A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

Systems and methods for monitoring oxygenator performance in extracorporeal circuit systems or the like. More particularly, the disclosure relates to systems and methods including a controller programmed to determine oxygenator apparatus flow impedance as a function of an inlet pressure measurement, an outlet pressure measurement and a blood flow rate measurement. The systems and methods may include a communication device that receives signals from the controller to communicate information regarding oxygenator apparatus performance.

An oxygenator unit adapted for use in an extracorporeal blood treatment device. The oxygenator unit includes an oxygenator having a gas inlet and a supply line for conducting a gas provided at the gas inlet, the supply line being connectable to a source of a pressurized gas containing oxygen, wherein the oxygenator unit further includes a pressure relief valve provided in the supply line upstream of the oxygenator, the pressure relief valve adapted to release pressure exceeding a predetermined pressure value from the supply line, thereby preventing a critical overpressure in the oxygenator.

A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.

The invention relates to a degassing devive (25) for degassing blood, comprising a blood chamber (1, 1a, 1b) with a blood inlet (2) and a blood outlet (3), via which blood can be guided/is guided through the blood chamber (1, 1a, 1b), at least one underpressure chamber (11) with an underpressure attachment (8) via which the at least one underpressure chamber (11) is provided with an underpressure, at least one semipermeable membrane (4, 4a), which is arranged between the at least one underpressure chamber (11) and the blood chamber (1), wherein the blood chamber (1) comprises a first and a second sub-chamber (1a, 1b) which are arranged next to each other in a direction perpendicular to the direction of gravity, and a bridging region (9) which connects the two subchambers (1a, 1b) at their upper ends, wherein the blood inlet (2) is arranged in the lower region of the first subchamber (1a), and the blood outlet (3) is arranged in the lower region of the second subchamber (1b). The invention also relates to a system for extracorporeal treatment of blood.

Compositions, materials, devices and methods are disclosed for the use of decellularized avian lung scaffolds for potential xenotransplantation and other uses including use as novel lung assist or bridge-to-transplant devices and as potential alternatives to current ECMO devices and technologies. Decellularization of an avian lung and recellularization with human lung cells is described.

An oxygenator (10) for an extracorporeal ventilation system comprises a gas passage and a blood passage arranged to allow gas exchange of an oxygenation gas supply with blood via a gas-blood interface (34). The gas passage leads from a gas inlet zone (28) via the gas-blood interface (34) to a gas exhaust zone (40). The blood passage leads from a blood inlet (12) via the gas-blood interface (34) to a blood outlet (14). The oxygenator comprises a supply gas distribution arrangement (26, 28A, 28B). This allows the oxygenation gas supply to be modulated differently for different interface regions of the gas-blood interface. The oxygenator can be used to remove or reduce the formation of gaseous microemboli bubbles.

The present invention provides a highly-permeable dense hollow fiber membrane (HFM) for blood oxygenation. A membrane material plays a key role in an oxygenator, which determines the oxygenation efficiency, service life and safety of the oxygenator. The HFM according to the present invention features high permeability. When blood rich in carbon dioxide flows through the oxygenator, the carbon dioxide and oxygen in the blood can be rapidly exchanged, so that the blood can be rapidly updated, and the size of the oxygenator and the blood perfusion volume can be reduced. In addition, the membrane surface of the present invention is hydrophobic and dense, and blood does not directly contact with gas or permeate into a gas pipeline, thus avoiding the problems of protein leakage, permeability reduction and the like. The oxygenator prepared by using the HFM of the present invention can be repeatedly used for a long time.

An extracorporeal blood treatment device comprises a single housing defining an internal blood flow cavity. The housing accommodates an oxygenator, a heat exchanger and an additional mass transfer assembly, each having an array of fluid conduits. The arrays are co-located within the internal blood flow cavity such that blood flowing through the internal blood flow cavity flows substantially homogeneously around all the conduits. The arrays are arranged relative to one another within the internal blood flow cavity such that they together define a continuous blood flow path through the internal blood flow cavity along which blood can flow. The continuous blood flow path has a blood entry surface at one end and a blood exit surface at the opposite end. The overall blood flow direction from the blood entry surface along the blood flow path to the blood exit surface follows substantially a straight line.

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.