A micro-volume blood transfer device to facilitate the collection of small volumes of clean arterial blood from patients who may be volume restricted for blood loss such as low-birth weight infants.

Devices and methods for extraction and processing of substantia gelatinea funiculi umbilicalis (Wharton's Jelly) from an umbilical cord. Isolated pluripotent cell compositions and methods of using the same are also provided.

The present disclosure provides an apparatus, and methods of using same, for collecting blood from an umbilical cord in a sterile environment that includes an umbilical cord retaining assembly and a blood collection assembly rotatably connected to the umbilical cord retaining assembly. A cord cutting blade, which is carried by the blood collection assembly, functions to cut the umbilical cord when the blood collection assembly is rotated relative to the umbilical cord retaining assembly. After the umbilical cord is cut, blood flows by force of gravity into the blood collection region of the blood collection assembly to which a blood collection bag can be interconnected.

A device and method for the collection of blood from an umbilical cord. Unlike other devices traditionally used which make use of a needle for insertion through the cord tissue and into the umbilical vein, the present device includes a long probe to be inserted into the umbilical vein after the umbilical cord is cut. The device additionally includes a fastening component to be tied around the umbilical cord under the position of the head of the device once inserted to fasten it in place. The device has a wide aperture for faster flow of the blood at a constantly tapered angle to reduce shear forces that may damage cells. Additionally, the head of the device is angled for easy insertion into the umbilical vein and is ribbed to resist falling out of the vein.

A cord blood collection device (1), the device (1) comprising a chamber (2) in fluid communication with a tapered nozzle (4); and in which the tapered nozzle further comprises at least one step (20) along its length.

The present invention relates to devices and processes for introducing and maintaining a port in an umbilical vessel and uses thereof. Further the invention relates to kits comprising said device and the uses thereof.

Umbilical cord sensors for monitoring biomarkers and other information associated with an umbilical cord are provided. Some exemplary embodiments of sensors include both an outer body and expandable inner body, with both bodies being disposed at least partially around an umbilical cord, the inner body being disposed within the outer body. The expandable inner body defines a receiving channel for receiving the umbilical cord, and is selectively expanded and contracted to engage and disengage with the umbilical cord. One or more biosensors and/or one or more sampling features can be included as part of the umbilical cord sensors, with the biosensors measuring one or more parameters and the sampling features obtaining one or more biomarkers associated with the umbilical cord. Exemplary methods of using umbilical cord sensors during the childbirth process are also provided, among other sensor configurations and methods of use.

A novel blood collection device is described to secure a needle in place in a placenta or umbilical cord to prevent needle stick before, during, and after cord blood collection procedure.

A decision support tool is provided for predicting the neonatal vitality scores of a fetus during delivery, the scores being an indicator of future health for the infant anticipated to be born within a future time interval, measured as time to birth. The predicted neonatal vitality score is determined from measurements of physiological variables monitored during labor, such as uterine activity and fetal heart rate. Fetal heart rate variability and patterns may be detected and computed using the monitored physiological variables, and neonatal vitality scores may be predicted based, at least in part, on the variability metrics and fetal heart rate patterns. Scores may be predicted for different delivery methods, such as vaginal delivery or cesarean delivery, for different time-to-birth intervals. In this way, these scores may be used for decision support for care plans during labor, such as increased monitoring and/or modifying the delivery type.

The present disclosure provides an apparatus, and methods of using same, for collecting blood from an umbilical cord in a sterile environment that includes an umbilical cord retaining assembly and a blood collection assembly rotatably connected to the umbilical cord retaining assembly. A cord cutting blade, which is carried by the blood collection assembly, functions to cut the umbilical cord when the blood collection assembly is rotated relative to the umbilical cord retaining assembly. After the umbilical cord is cut, blood flows by force of gravity into the blood collection region of the blood collection assembly to which a blood collection bag can be interconnected.