Systems and methods for treating a fibrous mass associated with a condition such as Morton's neuroma, plantar firbroma, or Achilles tendinopathy are disclosed. According to illustrative implementations, exemplary methods may comprise identifying a location of the fibrous mass and non-surgically delivering electromagnetic energy to the fibrous mass.

Processes, scales, and devices to measure and quantify wetness perception in humans. Exemplary devices and scales utilize sensor fusion of temperature and pressure modalities, for which humans have dedicated receptors in the skin, to understand how the perception of wetness comes about. Processes test the utility of wetness perception as a biomarker for assaying peripheral neuropathy. Wetness perception devices include a Peltier module. The temperature of the Peltier module can be varied precisely using a computer-aided feedback system, mounted on a load scale to enable concomitant pressure measurements. Devices may include an insulation chamber with desiccators in place to lower internal humidity and prevent condensation. Wetness perception can be used as a non-invasive biomarker for disease-related peripheral neuropathy in which sensory mechanisms are disrupted.

In one embodiment, a system for neurologic vibratory sense evaluation includes a vibration article configured to attach to a body part of a patient under evaluation, the vibration article comprising a vibration element configured to vibrate against the body part, a control module configured to control an amplitude of vibrations generated by the vibration element, and a patient input device configured to enable a patient to start and stop an evaluation session, wherein starting the session in a first mode of operation causes the vibration element to initially vibrate at a relatively high amplitude that gradually decreases and wherein starting the session in a second mode of operation causes the vibration element to initially vibrate at a relatively low amplitude that gradually increases.

The present disclosure describes systems and methods to evaluate auditory efferent function by exposing a patient to short-duration acoustic click stimuli to generate a click-evoked otoacoustic emission (CEOAE) occurring in each ear of the patient, and in response to exposing the patient to click stimuli, concurrently sampling outer hair cell activity (OHC) and medial olivocochlear reflex (MOCR; efferents) in each ear of the patient, monitoring the middle ear muscle reflex (MEMR) in each ear of the patient, and measuring a change in cochlear activity in the patient based on the CEOAE, MOCR, and MEMR of each ear of the patient.

A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.

At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. An electrode is implanted in a muscle of each pair and electrically connected to a motor controller of the device, thereby simulating proprioceptive sensory feedback from the device.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.

An apparatus, system and technique selectively eliminates the noxious signal components in a neuronal signal by creating an interfering electrical signal that is tuned to a given frequency corresponding to the oscillatory pattern of the noxious signal, resulting in a modified neuronal signal that substantially reproduces a normal, no-pain neuronal signal. The disclosed system and technique of pain relief is based on the hypothesis that the temporal profile of pain signals encodes particular components that oscillate at unique and quantifiable frequencies, which are responsible for pain processing in the brain.

A method for treating a fibrous mass associated with a condition such as Morton's neuroma, plantar fibroma, or Achilles tendinopathy. The method comprises identifying a location of the fibrous mass and non-surgically delivering electromagnetic energy to the fibrous mass.