An indwelling device for treating flora includes probiotics, a carrier carrying the probiotics and including a first region arranged in an appendico and a second region arranged in an intestinal cecum, in which the probiotics are carried in the first region and the second region contains an antibacterial agent.

Devices, systems for localized delivery of a chemotherapy, hormonal therapy or targeted drug/biologic therapy to a target tissue area of an internal body organ of a patient. A catheter 10 forms a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin. The drug may saturate the target tissue area and pass therethrough into the lymphatic system or interstitial space, which may serve as a reservoir of the drug for continued therapeutic treatment after withdrawal of the catheter. The chamber is evacuated at the end of the treatment session.

The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

A drug delivery system is provided that has an adjustable dose mechanism allowing setting and locking the dose then administration of the set dose. A method for administering a medicament using the drug delivery system is also provided.

Apparatuses, devices, and methods for performing endoscopic tissue resectioning in the gastrointestinal tract are disclosed. In some embodiments, a tissue resectioning device may include first and second scaffolds each arranged in a tubular configuration. The tissue resectioning device may further include a hook tool engageable with the first scaffold and/or the second scaffold to bias the scaffolds to engage a target section of tissue between the first scaffold and the second scaffold. The hook tool may also engage the section of tissue to pull the section of tissue into the path of a cutting edge of each of the first and second scaffolds. In some embodiments, the tissue resectioning device is provided over a scope, which extends within a lumen of an overtube.

The present invention is a system and method for water cycling colonoscopy that includes a colonoscope with a water ejection system and a camera, and a rectal overtube that receives the colonoscope therein. The overtube is placed in the anus and has a vacuum port outside the anus that attaches to a vacuum source. The overtube vacuum port vacuums water emitted by the colonoscope while the colonoscope is moving through the colonic lumen to control the amount of fluid in the colonic lumen. The overtube may be fitted with structures to improve the fit and attachment to the anus, including an inflatable cuff and a flexible skirt.

The present disclosure provides with a device (100) for temporary residence at an ileocecal valve of a subject, the device carrying a load of an active pharmaceutical ingredient (API) and having an expanded configuration. When the device is positioned at the ileocecal valve and in the expanded configuration, the device is configured to be retained at the ileocecal valve of the subject, and for releasing at least partially the active pharmaceutical ingredient while allowing chyme flow. The device is further configured to transfer from the expanded configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. This enables dispensing locally therapeutic substances at an ileocecal valve (ICV) region of a human body.

A bowel irrigation system comprising a container adapted for containing a liquid, a catheter comprising an inflated balloon, a tubing connecting the container and the catheter, a pump, a control unit for controlling a flow of fluid in the system, and a pressure sensor is disclosed. The system comprises means for deflating the balloon, as a response to an assessment of a first pressure inside the balloon being greater than a first threshold value, by reducing the amount of liquid inside the balloon by a first amount of liquid. In addition, a method for deflating an inflatable balloon, as a response to an assessment of a first pressure inside the balloon being greater than a first threshold value, by reducing the amount of liquid inside the balloon by a first amount of liquid is disclosed.

The invention relates to a device for transanally introducing an infusion into the rectum or colon of a patient, said device comprising a catheter with a catheter shaft wherein, to ensure the most practicable catheter insertion possible, the catheter shaft is equipped in the proximal, preanal region with gripping depressions to accommodate the fingers gripping the catheter during insertion.