A threaded medical implant comprising a biocomposite, said biocomposite comprising a polymer and a plurality of reinforcement fibers, wherein a weight percentage of a mineral composition within the biocomposite medical implant is in the range of 30-60%, wherein an average diameter of said fibers is in a range of 1-100 microns, said medical implant being threaded with a plurality of threads; wherein said fibers comprise a plurality of helical fibers and a plurality of longitudinal fibers; wherein a weight to weight percent ratio of said helical to said longitudinal fibers is from 90:10 to 10:90.

There is a need for methods that can produce piezoelectric composites having suitable physical characteristics and also optimized electrical stimulatory proper-ties. The present application provides piezo-electric composites, including tissue-stimu-lating composites, as well as methods of making such composites, that meet these needs. In embodiments, methods of making a spinal implant are provided. The methods suitably comprise preparing a thermoset, thermoplastic or thermoset/thermoplastic, or copolymer polymerizable matrix, dispersing a plurality of piezoelectric particles in the polymerizable matrix to generate dispersion, shaping the dispersion, inducing an electric polarization in the piezoelectric particles in the shaped dispersion, wherein at least 40% of the piezoelectric particles form chains.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.

A 3D printed bone defect repair scaffold is provided and prepared by steps of: S1, dissolving a gelatin, sodium alginate and a 58S bioglass in water to obtain a solution, and mass-to-volume concentrations of components in the solution being that the gelatin is 16%, the sodium alginate is 6.5% and the 58S bioglass is 8.5%; S2, stirring the solution to obtain 3D printing slurry, and then conducting 3D printing, the 3D printing being performed with a nozzle with an opening diameter of 0.41 mm at a printing speed of 6 mm/s under a pressure of 0.38 Mpa and a temperature of 29° C.; S3, obtaining a semi-finished scaffold after the 3D printing, performing chemical crosslinking of the semi-finished scaffold with a calcium chloride solution for 8-15 min and then immersing in a glutaraldehyde solution for chemical crosslinking for 1.5-2.5 hours, and finally cleaning and lyophilizing.

Provided herein is a composite material for use in orthopaedic applications, and an orthopaedic implant made from such material, the composite material comprising a polymeric matrix material and further comprising a filler material comprising TiO.sub.2 and reduced graphene oxide. Also provided herein is a cranial prosthesis comprising a peripheral frame portion defining an aperture, and a removable insert portion for closing the aperture. Further provided is a cranial prosthesis comprising a core layer and a first skin layer, the first skin layer having a lower porosity than the core layer. The medical materials and devices disclosed herein may provide improved materials for use in orthopaedic applications, prostheses which offer improved access for revision surgery, and prostheses which offer improved bone integration and mechanical properties.

The disclosure relates to compositions and methods of treating, improving, and accelerating the healing of large segmental bone defects in a subject. The method comprises administering to a patient in need of treatment an effective amount of whole blood, sodium citrate, ecarin and BMP-2.

A scaffold is provided, the scaffold comprising: at least one inlet tube; at least one outlet tube; and a plurality of porous elongated microtubes, wherein each one of said porous elongated microtube has an inner diameter of 5-100 micrometers, wherein said plurality of elongated microtubes extend from said at least one inlet tube to said at least one outlet tube and is in fluid communication thereto, Further provided is a method for producing and using the scaffold, such a s for tissue engineering.

The invention concerns an implant material for filling bone defects, bone regeneration and bone tissue engineering, an implant comprising this material, a method for manufacturing such an implant material.

The implant material of the invention comprises a hybrid material doped with an osteoinductive nutrient N comprising: a bioactive glass M made from SiO.sub.2 and CaO, optionally containing P.sub.2O.sub.5 and/or optionally doped with strontium, and a biodegradable polymer P, this hybrid material being doped with an osteoinductive nutrient N.

The invention is applicable, in particular, in the medical field.

The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.