A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

A target peripheral nerve is treated by providing a real-time fluorescent image of a tissue region where the target peripheral nerve has an enhanced appearance in the fluorescent image. A treatment element is advanced from an adjacent body lumen or cavity through the tissue region or externally aimed toward the peripheral nerve while viewing the fluorescent image, and the peripheral nerve is treated using the treatment element.

A system for providing neuronal stimulation signals configured to elicit sensory percepts in the cortex of an individual, comprising means for obtaining spatial information relating to the actual or planned position of a neuronal stimulation means relative to afferent axon(s) targeting sensory neuron(s) in the cortex of the individual and means for determining a neuronal stimulation signal to be applied to the afferent axon(s) via the neuronal stimulation means based at least in part on the obtained spatial information.

A system for communicating conceptual information to an individual, comprising means for selecting a neuronal stimulation signal to be applied to afferent axon(s) targeting sensory neuron(s) in the cortex of the individual, wherein the neuronal stimulation signal corresponds to the conceptual information to be communicated and means for transmitting the neuronal stimulation signal to the neuronal stimulation means of the individual.

This disclosure relates to a method for automating segmentation of corneal nerve fibers based on a deep learning approach to segmentation. Methods of the invention offer more robust results by utilizing the power of supervised learning methods in concert with the pre- and post processing techniques documented.

A method for determining peripheral nerve stimulation during MR imaging of a patient in a MR scan unit for a MR pulse sequence is described. In the method, a plurality of model-based candidate stimulations are determined dependent on a unit vector potential of the gradient magnet field generated during MR imaging and dependent on candidate data models for different object parameter values. A model-based candidate data stimulation is selected as a stimulation model for the patient dependent on an individual patient model. A distribution of a vector potential of a gradient magnetic field acting on the patient is determined as a function of a unit gradient current for a determined position of the patient in the MR scanning unit. The nerve stimulation of the patient is determined for the determined position based on the selected candidate stimulation and a gradient current of a gradient pulse of the MR pulse sequence.

A nerve stimulation system including a stimulation probe including a handle and a stimulation head at an end of the handle; a reference electrode; and a control system in communication with the stimulation probe and the reference electrode, the control system configured to generate an electrical stimulation signal that, when delivered to a skin surface of a patient using the stimulation probe, induces an activation potential in a plurality of nociceptors while remaining below a threshold that induces a muscle contractile response.

A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

Systems and methods for enhancing diagnostic evoked potential recordings of a nerve or nerve pathway of interest. A grid array of stimulating electrodes are placed on, over, or through skin in a location beneath which a nerve or nerve pathway is suspected to lie. A stimulator controls the grid array, where each electrode is independently controllable as active or inactive, as a cathode or anode, etc. A plurality of recording electrodes may record Somato-Sensory Evoked Potentials (SSEPs) and/or Transcranial Electrical Motor Evoked Potentials (TCeMEP) in response to activation of the stimulating electrodes. A processor controls stimulating the stimulating electrodes, and receives responses from the recording electrodes, in a general search mode and a focused search mode in order to use a minimum stimulation intensity at which a maximum response amplitude is detected to continually stimulate the nerve or the nerve pathway.

Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.