Systems and methods for reducing pathogens near an implant are discussed. In some cases, the methods include reducing contaminants in a portion of a patient that has an implant and that is disposed interior to a closed surface of skin of the patient. The method can further include placing a conduit in the closed surface of skin and flowing an antimicrobial fluid into that portion of the patient to contact the antimicrobial fluid with a surface of the implant and tissue adjacent to the implant. In some cases, the antimicrobial fluid is then removed from the portion of the patient having the implant. As part of this method, biofilm near the implant can be mechanically, ultrasonically, electrically, chemically, enzymatically, or otherwise disrupted. Other implementations are described.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

A system comprising a handpiece and drive system configured to removably couple to a proximal end of a housing. A scalpet assembly is configured to removeably couple to the housing, and includes a scalpet array comprising at least one scalpet configured for rotation. The scalpet array is configured to harvest dermal plugs via fractional resection. A collection chamber is configured to collect the dermal plugs, and to house formation of an injectable filler by mincing the dermal plugs, and mixing the dermal plugs with a carrier. The injectable filler is configured for bulk fill. The collection chamber includes a loading port, and a cannular syringe is configured to mate with the loading port to receive the injectable filler, and to deliver the injectable filler for the bulk fill.

A waste management appliance includes a tubular body having a proximal end and a distal end, a cowl fastened to the tubular body at a first circumferential location in a vicinity of the proximal end, a balloon provided within the cowl, and an inflation lumen opening to an interior of the balloon and extending toward the distal end of the tubular body. The cowl extends outside of the tubular body to a second circumferential location spaced from the first circumferential location and is fastened to the tubular body at the second circumferential location. The balloon is inflatable to a desired extent within the cowl by injecting a predetermined amount of fluid into the balloon via the inflation lumen; the cowl restrains inflation of the balloon beyond the desired extent in the event of an injection of more than the predetermined amount of fluid into the balloon.

A cartridge for delivery of a material therefrom which has a corrugated portion to allow for bending/extending to be applied to the device from which a material to be deposited can be dispensed. The bendability and extendibility allow for greater efficiency in use and application of the material into cavities, pockets, and/or crevices where one needs to deposit the material.

Pressure conditioning systems for supplying insufflation gas to an open-ended body conduit such as a rectal cavity during a transanal minimally invasive surgery (TAMIS) procedure can reduce billowing of walls of the body conduit. A pressure conditioning system can include a pressure storage component, an accumulator, and a flow restrictor. The pressure storage component can include a variable volume reservoir that is biased to a relatively low volume state. The flow restrictor can include insufflation tubing with a restrictor plate having a relatively low diameter orifice. The pressure storage component, accumulator, and flow restrictor can be fluidly connected in various orders in series or as side branches from a gas flow conduit. Despite a pulsed or otherwise discontinuous insufflation gas flow and leakage and absorption from the body conduit, the pressure conditioning system can maintain a constant pressure within the body conduit.

The device (10, 36, 38, 42, 68) applies a negative pressure to an endoluminal surface in the body of a patient to facilitate healing of a wound in the endoluminal surface. The device comprises a flexible porous element (14) with a peripheral outer face (32) for contact with the wound, the outer face being defined between opposite proximal and distal ends of the porous element. A suction tube (30) for being connected to a suction source externally of the patient's body is provided in fluid communication with the porous element to apply a negative pressure to the wound via the outer face (32) of the porous element (14) upon operation of the suction source. The porous element (14) has at least one through passageway (16) extending from its proximal end to its distal end for passage of bodily substances of the patient through the porous element. The device can also include a drainage tube (22) for collection and drainage of the bodily substances from the patient, wherein the drainage tube is received in the through passageway of the porous element. The device is particularly suitable for assisted healing of anastomotic wounds but its use is not limited thereto.

The present disclosure provides devices for preventing or absorbing fluid (e.g., sweat) and/or odors from the intergluteal cleft of a subject. In some embodiments, the present disclosure provides devices for treating or preventing hemorrhoids and methods of using same.

Certain embodiments of a medicinal applicator can comprise a base, a medicinal cream receiving port in the base, and a shaft extending along a conceptual shaft axis from the base and terminating at an applicator tip. There is at least one exit aperture located along a portion of the shaft. An unobstructed pathway is in communication with the receiving port and the exit aperture. A stop plate that extends essentially radially from the base delineating the base from the shaft. The shaft possesses a shaft outer shape defined by a shaped leading and trailing edge defining a narrow diameter proximal zone that extends along the shaft from the stop plate to a gradually increasing diameter transition zone that extends to a large diameter paddle zone, which terminates into a shaft distal end.

A tube coupling system serves for providing annular flow through a flexible annular double lumen tube between fluid reservoir(s) and flexible connection pieces of an annular double lumen device. The tube coupling system has a first coupling component and a second coupling component and an end fitting system. The first coupling component that has a female coupling part and a male coupling part adapted for coupling to a proximal end of the flexible annular double lumen tube. The second coupling component has a second interior pipe that axially extends inside a second exterior pipe, a first end fitting adapted for coupling to at least the female coupling part of the first coupling component, and a second end fitting adapted for coupling to any of the flexible annular double lumen tube or the flexible connection pieces of an annular double lumen device.