A leafless biostimulator, such as a leadless pacemaker, includes a housing sized and configured to be implanted within a heart of a patient and includes both primary and secondary fixation features. The primary fixation feature is adapted to rotate to fix the leadless biostimulator to a wall of the heart during initial implantation. Once the leadless biostimulator is implanted, the secondary fixation feature is adapted to resist counter-rotation of the leadless biostimulator. The primary fixation feature may include a fixation helix configured to affix the housing to the heart by rotating in a screwing direction. The secondary fixation feature may include an apex to engage the heart to resist unscrewing of the primary fixation feature.

Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an outer tubular member including a lumen extending from a proximal end to a distal end thereof and an intermediate tubular member including a lumen extending from a proximal end to a distal end thereof. A distal holding section may be coupled to the intermediate tubular member and define a cavity therein for receiving a proximal implantable leadless pacing device and a distal implantable leadless pacing device in a linear arrangement. The distal holding section may have a proximal body portion and a distal body portion. The proximal body portion may be more flexible than the distal body portion. An inner tubular member including a lumen extending from a proximal end to a distal end thereof may be slidably disposed within the lumen of the intermediate tubular member.

Systems and methods for the treatment of gastroesophageal reflux disease (GERD) include at least one electrically stimulating electrode coupled to a pulse generator. Individuals with GERD are treated by implanting a stimulation device within and/or proximate the patient's lower esophageal sphincter, gastric fundus, or other nearby gastrointestinal structures and applying electrical stimulation to the patient's lower esophageal sphincter and/or fundus, in accordance with certain predefined protocols. Electrical stimulation provided by the disclosed systems results in an increase in the length of the high pressure zone of the LES and/or modulation of the receptive relaxation response of the fundus to decrease gastric pressure, creating a longer barrier to the reflux of gastric contents or increasing functional lower esophageal pressure respectively, thereby treating GERD.

The invention features methods and devices useful for stimulating brain tissue in a subject via electrodes within cranial bone. These methods and devices may be utilized for the detection, prevention, and/or treatment of neurological disorders via electric stimulation. Additionally, the methods and devices disclosed herein may be useful for the treatment, inhibition, and/or arrestment of the growth of tumors.

An example of a system for programming neurostimulation according to a stimulation configuration may include stimulation configuration circuitry, volume definition circuitry, stimulation effect circuitry, and recording circuitry. The stimulation configuration circuitry may be configured to determine the stimulation configuration. The volume definition circuitry may be configured to determine stimulation field model(s) (SFM(s)) each representing a volume of tissue activated by the neurostimulation. The stimulation effect circuitry may be configured to determine a stimulation effect type for each tagging point specified for the SFM(s) and to tag the SFM(s) at each tagging point with the stimulation effect type determined for that tagging point. The stimulation effect type for each tagging point is a type of stimulation resulting from the neurostimulation as measured at that tagging point. The recording circuitry may be configured to generate SFM data representing the determined SFM(s) with the stimulation effect type tagged at each tagging point.

In one aspect, an apparatus for stimulating and/or monitoring a nerve is described herein. In some embodiments, the apparatus comprises a top substrate layer, a bottom substrate layer in facing opposition to the top substrate layer, and a channel disposed between the top substrate layer and the bottom substrate layer. The apparatus further comprises a plurality of electrodes disposed on one or more interior surfaces of the channel. Additionally, the channel is defined by the top substrate layer, the bottom substrate layer, and a retaining wall extending at least partially between the top substrate layer and the bottom substrate layer. The retaining wall retains the nerve within the channel.

The present disclosure relates to the treatment of patients with Parkinson's Disease using subthalmic nucleus deep brain stimulation to a specific region of the brain. By positioning the electrode in the margin of the dorsal-lateral and anterior region of the subthalamic nucleus, improved benefits are obtained.

A system and method for altering bone growth on and within an orthopedic implant that includes an implant body; a plurality of electrodes, wherein each electrode is at least partially embedded in the implant body, and comprises: a set of primary electrodes comprising at least one electrode, wherein a non-embedded segment of each primary electrode is proximal to a bone growth region, a set of secondary electrodes comprising at least one electrode, wherein a non-embedded segment of each secondary electrode is distal to the bone growth region, and wherein the plurality of electrodes are configured to function in a stimulation operating mode, such that a subset of primary electrodes function as cathodes and a subset of secondary electrodes function as anodes; a control system comprising a processor, and circuitry that connects to the plurality of electrodes; and a power system.

An implantable medical device (IMD) and method are provided. The IMD includes a sensing channel configured to obtain biological signals indicative of biological behavior of an anatomy of interest over a period of time. The biological behavior has a feature of interest that repeats over time. The biological signals have clinically relevant (CR) segments that include information related to the feature of interest. The biological signals have non-clinically relevant (NCR) segments that do not include information related to the feature of interest. At least one of circuitry or a processor are configured to compare the biological signals to an amplitude window to distinguish the CR segments from the NCR segments, save to memory the CR segments and delete the NCR segments, save to memory time information indicative of a duration of the NCR segments that were deleted and to form a lossy compressed data set for the biological signals.

Electrodes that are configured to apply energy within the tissue while moving relative to the tissue. The apparatuses (devices, assemblies, systems) described herein may be configured with one or more electrodes that may move slightly in oscillatory movement and/or rotation relative to the tissue. The apparatuses described herein may be used to apply energy to a patient while minimizing or preventing the unintended modification of the tissue adjacent to the electrode, such as by arcing.