The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Transdermal sampling and analysis devices, methods, and systems are provided. The transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, at least a first sensing electrode and a second sensing electrode, a counter/reference electrode, and a plurality of well areas between a base structure and a lid structure. The at least one disruptor may be configured to generate a localized heat capable of altering permeability characteristics of a subject's skin. The plurality of well areas may be configured to receive a biological fluid sample. Within each well area, the first sensing electrode may be coated with a first analyte sensing layer, the second sensing electrode may be coated with a second analyte sensing layer different from the first analyte sensing layer, and the counter/reference electrode may be configured to be electrically connected to each of the first and second sensing electrodes.

A wearable measuring device is provided. The wearable measuring device includes a wearable element, a liquid-transferring element, a bio-sensing electrode, a flow-sensing electrode, and a meter. The wearable element has an opening. The liquid-transferring element is disposed in the wearable element and has a sampling portion exposed to the outside through the opening. The bio-sensing electrode and the flow-sensing electrode are connected to a first position and a second position of the liquid-transferring element. The meter is disposed on or in the wearable element and is electrically connected to the bio-sensing electrode and the flow-sensing electrode.

Devices and methods for low-latency analyte quantification enabled by the implementation of a microneedle-based analyte-selective sensor operating in the dermis or viable epidermis are disclosed herein. The sensing element of the device is contained within the microneedle-based analyte-selective sensor and configured to penetrate the stratum corneum of the skin and become positioned in the viable epidermis or dermis of the wearer such that the sensing element is located a spatial distance no greater than 500 micrometers from the plexus of the dermis of the wearer.

A microneedle device comprising a membrane having an adhesive thereon and a microneedle substrate adhered to the membrane via the adhesive. The microneedle substrate may have a plurality of microneedles coupled thereto, or the microneedle substrate can comprise the plurality of microneedles. The microneedle device can be mated with a reagent container and the microneedles aligned with wells on the reagent container said wells configured to hold reagents thus comprising a system for detecting opioids or other drugs. In another embodiment, the device comprises a sweat-absorbent swatch adhered to a membrane. This embodiment can be mated to a screening pad comprising blisters of reagents on the base layer of the screening pad. Upon mating, a needle device can be used to pierce the blisters such that the reagents are released and react with the sweat absorbent swatch to indicate the presence of opioids or other drugs.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.