A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

A method of treating, reducing, or alleviating a medical condition in a patient is disclosed herein. The method includes administering to a patient in need thereof a biocompatible drug comprising one or more antiviral medications together with one or more cell pathway inhibitors dissolved in a non-toxic semifluorinated alkane, the patient having one or more respiratory tract inflammatory diseases, the one or more cell pathway inhibitors blocking an inflammatory response of inflamed tissue without inhibiting an immune response of the patient, and the semifluorinated alkane evaporating quickly upon administration to the patient so as to leave the biocompatible drug at a desired treatment location. The administration of the biocompatible drug to the patient treats the one or more respiratory tract inflammatory diseases, reduces the symptoms associated with the one or more respiratory tract inflammatory diseases, and/or alleviates one or more respiratory tract inflammatory diseases.

Device (100, 201) for the adjustment of temperature, especially for the extracorporeal adjustment of the temperature of patients, with a transfer of heat between a fluid and a transfer medium, including a temperature-adjustment body (203) having a primary side which provides a guide for the fluid and having an application side which provides a surface (219) for contacting the temperature-adjustment body (203) with the transfer medium; a cover (221) which is attached to the temperature-adjustment body (203) and which forms a cavity with the temperature-adjustment body (203) on the application side, through which cavity the transfer medium can flow; the cover (221) being attached to the temperature-adjustment body (203) in a detachable manner; and flow-guiding structures (217) for guiding the transfer medium being arranged on the temperature-adjustment body (203) and/or on the cover (221).

A system for the extracorporeal elimination of carbon monoxide, includes at least one pump and a gas exchange chamber, wherein the at least one pump can be connected to the blood circulatory system of a person by way of a first tube section connectable to a cannula and is connected to a gas exchange chamber via a second tube section, wherein the system is configured to transfer blood, via the first tube section, from the blood circulatory system of the person by way of at least one pump into the gas exchange chamber, and to return the blood from the gas exchange chamber to the blood circulatory system of the person via the same first tube section.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

A method and system for infusing medical liquid with gasses, the system comprising a gas source, a vacuum pump, a temperature-controlled container including a fluid reservoir coupled to the gas source and the vacuum pump, a heating and cooling system, and a sonicator, and a controller configured to de-gas a liquid in the fluid reservoir by activating the vacuum pump, re-gas the liquid in the fluid reservoir by releasing gas from the gas source to the fluid reservoir via a first fluid line, and deliver the re-gassed liquid from the fluid reservoir to a catheter via a second fluid line.

A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.

An exchanger for medical use comprises: a box-like body having a base, an upper end, a peripheral wall that delimits a heat exchange chamber; the body having: a first aperture from which a fluid to be thermo-regulated enters and a first exit of the thermo-regulated fluid; a second delivery aperture of a thermo-regulator fluid and a second exit of the thermo-regulated fluid; a heat exchange element that exchanges heat by lapping, housed in the exchange chamber and held between two holding elements, dividing the exchange chamber into a zone where the thermo-regulator fluid flows and a zone where the fluid to be thermo-regulated flows, which are fluid-dynamically separated from each other; a collection compartment to collect the air separated from the fluid to be thermo-regulated, obtained in the opposite end, connected to the thermo-regulation chamber and equipped with an aperture toward the outside; the box-like body has a second housing chamber for a pumping group, connected with the heat exchange chamber.

Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

A system (20) including a heater/cooler module (22) to heat/cool a first fluid in a primary circuit (28), a heat transfer fluid circuit (24) to provide a second fluid to a target device (38) to heat/cool the target device (38), and a heat exchanger (26) including at least part of the primary circuit (28) and at least part of a secondary circuit (36) through which the second fluid flows to facilitate heat transfer between the first fluid and the second fluid. The primary circuit (28) and the secondary circuit (36) are separate circuits and the first fluid and the second fluid remain separated in the system. Also, the system is modular, such that the elements can be stacked to increase heating/cooling capability and/or to increase the number of heating/cooling channels, and the system is compatible with portable applications, such as ambulance, aircraft, and helicopter applications, and with battery operation and/or the use of uninterruptible power supplies.