Compositions for treating a biofilm comprising viable microorganisms are provided. The compositions include a suspending medium, a bioactive glass comprising B.sub.2O.sub.3, and an effective amount of an antimicrobial compound selected from the group consisting of antimicrobial biguanide, quaternary ammonium compound, silver or copper deposited as a coating on the surface of the bioactive glass, and antimicrobial lipid component. Methods of treating a biofilm or a surface with the compositions are also provided.

Disclosed herein is a hydrogel wound dressing having a wound-contact side and a non-wound-contact side wherein the rate of moisture evaporation from said non-wound contact side is faster than the rate of moisture evaporation from said wound contact side, thereby causing said dressing to curl toward said non-wound contact side upon drying. Optionally, the hydrogel wound dressing can be comprised of two materials having different rates of moisture evaporation bonded together to form a bilayer structure.

The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

Compositions containing chlorhexidine gluconate solubilized in hydrophobic vehicles are described. Resin systems containing such chlorhexidine gluconate compositions, including adhesives and articles incorporating such resin systems, including medical articles such as drapes are also described.

The wound dressing described herein can be used as a contact layer dressing. The wound dressing can be positioned between a wound bed and a secondary dressing. The wound dressing can include a layered construction. Each of the layers can include a bioresorbable sponge enclosed within a collagen-based film. The wound dressing can include a plurality of fluid channels that enable fluid flow from the wound bed toward the environment-face side of the wound dressing.

Antimicrobial compositions and articles are disclosed, as well as method for preparing antimicrobial compositions. Also disclosed are method for using antimicrobial compositions and articles for preventing the formation or growth of biofilms, disrupting biofilms, reducing microorganism counts, and treating infections.

A valve including an antimicrobial agent can be used with needleless access connectors. The valve can have an insert that includes an antimicrobial coating thereon and/or the valve can have physical features, such as a series of tunnels or groves or a patterned surface, containing an antimicrobial formulation and/or the valve can be made of a material that includes an antimicrobial agent.

A needleless access connector having an access port and a sustained release antimicrobial coating only on a top surface of the access port is disclosed. The top surface of the access port can be defined by a top surface of a proximal end of a housing and a top surface of a head portion of a compressible valve disposed within an internal cavity of the housing. In certain embodiments of the present disclosure, the sustained release antimicrobial coating is on: (i) the top surface the proximal end of the housing, or (ii) the top surface of the head portion of the compressible valve, or (iii) the sustained release antimicrobial coating is only on both the top surface the proximal end of the housing and the top surface of the head portion of the compressible valve.

Coated medical devices include coated catheters. For example, a coated catheter can include a catheter tube of a tubular substrate and a coating thereover. The tubular substrate can be of a first polymeric material transparent to electromagnetic radiation in a range of visible light. The coating can be of a second polymeric material anchored to the tubular substrate by chain ends of the second polymeric material impregnated in the first polymeric material by way of a spent visible-light photoinitiator. Methods of coating can include methods of coating medical devices such as the coated catheter. For example, a method of coating can include irradiating a tubular substrate impregnated with a visible-light photoinitiator with the foregoing electromagnetic radiation while the tubular substrate is disposed in an aqueous solution of a monomer, thereby initiating a radical polymerization of the monomer and coating the tubular substrate with the coating of the second polymer material.