The invention regards an applicator tube for delivering a paste from a syringe, comprising: a delivery tube comprising a distal end for delivering the paste, and a valve system attached to a proximal end of the delivery tube and configured for attachment to the syringe, the valve system having a first configuration allowing aspiration of gas from the surroundings, and a second configuration allowing expression of aspirated gas into the delivery tube, such that the applicator tube is configured for transporting a volume of aspirated gas into and through the delivery tube when an attached syringe is aspirated and expressed.

A needleless pain-free injection device according to the present disclosure includes a valve body, a valve member provided in an internal space of the valve body and airtightly sliding along the valve body, a liquefied gas container communicating with the internal space of the valve body and detachably coupled, at one end thereof, to the valve body, an operating knob provided on the exposed end of the valve member, a cylinder body coupled to one side of the valve body and having an internal space, a piston member provided such that one end thereof slides in the internal space of the cylinder body and having a piston rod, an injection unit provided with an injection piston rod coupled to the piston rod, and a gas passage forming means for selectively establishing and blocking the communication of the valve body and the cylinder body with outside air.

A therapeutic agent delivery system includes a therapeutic agent delivery assembly carried by a housing. The therapeutic agent delivery assembly includes a chamber including a first passageway, a therapeutic agent carried in the first passageway, and a needle in communication with the first passageway. The therapeutic agent delivery assembly is translatable relative to the housing from a stowed configuration to a deployed configuration. The therapeutic agent delivery assembly is also translatable relative to the housing from the deployed configuration to a retracted configuration. The system further includes a user input that is actuatable to translate the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. The system further includes a retraction mechanism that is actuatable to translate the therapeutic agent delivery assembly from the deployed configuration to the retracted configuration.

Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

A pen-like syringe system includes: a syringe holder for receiving a syringe having a syringe barrel and a plunger guided for movement in the barrel; and a drive housing connected to the syringe holder. To provide an ergonomic syringe system which allows advantageous operation of the system and guarantees safe and focused injection or drawing of a substance the drive housing includes an electric delivery device operated by an integrated power supply for applying pneumatic pressure or negative pressure to the plunger, with the delivery device connected via a drive channel to the plunger and actuatable by a button arranged on the syringe system; and the pen-like syringe system has a vent duct with a first end, which is connected to the drive channel, and a second end, which is connected to the surroundings via an opening, with the opening closable by pressing the button.

A medical fluid injection device, a medical fluid transfer device and a method of administering and transferring a medical fluid are disclosed. The device and method may include a compressed gas canister in fluid communication with an expandable elastic bladder positioned within a vial of drug to provide a means to deliver drug through an injection cannula that is movable between a plurality of positions or through a transfer conduit.

A needleless syringe having a multi-nozzle and a manufacturing method therefor are proposed. The needleless syringe injects a drug solution through an injection nozzle by expanding a pressure-generating liquid by means of energy generated from a pressure-generating unit, wherein precise branch channels are stably formed so as to inject drugs into a plurality of parts by using multiple injection nozzles. Further, the present disclosure has advantages in that: one energy-generating unit is used and thus nozzles can be densely arranged with a small distance therebetween; when several injections into an affected part are needed, the treatment time can be shortened using multiple injection nozzles; and an inner chamber is inserted into and coupled to or is insert injection-molded in an outer chamber so that more stable and precise branch channels can be formed, and thus multiple drugs can be stably injected into an affected part through multiple injection nozzles.

A crack resistant member including a member body, a first region that is a hollow space provided in the member body to open to a surface of the member body and is configured to dispose a driving part that outputs a pressing force in an extension direction of the space, and a coupling portion that is configured to mechanically couple to the driving part and is formed on an inner wall surface of the first region, in which at least the coupling portion is formed from a resin material having a flexural modulus of 2600 MPa or greater as measured in accordance with ISO 178.

A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.

A remote delivery device is provided which has media portholes in a sidewall, a tail piece attached to a rear end and a cannula attached to a front end. The body contains a plunger assembly which defines an injectable liquid chamber and a marking media chamber. The plunger assembly includes a front barbell plunger, rear barbell plunger and a plunger shaft with an O-Ring seated between the front and rear of said plunger shaft. The body also contains a single internal charge positioned behind the plunger assembly. When the charge is activated, the plunger assembly is thrust forwardly and dispenses an injectable liquid from the injectable liquid chamber through the cannula. Simultaneously, the plunger assembly also dispenses a marking media from the marking media chamber through marking media portholes. The provision of a single internal charge allows for a reduction in the length and weight of the device. The single internal charge provides evidence of successful injection of the injectable liquid when the media is displaced from the marking media chamber.