A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig's disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig’s disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Disclosed is a device suitable for measuring the brain activity signals of an individual, the device being intended to be placed on the head of the individual and having a structure intended to carry sensors, the structure allowing the position of the sensors to be adjusted. The structure of the device has: a deformable central support, which is able to adapt to the curvature of the head and is intended to be positioned along the head, preferably on the median plane of the cranium; flexible guides, which extend laterally with respect to the central support and are spaced apart from each other; sensor supports, which are rigidly connected and fixed to the flexible guides, in adjustable positions along the flexible guides; and a system for tightening the flexible guides.

An apparatus and a method is provided for detecting biometric signals of a driver and classifying the driver into a normal state or a fatigued state based on the biometric signals. An apparatus may include: a biometric signal measuring part configured to measure the biometric signals including a blood flow rate of a brain of the driver using an electro-encephalography (EEG), an electro-cardiography (ECG), and a functional near-infrared spectroscopy (fNIRS) of the driver; a biometric signal integral part configured to integrate the measured biometric signals, to extract characteristics of the respective biometric signals from the measured biometric signals and to then integrate the extracted characteristics, or to classify the extracted characteristics of the biometric signals and to then integrate the classified characteristics; and a driver state detecting part configured to detect the state of the driver based on the integrated biometric signals.

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

fNIRS may be used in real time or near-real time to detect the mental state of individuals. Phase measurement can be applied to drive an adaptive filter for the removal of motion artifacts in real time or near-real time. In this manner, the application of fNIRS may be extended to practical non-laboratory environments. For example, the mental state of an operator of a vehicle may be monitored, and alerts may be issued and/or an autopilot may be engaged when the mental state of the operator indicates that the operator is inattentive.

A system for measuring an analyte within a cerebral venous blood flow is provided. The system includes an excitation light source, a light delivery element, an ultrasound receiving mechanism, and a controller. The excitation light source is configured to produce one or more wavelengths operable to cause an analyte to photoacoustically produce at least one ultrasonic signal. The light delivery element is disposed on a posterior region of a human head, and receives light from the light source. The ultrasound receiving mechanism is disposed on an anterior region of the head. The mechanism includes at least one ultrasonic receiver. The controller is configured to control the excitation light source to selectively produce the excitation light, and to measure an amount of the analyte present within the cerebral venous blood flow.

A regional oximetry pod drives optical emitters on regional oximetry sensors and receives the corresponding detector signals in response. The sensor pod has a dual sensor connector configured to physically attach and electrically connect one or two regional oximetry sensors. The pod housing has a first housing end and a second housing end. The dual sensor connector is disposed proximate the first housing end. The housing at least partially encloses the dual sensor connector. A monitor connector is disposed proximate a second housing end. An analog board is disposed within the pod housing and is in communications with the dual sensor connector. A digital board is disposed within the pod housing in communications with the monitor connector.

An imaging device includes a light source, an image sensor, and a controller. Each pixel of the image sensor includes first and second accumulators and a discharger. The controller, while a component of light from the light source reflected by the surface of a target is incident on the image sensor, causes the accumulators to accumulate signal charge not discharged to the discharger, by setting the image sensor so that signal charge is discharged to the discharger, while a component having scattered inside the target is incident on the image sensor, causes the first accumulator to accumulate signal charge by setting the image sensor so that signal charge is not discharged to the discharger and signal charge is accumulated in the first accumulator, and causes the image sensor to generate first and second signals that are respectively based on signal charge accumulated in the first and second accumulators.

A device is provided for the optical measurement of a living body. For the purpose of separating a signal coming from the change in hemodynamics in a deep part from a signal coming from the change in hemodynamics in skin, light irradiation sites and light detection sites are positioned so that the measurement is achieved employing at least two SD distances. At two SD distances, the change in a logarithmic value of the detected light at every time point is determined employing a logarithmic value of the amount of detected light under specific conditions or at a specific time point as a starting point. A gradient value for a differential SD distance, which is a difference between the amount of change obtained by the measurement at a longer SD distance and the change obtained by measurement at a shorter SD distance, is used as a measurement amount.