A continuous sensing device for measuring at least one analyte in interstitial fluid is provided. The device (100) includes at least one feature (114) configured to be inserted into a body, and specifically, the at least one feature configured to be inserted into a skin (12) of the body. The at least one feature is at least partially coated with at least one electrode (120) functionalized with an aptamer sensing monolayer layer (122), and the aptamer sensing monolayer layer includes an aptamer with attached redox couples and passivating material. The at least one feature is configured to provide at least one of a resistance to abrasion effect or a pressure effect for the aptamer sensing monolayer when the feature is placed into the body.

A system is described to create customized unique identification (UID) codes combined with customized printable optical or NFC sensors and to combine these unique sensors and unique IDs with unique environmental events, traceability, unique data from cell phones (including geolocation) and person-specific unique indicators such as biomarkers to create completely unique, low cost and proprietary printable genomic and environmental blockchain sensor networks for the Internet of Things (IoT), counterfeit identification, healthcare, pharmaceutical applications and small payment transactions worldwide.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Disclosed herein is a combination of an automated insulin delivery system and a continuous glucose monitor integrated into a single, wearable package. The system may use any combination of delivery methods and detection methods, wherein the delivery methods include a cannula, a microneedle array, and a transdermal patch, and wherein the detection methods include electrochemical methods, opto-fluorescent methods, and spectrographic methods.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

The present invention relates to a body monitoring system comprising a patch, the patch comprising a main body, the main body comprising a second face suitable for facing the skin of a user, the patch comprising an adhesive layer at least partially covering the second face, and a peelable cover covering the adhesive layer, the peelable cover comprising at least two separate portions, the portions being adjacent to each other, the main body and the adhesive layer comprise a central portion forming an opening suitable for receiving the capsule, the opening having a maximum diameter greater than 2 mm, preferably greater than 5 mm.

A wearable device utilizing flexible electronics is disclosed. The wearable device may comprise a flexible matrix material and may include sensors for measuring biometric measurements of an individual, an accelerometer for measuring an acceleration of a body part to which the wearable device is attached, a wireless transmitter, a flexible power source, and a microcontroller. During an activity, the microcontroller may receive signals from the sensors including the biometric measurements, and signals from the accelerometer including acceleration and force measurements associated with the individual. The microcontroller may convert the signals into digital signals and transmit the signals to a computing device for analysis. The computing device may analyze the digital signals to determine a performance metric for the individual. The performance metric may be compared to baseline data for the individual to determine a fatigue level, injury risk, or an adjustment to be made by the individual during the activity.

The present disclosure is directed to microneedle patches for direct sampling and ultrasensitive detection of protein biomarkers in dermal interstitial fluids. The microneedle patches are comprised of polymers with high protein absorption capability (e.g. polystyrene) and are modified with capture biorecognition elements that are specific to target analytes in the interstitial fluid (ISF). Systems and methods are further provided for detection of a target ISF analyte obtained by in vivo sampling of the ISF using a microneedle patch.

Provided herein are devices and systems for measuring a dosage of a medication used by a subject. Further provided herein are methods, systems, and media for dosing regulation and prescription compliance.

Microneedles for detecting targets are described. The microneedles may be made of a hydrogel and a probe coupled to the hydrogel for generating a measurable signal in the presence of the target. The hydrogel microneedles may be used for in-situ detection of targets, such as biomolecules found in interstitial fluid. Also described are methods or producing hydrogel microneedles, articles and apparatus comprising hydrogel microneedles, and methods and uses of the same. The hydrogel microneedles may be used for biosensing, such as in transdermal patches for detecting biomarkers in a subject. The biosensors may be used for continuous, real-time tracking of targets in-situ, without requiring further reagents or processing steps.