, including ZnP coatings with a porous surface, on metal surfaces such as zinc surfaces, and Zn-, Mg-, and Fe-based biodegradable metals, and other non-biodegradable substrates.

The invention provides medical devices comprising high-strength alloys which degrade over time in the body of a human or animal, at controlled degradation rates, without generating emboli and which have enhanced degradation due to the presence of a halogen component. In one embodiment the alloy is formed into a bone fixation device such as an anchor, screw, plate, support or rod. In another embodiment the alloy is formed into a tissue fastening device such as staple. In yet another embodiment, the alloy is formed into a dental implant or a stent.

Provided are an iron-based absorbable and implantable medical device and manufacturing method thereof. The iron-based absorbable and implantable medical device (1) comprises a substrate (11), a degradable polymer layer (12), and an anionic surfactant layer (13) located between the substrate (11) and the degradable polymer layer (12). The anionic surfactant, by using the hydrophobicity thereof, can form a hydrophobic barrier layer in a solution to isolate a surface of the iron-based substrate (11) from a body fluid environment, thereby avoiding direct contact with an acidic environment resulting from degradation of the degradable polymer layer (12) at the initial and early stages of implantation, thus preventing severe local corrosion of the iron-based substrate (11).

A medical device at least partially formed of a metal alloy of duplex steel.

The present invention is directed to a biodegradable alloy suitable for use in a medical implant, comprising at least 50% iron by weight, at least 25% manganese by weight, and at least 0.01% sulfur and/or selenium by weight, wherein the biodegradable alloy is nonmagnetic. The present invention also provides a method of producing a biodegradable alloy with a desirable degradation rate.

The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.