Disclosed are appendage mountable electronic systems and related methods for covering and conforming to an appendage surface. A flexible or stretchable substrate has an inner surface for receiving an appendage, including an appendage having a curved surface, and an opposed outer surface that is accessible to external surfaces. A stretchable or flexible electronic device is supported by the substrate inner and/or outer surface, depending on the application of interest. The electronic device in combination with the substrate provides a net bending stiffness to facilitate conformal contact between the inner surface and a surface of the appendage provided within the enclosure. In an aspect, the system is capable of surface flipping without adversely impacting electronic device functionality, such as electronic devices comprising arrays of sensors, actuators, or both sensors and actuators.

A device applies standardized central and peripheral stimuli to a patient for assessment of consciousness. The device is hand-held and includes a first stimulus element for application of peripheral stimuli to a digit (e.g., a finger or a toe) of the patient and a second stimulus element for application of central stimuli to the patient, enabling practitioners to rapidly switch between peripheral and central stimulus application. The device can generate a standardized electrical stimulus, thermal stimulus, and/or mechanical stimulus for application for improved accuracy when assessing consciousness of the patient by methods such as the Glasgow Coma Scale. In another aspect, the device applies standardized stimuli at an appropriate intensity to elicit a response without causing tissue damage.

Systems and methods for the diagnosis of chronic pain are disclosed. An algometer comprising a pressure sensor and electrode is disclosed. The algometer may be used to measure pressure applied by a clinician at a location on a patient's body, along with EMG signals emanating from the same location of the patient. Further, a pain trigger operable by the patient may be used in coordination with the algometer. Data from the algometer and pain trigger are transmitted to a computing device and display for rendering and analysis of patient data, leading to improved diagnosis.

In general, the invention provides kits, devices, and methods for determining the ineffectiveness of an anesthetic, (e.g., lidocaine), using a topical approach that avoids injection. The methods typically employ the placement of aliquots of two different formulations, at least one including an anesthetic, in different locations on a subject. Further embodiments may employ a single formulation including the anesthetic.

Disclosed are appendage mountable electronic systems and related methods for covering and conforming to an appendage surface. A flexible or stretchable substrate has an inner surface for receiving an appendage, including an appendage having a curved surface, and an opposed outer surface that is accessible to external surfaces. A stretchable or flexible electronic device is supported by the substrate inner and/or outer surface, depending on the application of interest. The electronic device in combination with the substrate provides a net bending stiffness to facilitate conformal contact between the inner surface and a surface of the appendage provided within the enclosure. In an aspect, the system is capable of surface flipping without adversely impacting electronic device functionality, such as electronic devices comprising arrays of sensors, actuators, or both sensors and actuators.

The present invention relates to a radiofrequency (RF) hyperthermia device for personalized treatment and diagnosis using capacitive coupling and without dipole antenna comprising a radiofrequency source, an amplifier, a sensor and a modulation signal input/generator, wherein the radiofrequency source produces a source signal which is modulated by the modulation signal input/generator using the phase information generated by homeostasis of the target to generate a modulated source signal, the modulated source signal is amplified by the amplifier and directed to a target, and the sensor detects the phase information generated by homeostasis of the target to provide a feedback signal, wherein the feedback signal modulates the source signal to generate a personalized modulated signal. This radiofrequency (RF) hyperthermia device is designed for personalized treatment and diagnosis of a target such as a patient or a malignant or tumorous area within a patient.

A novel method of predicting life expectancy in persons, in particular in persons that have an a priori reduced life expectancy, for instance if they suffer from ischemic heart disease (IHD). IHD-related depression, ANSD, type 2 diabetes mellitus is provided. Also disclosed is a related method for increasing life expectancy in human subjects, in particular in human subjects having an a priori reduced life expectancy. The disclosure also provides a method for evaluating the efficacy of drugs other treatment of ANSD. The present invention also provides a novel method for diagnosing and treating/preventing type 2 diabetes mellitus or IHD-related depression. Finally, the disclosure also provides a method for diagnosing autonomic homeostatic glucose dysregulation, and a novel method to re-establish normal homeostatic function, if disrupted, dysregulated or insufficient.

An ongoing pain detection system and method are provided. The method includes obtaining imaging data from patient using functional near-infrared spectroscopy from at least one cortical region of the brain of a non-responsive patient and observing power spectral density variations in the signal. The measured imaging data is compared with patient pain based on control data to recognize ongoing pain in the non-responsive patient.

Disclosed are appendage mountable electronic systems and related methods for covering and conforming to an appendage surface. A flexible or stretchable substrate has an inner surface for receiving an appendage, including an appendage having a curved surface, and an opposed outer surface that is accessible to external surfaces. A stretchable or flexible electronic device is supported by the substrate inner and/or outer surface, depending on the application of interest. The electronic device in combination with the substrate provides a net bending stiffness to facilitate conformal contact between the inner surface and a surface of the appendage provided within the enclosure. In an aspect, the system is capable of surface flipping without adversely impacting electronic device functionality, such as electronic devices comprising arrays of sensors, actuators, or both sensors and actuators.

An object of the present invention is to provide a system for performing objective examination of central sensitization, in particular, a system for objectively determining the presence or absence of central sensitization in a chronic pain patient. The present invention provides a device for diagnosing the presence or absence of central sensitization, the device including: stimulation output means for outputting thermal stimulation which can be perceived by a subject; first input means capable of inputting a measurement start signal; second input means capable of inputting a measurement end signal; and measurement control means for measuring time between an input signal from the first input means and an input signal from the second input means. The measurement control means determines that the central sensitization is present when the time between the input signal from the first input means and the input signal from the second input means is longer than t seconds (where t represents 30 seconds or more and less than 90 seconds).