Nanoparticles are suspended in a fluid medium which is activated using an ultrasonic transducer in contact with the fluid medium. The fluid may be injected into a body cavity and ultrasonically activated to induce a cavitation effect. The body cavity may contain a natural or artificial hard surface, inflamed or with a biofilm harnessing bacteria, such as a bone, joint or implant, as well as the surrounding tissue. In an embodiment, a treatment device may be used before, during or after a procedure such as a minimally invasive or open surgery to disinfect the body cavity via irrigation with liquid containing suspended nanoparticles and ultrasonically activated. The irrigation device may supply the cavity with the liquid and include therein an ultrasonic transducer. The cleaning and disinfecting process may be performed as treatment of infection in absence of another surgical procedure.

Fluid management systems are disclosed that include software-controlled, electro-mechanical devices used in combination with single-use or multi-use tubing sets. Functions of the fluid management systems can include fluid pressurization, fluid warming, fluid deficit monitoring (including flow-based and weight-based), suction, fluid collection, and fluid evacuation (including indirect-to-drain and direct-to-drain options). The systems can be configured based on the surgical environment (e.g., operating room or physician office) as well as other user needs and/or preferences.

A phacoemulsification system includes a pump and a processor. The pump includes: (i) a first chamber having a first volume and configured to flow a first fluid at a first flow rate, between a first reservoir and an eye of a patient, and (ii) a second chamber having a second volume and configured to flow a second fluid at a second flow rate, between a second reservoir and the eye. The processor is configured to control the pump to: (i) set a first flow rate of the first fluid in the first volume, so as to obtain a predefined intra-ocular pressure (IOP) in the eye, (ii) based on the first and second volumes and on the first flow rate, calculate a second flow rate of the second fluid that maintains the predefined IOP constant, and (iii) set the calculated second flow rate to the second fluid.

A controller for a body cavity irrigation system, where the system features a reservoir containing an irrigation liquid and a catheter, includes a housing with a dial attached to the housing and movable between positions corresponding to stages of a body cavity irrigation procedure. The controller is in communication with an electromechanical pump and at least one electromechanical valve that are in fluid communication with the reservoir and the catheter so that the electromechanical pump and at least one electromechanical valve are configured to perform a stage of the body cavity irrigation procedure corresponding to the selected dial position.

The invention relates to an ophthalmic pressure control system, comprising: a pressure regulator having an input port and an output port, and an infusion line having a proximal end and a distal end, the proximal end being connected to the output port of the pressure regulator, and the distal end being detachably connected to an ophthalmic irrigation module. Further, the system includes a control unit driving the pressure regulator for controlling an infusion fluid pressure at a distal end of the ophthalmic irrigation module. The control unit is arranged for performing a fluid calibration process including a step of determining a fluid impedance of the ophthalmic irrigation module. The infusion line is associated with a kit of parts including a first and a second ophthalmic irrigation device, or the ophthalmic irrigation module is an ophthalmic irrigation device for surgical use.

A method for operating a fluid management system includes automatically detecting an unstable condition in the system, which may include detecting a large change in the supply fluid amount (indicative of a bag change), detecting a large change in the waste fluid amount (indicative of a bag change), or detecting a large difference between the amount of fluid dispensed as measured by the weight data and the amount of fluid dispensed as measured by the flow data (indicative of a blockage in the supply tubing). The method further includes adjusting the operating mode of the system during the unstable condition, which may include switching to using flow data rather than weight data to track the fluid deficit during a supply bag exchange, halting operation of an outflow pump during a waste container exchange, and/or halting operation of the system during a blockage in the supply tubing.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

A suction/irrigation medical device valve system comprises a first valve plunger configured for insertion into a first valve plunger channel. The first valve plunger has a first latch member disposed at a distal end with a first sealing member and a first valve opening disposed proximally from the first latch member. The system also comprises a second valve plunger configured for insertion into a second valve plunger channel. The second valve plunger includes a second valve opening that is longer than the first valve opening. The system also comprises a valve body having the first and second valve plunger channels. The first and second valve plunger channels are configured to receive the first and second valve plungers, respectively.

Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.