Provided herein is a stimulating device being equipped with an electrode element recording and stimulating nerve signals for diagnosis and treatment of chronic pain or Alzheimer's disease and, most particularly, to a stimulating device providing electrical stimulation for chronic pain or Alzheimer's-causing proteins or measuring bio signals. The stimulating device includes a controller, a substrate being coupled to a bottom of the controller, and having a power receiving and signal delivering electrode being mounted thereon as a single body or being distinctively mounted thereon, wherein the power receiving and signal delivering electrode is capable of wirelessly receiving power and wirelessly delivering bio signals, and an electrode element being coupled to a bottom of the substrate and being capable of delivering electrical stimulation to tissues inside a body.

Controlling a neural stimulus comprises applying the neural stimulus to a neural pathway in order to give rise to an evoked action potential on the neural pathway, the stimulus being defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured, and from the measured evoked response a feedback variable is derived. Loop backoff behaviour is adjusted by applying a non-identity function to the feedback variable to produce a revised feedback variable, and completing a feedback loop by using the revised feedback variable to control the at least one stimulus parameter so as to maintain the feedback variable at a setpoint. Additionally, or alternatively, loop gain can be adjusted in response to a change in the loop setpoint, and/or a logarithm of the stimulus parameter can be controlled.

Controlling a neural stimulus comprises applying the neural stimulus to a neural pathway in order to give rise to an evoked action potential on the neural pathway, the stimulus being defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured, and from the measured evoked response a feedback variable is derived. Loop backoff behaviour is adjusted by applying a non-identity function to the feedback variable to produce a revised feedback variable, and completing a feedback loop by using the revised feedback variable to control the at least one stimulus parameter so as to maintain the feedback variable at a setpoint. Additionally, or alternatively, loop gain can be adjusted in response to a change in the loop setpoint, and/or a logarithm of the stimulus parameter can be controlled.

A cautery safety controller can include a first input to receive a cautery power signal; a first output coupled to a nerve stimulator system; a second input coupled to receive a nerve detected signal; a zero-crossing detector coupled to receive the cautery power signal via the first input and output a nerve sense enable signal via the first output to the nerve stimulator system in response to detecting a zero crossing of the cautery power signal; and a nerve detection decision unit coupled to receive the nerve detected signal via the second input, generate a stop operation signal, and output the stop operation signal via a second output. A cauterizing pencil can be provided with a tap line for providing the cautery power signal. Alternatively, a cautery pad can be provided with a sense electrode for providing the cautery power signal.

A neural probe structure includes a probe that is inserted into a subject, a body to support a rear end of the probe, at least one light source included in the body, a photo diode formed in the probe, and an optical waveguide extending from the at least one light source in the body to the photo diode of the probe, wherein the photo diode is formed at a smaller height than the optical waveguide.

An implantable electrical contact arrangement comprising at least one electrode element entirely integrated into a carrier substrate of a biocompatible, electrically insulating material, and at least one freely accessible electrode surface enclosed by the biocompatible, electrically insulating carrier substrate. Within a sub-space which does not contain an electrode element, the carrier substrate surrounds at least one space containing at least one material with a modulus of elasticity differing from a modulus of elasticity of the material of the carrier substrate.

An implantable electrical contact arrangement comprising at least one electrode element entirely integrated into a carrier substrate of a biocompatible, electrically insulating material, and at least one freely accessible electrode surface enclosed by the biocompatible, electrically insulating carrier substrate. Within a sub-space which does not contain an electrode element, the carrier substrate surrounds at least one space containing at least one material with a modulus of elasticity differing from a modulus of elasticity of the material of the carrier substrate.

A method for detecting and identifying a patient physiological response includes stimulating, via a stimulating electrode coupled to a patient, one or more nerves of the patient. The method includes recording, via a recording electrode coupled to the patient, a plurality of resultant electrical waveforms. The method includes determining, based on the plurality of resultant electrical waveforms, whether at least a subset of the plurality of resultant electrical waveforms includes a patient physiological response. The determining includes comparing the subset of resultant electrical waveforms of the plurality of resultant electrical waveforms to a model waveform from a database of a plurality of model waveforms. The determining includes determining, based on the comparison, a comparison feature. The comparison feature indicates whether the patient physiological response exists in the subset. The method includes displaying, via a display, an indication that the patient physiological response exists in the subset of resultant electrical waveforms.

A method for detecting and identifying a patient physiological response includes stimulating, via a stimulating electrode coupled to a patient, one or more nerves of the patient. The method includes recording, via a recording electrode coupled to the patient, a plurality of resultant electrical waveforms. The method includes determining, based on the plurality of resultant electrical waveforms, whether at least a subset of the plurality of resultant electrical waveforms includes a patient physiological response. The determining includes comparing the subset of resultant electrical waveforms of the plurality of resultant electrical waveforms to a model waveform from a database of a plurality of model waveforms. The determining includes determining, based on the comparison, a comparison feature. The comparison feature indicates whether the patient physiological response exists in the subset. The method includes displaying, via a display, an indication that the patient physiological response exists in the subset of resultant electrical waveforms.

Exemplary embodiments of the present invention provide for an integrated electrophysiology amplifying apparatus, computer-accessible medium, system and method for use thereof. In accordance with certain exemplary embodiments of the present disclosure, an integrated electrophysiology amplifying system can include: a pipette interface for receiving a pipette or sharp microelectrode; and an integrated circuit having (i) an amplifier coupled to the pipette interface and configured to control a current through a connected pipette or record a cell membrane voltage and (ii) at least one compensation circuit using negative feedback; wherein the integrated circuit and pipette interface are physically integrated within a common housing.