Device for detecting characteristic signals of tissues and materials and methods for calculating thereof. Apparatus and methods for detecting the presence of tissue (skin) in pulse oximeter are disclosed. Specifically, analysis using optical techniques are used to identify characteristic signals of different compositions of matter. The present application discloses using a plurality of photodetectors at different distances from a source to measure light scattering through a variety of materials, and more specifically, to detect the presence of tissue.

A wearable device and the accompanying method for the determination of continuous pulsatile BP are described. The absolute values can be obtained in the initial phase and how a transfer function can transform the BP-signal obtain at the finger or wrist to correct BP-values corresponding to the brachial artery and at heart level. The wearable device contains an orthostatic level-correcting element, which can measure the vertical distance between heart level and finger/wrist level, where the actual measurement takes places. The wearable device may be in the form of a ring, a watch, or a bracelet. Further, the wearable device has elements for wirelessly transmitting signals to host devices such as a smart phone, tablet or other computers.

A pulse data detecting apparatus, pulse data detecting method, and pulse data detection program are provided capable of suppressing an influence of the condition of the body surface to be measured and obtaining an appropriate measurement result under a wide range of conditions. In the present invention, a blood-flow-suppressing-projection protrusion-control mechanism section causes a blood-flow-suppressing projection to protrude to press or compress the body surface to suppress a blood flow on a downstream side, thereby increasing a blood pressure of a measurement region at the time of measurement. A light-receiving element receives reflected light of light applied from a light-emitting element to a skin surface, and outputs an electrical signal. Increasing the blood pressure of the measurement region enables to obtain an output signal at a sufficient output level from the light-receiving element. A CPU calculates a pulse rate based on the output signal from the light-receiving element.

The present disclosure provides for specific shapes and combinations of the compression members amenable to the safest, yet most effective compression of the carotid and vertebral arteries aimed at prevention of embolic stroke. An associated method of achieving an optimal compression of said arteries for the purpose of stroke prevention is provided.

Disclosed is a finger cuff that is attachable to a patient's finger to be used in measuring the patient's blood pressure by a blood pressure measurement system utilizing a volume clamp method. The finger cuff comprises a wrappable portion that wraps around a patient's finger. The wrappable portion includes a bladder and a light emitting diode (LED) and photodiode (PD) pair. The finger cuff further comprises a plurality of tubules mountable on an exterior of the wrappable portion. The tubules are inflatable to provide pressure to the wrappable portion of the finger cuff to the patient's finger and to provide tightness of the wrappable portion of the finger cuff to the patient's finger. When the finger cuff is placed around the patient's finger, the bladder and the LED-PD pair aid in measuring the patient's blood pressure by the blood pressure measurement system utilizing the volume clamp method.

The invention relates to medicine. The inventive method for non-evasively determining an endothelial function consists in reducing a transmural pressure in a limb, recording the amplitude of plethysmographic signals at different pressures, determining the pressure of a maximum plethysmographic signal amplitude, reducing the pressure to a value corresponding to the specified percentage of the maximum amplitude, carrying out an occlusion sample in the course of which a pressure higher by at least 50 mm Hg than the systolic pressure of a tested patient is produced in a cuff arranged proximally to the located limb area, wherein the occlusion is carried out during at least 5 minutes. The inventive device for carrying out said method comprises a sensory unit, a pressure producing unit, an electronic unit constructed in such a way that it makes it possible to measure the cuff pressure corresponding to the maximum plethysmographic signal amplitude and a unit for controlling the pressure producing unit in such a way that the cuff pressure corresponding to the amplitude of a plethysmographic signal, which represents a specified percentage of the maximum amplitude, is attained. The sensory unit is connected to the electronic unit to the output of which the pressure producing unit is connected.

Disclosed is a finger cuff that is attachable to a patient's finger to be used in measuring the patient's blood pressure by a blood pressure measurement system utilizing a volume clamp method. The finger cuff comprises a bladder configured to exert pressure on the patient's finger. The finger cuff further comprises a plurality of light emitting diodes (LEDs) and a plurality of photodiodes (PDs) that respectively align with one another to form a plurality of LED-PD pairs. When the finger cuff is placed around the patient's finger, the bladder and the plurality of LED-PD pairs aid in measuring the patient's blood pressure by the blood pressure measurement system utilizing the volume clamp method.

Disclosed is a finger cuff attachable to a patient's finger to be used in measuring the patient's blood pressure by a blood pressure measurement system utilizing the volume clamp method. The finger cuff may include a light emitting diode (LED) and photodiode to form an LED-PD pair to perform measurements of a plethysmogram signal to aid in measuring the patient's blood pressure; and a bladder. The bladder includes a bottom portion that abuts only the bottom portion of the patient's finger to apply concentrated pressure only on the bottom of the patient's finger near both of the patient's two arteries, wherein, when the finger cuff is placed around the patient's finger, the bottom portion bladder and LED-PD pair aid in measuring the patient's blood pressure by the blood pressure measurement system.

A noninvasive method for estimating a concentration of a target analyte in a sample comprises generating a first and second (reference) radiation, a principal radiation and a target analyte carrier detection radiation; directing the first, second, principal and the target analyte carrier detection radiations at the sample which includes the target analyte; and detecting a first, second, principal and target analyte carrier detection amount of the radiation that leaves the sample. The method further comprises modulating the sample thickness in order to achieve time-wise or spatial target analyte concentration variation within the sample. The method further comprises generating first, second, principal and target analyte carrier detection measurement data based respectively on the first, second, the principal and the target analyte carrier detected amounts of radiation; numerically processing the first, second, principal and target analyte carrier detection measurement data to obtain a weighted combination of the first measurement data and the second measurement data that balances the principal measurement data with respect to a sample background; and estimating the concentration of the target analyte based on the difference between the balanced weighted combination of the first measurement data and the second measurement data vs. the principal measurement data.

In one implementation, a multi-vital-sign smartphone system detects multiple vital signs from sensors such as a digital infrared sensor, a photoplethysmogram (PPG) sensor and at least one micro dynamic light scattering (mDLS) sensor, and thereafter in some implementations the vital signs are transmitted to, and stored by, an electronic medical record system.