The present invention provides a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein an antioxidant compound selected from the group of flavonoids or methoxytryptophols, an ester thereof, a pharmaceutically acceptable salt thereof or a combination thereof, is/are coated to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. This implant is useful for replace bone tissue in vertebrate animals, and furthermore restore the normal function of said tissue, mainly due to its ability of induce osseointegration and soft tissue attachment.

Proposed is a hybrid ceramic prosthesis. Since the prosthesis is made of a novel hybrid ceramic material, the prothesis has a similar color and transmittance to natural teeth, minimizes tooth removal during preparation for placement of the prothesis, is securely attached to the target tooth by snap-fit fastening to prevent detachment of the prothesis and re-treatment caused by the prothesis detachment, and can be more conveniently applied to the patient than conventional prostheses, enabling an one-day-one-stop dental procedure, thereby reducing burden to patients. The prothesis is useful as a primary crown.

Proposed is a hybrid ceramic prosthesis. Since the prosthesis is made of a novel hybrid ceramic material, the prothesis has a similar color and transmittance to natural teeth, minimizes tooth removal during preparation for placement of the prothesis, is securely attached to the target tooth by snap-fit fastening to prevent detachment of the prothesis and re-treatment caused by the prothesis detachment, and can be more conveniently applied to the patient than conventional prostheses, enabling an one-day-one-stop dental procedure, thereby reducing burden to patients. The prothesis is useful as a primary crown.

A method of implanting a medical implant comprises the steps of reaming a tapered bore to a first depth and a counter bore, coaxial to the tapered bore, to a second depth less than the first depth in a long bone. The counter bore has a larger diameter than the tapered bore. The method further includes inserting a medical implant into the tapered bore and counter bore. The medical implant includes a stem and a collar disposed around a portion of the stem. Inserting the medical implant include fully seating a portion of the stem into the tapered bore to form a press-fit between the stem and the long bone. The collar may be moved into the counter bore to a depth less than the second depth.

A method of implanting a medical implant comprises the steps of reaming a tapered bore to a first depth and a counter bore, coaxial to the tapered bore, to a second depth less than the first depth in a long bone. The counter bore has a larger diameter than the tapered bore. The method further includes inserting a medical implant into the tapered bore and counter bore. The medical implant includes a stem and a collar disposed around a portion of the stem. Inserting the medical implant include fully seating a portion of the stem into the tapered bore to form a press-fit between the stem and the long bone. The collar may be moved into the counter bore to a depth less than the second depth.

A process for manufacturing a cap (4) which has at least one nominal breaking point (16) of a covering device for a bone defect site (2) and a device (1) for covering and/or reconstructing a bone defect site (2) are proposed, wherein through comparing a first data set which represents the affected bone defect site (2) in the actual condition with a second data set which represents the nominal condition of a regenerated bone at the bone defect site (2), wherein the second data set has been calculated or recorded at a time at which the bone at the site now to be regenerated was still a healthy bone (18) it is made possible that the regenerated bone produced through the regeneration of the bone defect point (2) has a shape which corresponds to the shape the bone had at the site to be regenerated when it was still healthy.

A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.

Thin-film mesh for medical devices, including stent and scaffold devices, and related methods are provided. Micropatterned thin-film mesh, such as thin-film Nitinol (TFN) mesh, may be fabricated via sputter deposition on a micropatterned wafer. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh used as a cover for a stent device. The stent device may include two stent modules that may be implanted at a bifurcated aneurysm such that one module passes through a medial surface of the other module. The thin-film mesh may include pores with complex, fractal, or fractal-like shapes. The thin-film mesh may be used as a scaffold for a scaffold device. The thin-film scaffold may be placed in a solution including structural protein such as fibrin, seeded with cells, and placed in the body to replace or repair tissue.