Disclosed are a microneedle patch, a realtime blood sugar monitoring device, and a realtime blood sugar monitoring method using the realtime blood sugar monitoring device. The realtime blood sugar monitoring device causes a different color to be reversibly expressed according to the concentration of sugar included in the skin of a human body, and, thus, if the device is utilized, the concentration of the sugar in the human body can be measured in realtime in a minimally invasive manner. Also, the present invention shows the measured concentration of the sugar by connecting to a wearable device and, thereby, allows a user to more conveniently check changes in the concentration of the sugar in realtime.

Biological detection apparatuses, systems and methods are provided. A biological detection apparatus may include a flexible substrate and a biosensor. The biosensor is provided on the flexible substrate and configured to obtain substance information of a living body.

Apparatus, methods, and systems for detecting alcohol concentrations of an individual, such as an in vivo alcohol concentrations of an individual. The blood alcohol concentration can be determined based on the peak signal width of the signal received from an analyte sensor.

Apparatus, methods, and systems for detecting alcohol concentrations of an individual, such as an in vivo alcohol concentrations of an individual. The system can include an analyte sensor and a reader. The reader can receive a signal from the analyte sensor. The reader can determine blood alcohol concentration, in part, based on the received signal from the analyte sensor. The reader can also detect an adverse condition of the analyte sensor, and/or output an indication based on the detected adverse condition.

The present disclosure relates to a body attachment device for continuous glucose monitoring and, more particularly, to a body attachment device for continuous glucose monitoring characterized in that as a user command for applying operating power of the body attachment device is inputted by an optical method or a touch method, operation of the body attachment device can be controlled by easily initiating application of battery power not only before the body attachment device is attached to the body but also after the body attachment device has been attached to the body. In addition, as the operation of the body attachment device is controlled by light or touch, it is possible to prevent erroneous operation of the body attachment device that occurs when a user touches, by mistake, a physical operation button formed in the body attachment device while using the body attachment device. Furthermore, the operating power can be stably provided.

The invention relates to a microneedle array and to the use thereof for intradermal delivery, comprising a plurality of microneedles on a carrier, wherein this microneedle array is suitable for penetrating the skin of humans or animals and includes at least one color change indicator.

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Microneedles for analysis of analytes in body fluids may be manufactured from robust materials such as stainless steel by laser cutting at least the basic needle configuration, applying a coating to electrically insulate and/or assure biocompatibility of the needle, and forming electrodes on the needles via lithography or other processes (preferably after treatment of the coated areas at which the electrodes are to be applied). Preferably, the needles have a depression formed therein from which the electrodes extend, and which contains a sensing medium which produces a measurable output in response to the local concentration of the analyte of interest. Thus, when a needle is inserted into the skin such that the depression and its sensing medium encounters body fluids, analyte measurements can be obtained via the electrodes.

A wearable sensor patch including a generally cylindrical base having a bore, and a skin contact surface having an adhesive thereon; a piston-like part positioned within the bore; at least one microprobe positioned on the piston-like part; a retention spring; wherein the piston-like part is movable within the bore of the base between (1) a first position in which the at least one microprobe is positioned within the bore, and (2) a second position in which the at least one microprobe protrudes past the skin contact surface, and wherein the retention spring and the piston-like part are configured to cooperate such that the retention spring retains the piston-like part in either the first position or the second position