A device and a method for adjustable quantitative injection of high-pressure gas are provided, wherein the gas may have a pressure of 5 MPa or more than 5 MPa. The gas may be directly communicated with a gas tank in the mechanism or an external gas source, flows through corresponding valves, and is charged into a predetermined or adjustable reservoir. Alternatively, the valve may be time-controllable, and does not need the reservoir. The gas is ejected through a nozzle selected based on depth or range of injection, wherein a one-way valve is disposed between the nozzle and the body to prevent contamination due to backflow. The manipulator can exert an appropriate force onto a target portion of a human for gas injection, and when the injection is done, a biasing member can automatically return the mechanism to its original state, ready for the next injection.

The present disclosure relates to a medicament delivery device comprising a medicament receiving element, at least one fluid chamber having a fluid outlet configured to direct fluid vapour towards the medicament receiving element, a heating element for heating the fluid in the at least one fluid chamber. The device is configured such that, in use, the heating element heats the fluid in the at least one fluid chamber to at least partially evaporate the fluid so that the vapor pressure in the at least one fluid chamber increases until the fluid is expelled out of the at least one fluid chamber through the fluid outlet towards the medicament receiving element and entrains the medicament towards the patient's skin.

A needleless syringe comprises an enclosing unit for an injection objective substance, a pressurizing unit for the injection objective substance, a discharge unit having a flow passage for allowing the injection objective substance to flow therethrough so that the injection objective substance is discharged from an open end of the flow passage to an injection target area, the open end being formed so that an area thereof is smaller than a flow passage area of the enclosing unit, and a minute pore unit including a minute pore having a flow passage area smaller than the area of the open end of the discharge unit and which is arranged on an outer side of the open end so that the injection objective substance discharged from the open end passes through the minute pore and arrives at a side of the injection target area.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Disclosed is drug delivery system for effectively administering a drug into a human or animal body tissue. The microjet drug delivery system includes (a) a microjet injector including: a pressure chamber partially sealed by an elastic membrane and containing a pressure-inducing liquid fluid-tightly filled therein; and a drug chamber adjacent to the pressure chamber, wherein the elastic membrane is disposed between the pressure and drug chambers, wherein the drug solution is contained in the drug chamber, wherein the drug chamber has a micro-nozzle partially defined in a wall thereof for ejecting the drug solution out of the drug chamber; (b) a laser generator for generating a laser beam and emitting the laser beam out of the laser generator, wherein the laser generator is configured by irradiating the laser beam into the pressure-inducing liquid in the microjet injector, thereby generating a bubble in the pressure-inducing liquid; and (c) a fractional laser filter module configured for splitting the laser beam incident from the laser generator into a plurality of fractional laser beams, each beam has a reduced diameter, and for irradiating the fractional laser beams. According to the microjet drug delivery system, the pre-ablating of the skin with the fractional laser beams to partially remove the stratum corneum may enable the drug microjet based injection to allow the drug to be effectively invaded into a skin tissue at the portion where the stratum corneum is partially removed and relatively softened.

Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.

Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.

A needleless injection device includes a body forming a receptacle extending axially from an upper radial seat along an injection axis, a gas generator, a tubular reservoir containing an active ingredient and extending axially in the receptacle from an upper end to a lower end, and a nozzle for injecting the active ingredient. The nozzle is arranged at the lower end of the reservoir and has an outer thread to be screwed onto a complementary thread formed by the body. The external thread of the nozzle has an overall triangular cross-section and is delimited by an upper face, which has a first angle with respect to a radial axis perpendicular to the injection axis, and a lower face, which has a second angle with respect to the radial axis. The first angle is greater than the second angle.

An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.

An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.