Methods, implantable devices, and systems for treating a cancer or inhibiting cancer growth or recurrence in a subject are described herein. Such methods can include electrically stimulating a thoracic splanchnic nerve (such as a greater splanchnic nerve) of the subject with a plurality of electrical pulses emitted from one or more electrodes m electrical communication with the splanchnic nerve, wherein the plurality of electrical pulses triggers one or more action potentials in the splanchnic nerve to increase circulating natural killer (NK) cells in the subject. An implantable device may include one or more electrodes configured to be in electrical communication with a thoracic splanchnic nerve of a subject with cancer, and be configured to operate the one or more electrodes to electrically stimulate the splanchnic nerve with a plurality of electrical pulses that triggers one or more action potentials in the splanchnic nerve that increase circulating NK cells.

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

A system and method for altering bone growth on and within an orthopedic implant comprising an implant body, wherein the implant body comprises an exterior surface and an interior surface defining an internal cavity of the implant body, a plurality of electrodes, wherein each electrode is at least partially embedded in the implant body, and comprises at least, a first set of the plurality of electrodes 116, composed of a first material, and a second set of the plurality of electrodes, composed of a second material; and a control system, comprising a processor and circuitry that connects to the plurality of electrodes, wherein the processor, through operating modes, provides machine instructions to control direction and magnitude of current traveling through each electrode from the plurality of electrodes; and a power system, comprising a power source and circuitry that provides electrical power for function of the plurality of electrodes.

In some examples, the disclosure describes a medical assembly that includes a stent including a primary electrode, where the stent is configured to expand from a collapsed configuration to an expanded configuration, a secondary electrode, and an energy source configured to deliver an electrical signal between the primary electrode and the secondary electrode through a fluid in contact with the primary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

In some examples, the disclosure describes a medical assembly that includes a stent including a primary electrode, where the stent is configured to expand from a collapsed configuration to an expanded configuration, a secondary electrode, and an energy source configured to deliver an electrical signal between the primary electrode and the secondary electrode through a fluid in contact with the primary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

A closed-loop implantable neurostimulator system for mitigating chronic pain, the closed-loop implantable neurostimulator system including a neuromodulation device comprising one or more electrodes configured to measure a physiological signal of a subject and deliver an electrical stimulation signal to a target area in the subject and a controller, in communication with the one or more electrodes, comprising a processor and a computer-readable memory storing a trained healthy computer model, the controller configured to analyze the physiological signal that is measured using the trained healthy computer model to identify a corrective electrical stimulation signal that, when delivered by the one or more electrodes to the target area, reduces pathological neuronal events in the target area while preserving acute pain response.

An implantable device includes a flexible cable, a circuit chip, a fluid adhesion layer, and a vapor deposited layer. The flexible cable includes a lead-in part, a stimulation part and a connection part connected between the lead-in part and the stimulation part. The circuit chip is fixed to a surface of one side of the lead-in part, and is electrically connected to the lead-in part. The fluid adhesion layer is adhered to an outer side of the circuit chip and an outer side of the lead-in part. The vapor deposited layer (4) is directly deposited on an outer side of the fluid adhesion layer.

Methods and systems for treating sleep apnea using electrical stimulation to a patient's upper and/or lower respiratory nerve or muscle are described. A stimulation regimen can be used to achieve upper airway patency and/or rhythmic air flow in a coordinated fashion during sleep. In some cases, diaphragm activity is monitored to determine whether sufficient upper airway patency and/or rhythmic air flow is achieved and maintained. The stimulation regimen may be adjusted based on the diaphragm activity. In some cases, the system includes modularized components so that the components can be customized to an individual's needs.

The present disclosure provides embodiments of devices that are useful in the structural remodeling of various parts of the cardiovascular system, most notably the heart. Certain of the disclosed devices relate to RAMIN procedures (“remodeling and ablation using myocardial interstitial navigation”). RAMIN procedures, as described herein, represent a new family of non-surgical catheter-based procedures in order to accomplish ablation, drug delivery, re-shaping, pacing, and related structural heart interventional procedures, as desired.