A deformable cartridge for an injection device of an injectable solution has a cartridge body having a first containment chamber of a first component of the injectable solution, having a first compression-deformable wall, a second containment chamber of a second component of the injectable solution, having a second compression-deformable wall to allow the second component to be transferred from the second containment chamber to the first containment chamber, a separation device interposed between the first and the second containment chambers and having a device body. A fluidic communication duct is defined in the device body. The deformable cartridge assumes a first operating configuration in which the fluidic communication duct is not crossable by the second component and a second operating configuration in which the fluidic communication duct is crossable by the second component. A needle holder component is fixed to the cartridge body and fluidly connected to the first containment chamber which is interposed between the needle holder component and the separation device.

A delivery assembly includes a console including a vial containment region and a vial engagement mechanism extending from the console within the vial containment region. The engagement mechanism is configured to engage a vial assembly. The delivery assembly further includes a sled assembly removably coupled to the console at the vial containment region and a safety shield removably coupled to the console over the vial containment region such that the vial engagement mechanism and the sled assembly are encapsulated within the safety shield when the safety shield is coupled thereto. The sled assembly, the vial assembly, and the safety shield are configured to inhibit radioactive emissions from within the vial containment region.

The present invention provides a solution for zero-point adjustment of drug delivery devices, including twin chamber drug delivery devices with a single dose engine.

A vial assembly includes a vial and a needle with at least one port. The vial includes a particulate material, a septum, a neck region including a first width, and a particulate region including a second width greater than the first width. The vial assembly is configured to move to a locked position. The needle may be configured to puncture the septum with the at least one port configured to be in the neck region when in the locked position. The at least one port may be configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of a vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second direction opposite the first direction.

A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.

A delivery assembly includes a console including a vial containment region and a vial engagement mechanism extending from the console within the vial containment region. The engagement mechanism is configured to engage a vial assembly including a particulate material. The delivery assembly further includes a multi-port needle with a top distal port and bottom proximal port(s), the needle configured to puncture a septum of the vial assembly when the vial assembly is in the locked position, in which the top distal port is at a distance above the particulate material in the vial assembly. The ports are configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of the vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second opposite direction.

Described is a mixing syringe for receiving a removable carpule partitioned to form two reservoirs independently containing anesthetic solution and buffering solution and having a mixing chamber for mixing the solutions during administration, and methods of using the mixing syringe.

An injection system includes an injection system body defining a proximal opening at a proximal end thereof and a distal needle interface at a distal end thereof. The system also includes proximal and distal stopper members disposed in the injection system body, forming a proximal drug chamber between the proximal and distal stopper members and a distal drug chamber between the distal stopper member and the distal end of the injection system body. The system further includes a plunger member configured to be manually manipulated to insert the proximal stopper member relative to the injection system body. Moreover, the system includes a valve forming an openable barrier between the distal needle interface and at least a portion of the distal drug chamber. The valve is configured to allow flow from the portion of the distal drug chamber to the distal needle interface with increased pressure in the distal drug chamber.

A device (200) for mixing first and second substances. The device comprises a first container (100) for storage of the first substance and a second container (150) received in the first container (100) and for storage of the second substance. An outlet (112) is disposed at the distal end of the first container (100). Valve means (180) are provided for closing a distal end of the second container (150) and a proximal end of the first container (100). A stopper means (166) closes a proximal end of the second chamber (152) and is movable with respect to the second container (150). An operating mechanism drives relative movement between the first and second containers for causing displacement of the second substance into the first chamber (102) through the valve means (180) when the outlet (112) is closed, for mixing the first and second substances in a mixing stroke of the device.

The present disclosure relates to a syringe including a container, for containing a primary fluid, and at least one secondary fluid chamber configured to contain a secondary fluid. The container comprises a proximal end and a distal end and having a distal end opening at the distal end. The syringe further comprises a stopper, movably arranged within the container; and a plunger engageable with the stopper and configured to apply a force to the stopper to move the stopper within the container towards the distal end of the container, to expel primary fluid from the container through the distal end opening. The plunger is further configured to expel secondary fluid from the at least one secondary fluid chamber towards the distal end opening, to expel at least a portion of a residual volume of primary fluid through the distal end opening. A plunger system and assembly for a syringe and methods of expelling fluid from a syringe are also disclosed.