A video feed of one or more pupils of a patient can be received and processed to determine a raw measure of pupil size of the one or more pupils over time. Based on this raw measure, at least one of a) a depth of anesthesia for the patient, b) an index of cognitive activity for the patient, and c) a degree of perfusion of an anesthetic being administered to the patient to one or both hemispheres of a brain of the patient can be determined such that one or more actions can be caused to be performed. Related systems, methods, and article of manufacture are described.

A diffusing applicator is provided and generally includes a head unit, and extension shaft, and a dispensing device. The head unit includes a fluid receiving space and a plurality of dispensing passageways in communication the fluid receiving space. The extension shaft is securely connected to the head unit. The dispensing device is for holding a fluid and is connected to the extension shaft. The dispensing device is in communication with the plurality of dispensing passageways and urges fluid through extension shaft and through the dispensing passageways.

A medicament delivery device includes a main injection needle for injecting a medicament into the body of a patient. The medicament delivery device includes a pain reduction device for releasing a pain reduction agent into the body of the patient prior the medicament injection. The pain reduction device includes an array of microneedles.

An apparatus is provided for facilitating intranasal treatment of a patient's sphenopalatine/pterygopalatine recess. The apparatus includes an intranasal spray delivery device configured to contain a spray composition, atomize the spray composition, and deliver the atomized spray composition to the sphenopalatine/pterygopalatine recess of the patient. In certain examples, the spray composition includes about 2.5% lidocaine and about 0.10% maltoside. A method is also provided and includes providing, in a solution, about 2.5% lidocaine, providing, in the solution, about 0.10% maltoside, and placing the solution in an intranasal spray delivery device configured to contain the solution and deliver the solution to the sphenopalatine/pterygopalatine recess of the patient.

A device to check the quality and dosage of anesthetic dispensing device that is used for the application of anesthetic fluids using a spray nozzle is provided. This device can be adapted for use in the oral cavity and upper tracheal area of a medical patient prior to intubation of such patient. The present device comprises of a camera system, a stroboscopic lighting system, and an image analysis software.

A method for making a container for retaining anesthetic agent. The method includes creating two or more parts each having a mating surface, where the container is formed when the mating surfaces of the two or more parts are coupled together, and where a first part of the two or more parts is formed of a material having pores defined within the mating surface thereof. The method further includes processing the mating surface of the first part via friction stir welding to reduce the pores defined therein. The method further includes coupling the two or more parts together such that the mating surfaces contact to create the container configured to retain the anesthetic agent therein.

The present invention is directed to a method an apparatus for buffering an anesthetic solution prior to an injection. The inventive apparatus employs a modified carpule which hold two solutions in fluid isolation. The buffering solution is separated from the anesthetic solution within the same carpule by way of a fluid impervious thin film. The thin film has a weakened central area which can be easily pierced by a harpoon affixed to one side of a plunger. As the plunger is advanced forward, the harpoon breaks through the thin film and causes mixing of the two solutions.

A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Module for housing electronic and electromechanical medical equipment including a portable digital camera and processing circuitry with machine vision and machine learning software for automatically documenting healthcare events and healthcare equipment operations in the electronic health record.

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiO.sub.x composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O.sub.3—Si—C covalent bonding, as a proportion of the O.sub.3—Si—C covalent bonding plus SiO.sub.4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO.sub.4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.