Described herein are methods and systems for calculating a corrected Fractional Flow Reserve (FFR). An illustrative method includes delivering a first pressure sensing device including a pressure sensor to a location in a blood vessel having a stenosis, positioning the pressure sensor distal to the stenosis, measuring the distal pressure, measuring the proximal pressure, and calculating a corrected FFR using the measured proximal and distal pressures and applying a correction factor or correction equation. The corrected FFR may approximate a FFR that would have been obtained if the pressure measured downstream of the stenosis was measured using a second pressure sensing device having a second maximum cross-sectional area in a distal portion of the second pressure sensing device that is different from the first maximum cross-sectional area.

A medical device system for concurrent power and data transfer comprises an elongated conductive member. At least a portion of the elongated conductive member is configured for insertion within an intraluminal space. One or more sensors that are in electrical connection with the elongated conductive member. The medical device system uniquely allocates each of the plurality of unique contiguous segments within a signal space to one of (i) one or more power channels or (ii) one or more signal channels. The medical device system then sends the electrical signals, via the elongated conductive member, to one or more sensors that are in electrical connection with the elongated conductive member. The medical device harvests energy from the electrical signals. The medical device system isolates transmitted data signals within at least one of the one or more signal channels the data signals generated by the one or more sensors.

An implantable device system includes an implantable device, such as an annuloplasty ring, for controlling at least a shape and/or size of a heart valve annulus. The implantable device includes an arcuate body and an adjustment system configured to adjust the shape and/or size of the arcuate body. An adjustment tool is configured to be coupled to the adjustment system so that the adjustment tool can be used to activate and control adjustment of the arcuate body. A sensor system is configured to be coupled to the implantable device. The sensor system includes a first sensor configured to measure physiological data at an inflow portion of the valve annulus when the implantable device is implanted into the valve annulus, and a second sensor configured to measure physiological data at an outflow portion of the valve annulus when the implantable device is implanted into the valve annulus.

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. For example, such a device may be used to measure fractional flow reserve (FFR) across a stenotic lesion in order to assess the severity of the lesion. The sensor delivery device has a distal sleeve configured to pass or slide over a standard medical guidewire. Some distance back from the sensor and distal sleeve, the device separates from the guidewire to permit independent control of the sensor delivery device and the guidewire. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.

The invention relates to a device (150) for monitoring the state of health of a patient (100), wherein the device (150) comprises an input interface (160) for inputting a first pressure signal (145) and a second pressure signal (155) and a processing unit (165) for processing the first pressure signal (145) and the second pressure signal (155) in order to determine a processing value (170) in order to monitor the state of health of the patient (100) based the processing value (170).

A system includes: an aortic pressure sensor configured to measure aortic blood pressure of an individual; a distal sensor configured to measure a parameter in a blood vessel; a receiver configured to receive both (i) a signal representing the measured aortic blood pressure value, and (ii) a signal representing the parameter, the receiver comprising a display configured to display data that is based on at least the measured aortic blood pressure value and the measured parameter; and a communication interface configured to (i) receive a signal representing the measured aortic blood pressure value from the aortic pressure sensor via a wired connection, (ii) provide a signal representing the measured aortic blood pressure value to a monitoring device via a wired connection, and (iii) send a signal representing the measured aortic blood pressure value to the receiver via a wireless connection.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and/or regulate a temperature of the bodily fluid flowing therethrough.

An eavesdropping arrangement for acquiring a measured physiological variable of an individual includes a receiver and a communication interface in a housing separate from the receiver. The communication interface is positioned along a communication link between a first sensor, which is configured to measure aortic blood pressure and to provide a signal representing measured aortic blood pressure, and a central monitoring device configured to monitor the measured aortic blood pressure. The communication interface includes a connection to the communication link that permits the communication interface to eavesdrop on the signal representing measured aortic blood pressure such that information representing measured aortic blood pressure is sent to the receiver while allowing the central monitoring device to receive and use the signal representing measured aortic blood pressure.

Devices and methods for blood flow enhancement and hemodynamic power monitoring are provided. A blood flow enhancement device includes a pump system configured to be coupled to a central vasculature of a subject during cardiopulmonary resuscitation (CPR). The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR. The pumping mechanism being operated concurrently with the CPR. The hemodynamic power monitor is configured to control a chest compression device and an active valve.

The invention relates to evaluation of maturity of arteriovenous (AV) fistula using guidewires that measure intravascular blood flow and/or pressure. The invention provides methods of evaluating AV fistula maturation using an instrumented guidewire to measure intravascular flow and/or pressure. By using a small diameter guidewire that does not interfere substantially with the flow, an accurate measurement can be made that is useful for identifying when a fistula is mature and therefore ready to be used for hemodialysis. The flow of blood through the fistula is measured using the guidewire and the measured flow and/or pressure of blood is used to determine if the fistula is mature.