A medical elongated body including a catheter main body. The catheter main body has a tubular body and a lumen. The tubular body includes a guide wire lumen into which a guide wire is insertable. The tubular body also a distal member positioned at the distal portion of the tubular body. The distal member has a lumen that communicates with the guide wire lumen. The inner diameter of the distal member decreases between the proximal end and a distal end opening of the distal member. The medical elongated body also includes a visible marker that extends circumferentially on the outer surface of the distal member to indicate a position of the distal member in the axial direction corresponding to a predetermined inner diameter of the distal member. The visible marker is visible before the medical elongated body is inserted into a living body.

Medical devices which are compatible with a camera for ventilating, intubating, and extubating a patient under continuous visualization. Methods for ventilating and intubating a patient with the medical devices.

An expandable dilation member may include a proximally-tapered portion to dilate a stricture. The dilation member may be distally advanced in an unexpanded state over a wire guide through the stricture. The dilation member may then be configured in an expanded state, where the dilation member has a longitudinal profile that includes the proximally-tapered portion. A handle assembly proximally pulls the dilation member in the expanded state. In response, the proximally-tapered portion engages with and biases the stricture. When biasing the stricture, the proximally-tapered portion exerts a plurality of different types of forces, including a shearing force, a radial force, and in some procedures, a torsional force. In some embodiments, the proximally-tapered portion has a continuous taper from a smallest diameter to a largest diameter. In other embodiments, the proximally-tapered portion has at least one constant-diameter portion longitudinally disposed in between the smallest diameter and the largest diameter.

Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.

A system is disclosed for performing an endoscopic surgical procedure in a surgical cavity, which includes a multi-modal gas delivery device including a primary gas circulation pump, a secondary gas circulation pump and an insufflation subunit, and an interface plate adapted and configured to engage with the multi-modal gas delivery device and including a connector and a filter seat corresponding to five different lumens, each of which provides a different functionality.

A ventilation system provides patient-triggered support ventilation to a spontaneously breathing patient during ongoing high frequency ventilation (HFV), and has a pneumatic unit operated by a control computer for delivery of breathing gas in response to an effort to breathe by the patient, and an oscillator for superimposing high frequency oscillation onto the breathing gas. The system further includes a bioelectric sensor that measures a bioelectric signal indicative of the patient's efforts to breathe, and the control computer controls the delivery of breathing gas in response to the patient's effort to breathe, based on this bioelectric signal. The ventilation system is hence designed for neurally triggered support ventilation during ongoing HFV, which makes the trigger mechanism of the ventilation system more precise and robust compared to known trigger mechanisms of HFV ventilation systems.

A method of preventing contraction and peristaltic wave action of an esophagus in which a GARD is placed, preventing displacement of the GARD towards or into a stomach, the method comprising injecting botulinum toxin very precisely in the muscular layer of the esophageal wall at the level where the GARD is or will be placed. A system comprising a catheter having one or two expandable balloon(s) which carries guide needle catheters that can pierce the esophageal wall and reach precisely the muscular layer of the wall of the esophagus, the needles used to inject the toxin at precisely the exact location in the esophageal wall in relationship with the GARD device to block esophageal peristalsis locally.

A drug delivery system is described. The system has a first fluid delivery reservoir and a second fluid delivery reservoir. The first reservoir is separately controllable from the second reservoir. The first reservoir and second reservoir are attached to a manifold having a first solution channel in fluid communication with the first reservoir and a second solution channel in fluid communication with the second reservoir. The manifold is connected to a catheter having a first lumen in fluid communication with the first solution channel and a second lumen in fluid communication with the second solution channel. The catheter has a first balloon in fluid communication with the first lumen and a second balloon in fluid communication with the second lumen. The first balloon is located within the second balloon. The first balloon is not in fluid communication with the second balloon and the second balloon is perforated. A method for using the system and a kit containing the system are also described.

A drug delivery system is described. The system has a first fluid delivery reservoir and a second fluid delivery reservoir. The first reservoir is separately controllable from the second reservoir. The first reservoir and second reservoir are attached to a manifold having a first solution channel in fluid communication with the first reservoir and a second solution channel in fluid communication with the second reservoir. The manifold is connected to a catheter having a first lumen in fluid communication with the first solution channel and a second lumen in fluid communication with the second solution channel. The catheter has a first balloon in fluid communication with the first lumen and a second balloon in fluid communication with the second lumen. The first balloon is located within the second balloon. The first balloon is not in fluid communication with the second balloon and the second balloon is perforated. A method for using the system and a kit containing the system are also described.

A treatment tool for an endoscope of the present invention includes a sheath, a balloon provided at the sheath and configured to be expandable to an inflated state from a reduced diameter state by injecting a fluid, a shaft member inserted through an inside of the balloon and configured to extend along a longitudinal axis of the sheath from a distal end of the balloon to a proximal end thereof, and an adhering portion provided on a side of an inner surface of a central portion of the balloon in a direction of the longitudinal axis, formed of an adhering material applied or adhered to the shaft member and configured to hold the central portion in a state in which the central portion is reduced in diameter.