The present invention relates to an optical fiber sensor for shape sensing, comprising an optical fiber having embedded therein a number of at least four fiber cores (1 to 6) arranged at a distance from a longitudinal center axis (0) of the optical fiber, the number of fiber cores (1 to 6) including a first subset of at least two fiber cores (1, 3, 5) and a second subset of at least two fiber cores (2, 4, 6), the fiber cores (2, 4, 6) of the second subset being arranged to provide a redundancy in a shape sensing measurement of the fiber sensor (12′). The fiber cores (1, 3, 5) of the first subset are distributed in azimuthal direction around the center axis (0) with respect to one another, and each fiber core (2) of the second subset is arranged in non-equidistantly fashion in azimuthal direction around the center axis (0) with respect to two neighboring fiber cores (1, 3) of the first subset.

A supporting apparatus for supporting insertion of a flexible insertion member into a subject and removal of the insertion member includes a position acquisition unit, an interrelation calculation unit and a determination unit. The position acquisition unit acquires information on displacements at at least two attention points located at positions that are different in the longitudinal direction of the insertion member. The interrelation calculation unit calculates a degree of interrelation of the displacements acquired at the at least two attention points. The determination unit determines a state of the insertion member or a state of a predetermined target portion of the subject, based on the degree of interrelation.

A supporting apparatus for supporting insertion of a flexible insertion member into a subject and removal of the insertion member includes a self-following property evaluation unit and a determination unit. The self-following property evaluation unit evaluates self-following property or lateral movement during insertion of the insertion member. The determination unit which determines a state of the insertion member or the subject, based on the self-following property or the lateral movement.

A supporting apparatus for supporting insertion of a flexible insertion member into a subject and removal of the insertion member includes a tangential direction acquisition unit, a moving direction acquisition unit and a determination unit. The tangential direction acquisition unit acquires a tangential direction at at least one point of a predetermined portion in a longitudinal direction of the insertion member, based on a shape of the insertion member. The moving direction acquisition unit acquires a moving direction of the point. The determination unit determines states of the insertion member and the subject, based on the tangential direction and the moving direction.

Described herein are methods and systems for calculating a corrected Fractional Flow Reserve (FFR). An illustrative method includes delivering a first pressure sensing device including a pressure sensor to a location in a blood vessel having a stenosis, positioning the pressure sensor distal to the stenosis, measuring the distal pressure, measuring the proximal pressure, and calculating a corrected FFR using the measured proximal and distal pressures and applying a correction factor or correction equation. The corrected FFR may approximate a FFR that would have been obtained if the pressure measured downstream of the stenosis was measured using a second pressure sensing device having a second maximum cross-sectional area in a distal portion of the second pressure sensing device that is different from the first maximum cross-sectional area.

Medical devices and methods for making and using medical devices are disclosed. An example method may include a method for calculating fractional flow reserve including providing a pressure sensing guidewire, advancing the pressure sensing guidewire through a blood vessel to a first position distal of an intravascular occlusion, determining a distal pressure within the body lumen with the pressure sensing guidewire, proximally shifting the pressure sensing guidewire to a second position proximal of the occlusion, determining a proximal pressure within the body lumen with the pressure sensing guidewire, measuring an aortic pressure, and calculating a pressure drift. The pressure drift may be the difference between the aortic pressure and the proximal pressure. The method may also include calculating a drift-compensated fractional flow reserve. The drift-compensated fraction flow reserve may correspond to (the distal pressure+the pressure drift) divided by the aortic pressure.

A guidewire with a cross section of at least a part of its length, comprising a filling material (PLM), a lumen (LM) arranged inside the filling material (PLM) for accommodating an optical fiber (OF) with optical shape sensing properties. One or more stiffening elements (RD) are arranged inside the first material (PLM), wherein the stiffening element(s) (RD) is formed by a material having a higher axial stiffness than the filling material. A braiding structure (BR) encircles all of: the filling material (PLM), the lumen (LM), and the stiffening element(s) (RD). Such guidewire can be designed with a circular symmetric bending behavior, and is thus suitable as an interventional medical device, e.g. for endovascular procedures, and still it can provide optical shape sensing properties.

A guidewire manipulation system may include a cylindrical drum, having a cylindrical outer drum surface with a helical groove for housing a flexible guidewire and an anchoring mechanism for attaching the flexible guidewire to the drum. The system may also include an outer shell or belt disposed around the drum, forming an opening through which the flexible guidewire exits. The system may also include a first actuator coupled with the drum for rotating the drum about a first axis, and a second actuator coupled with the drum for rotating the system about a second axis.

A system and method are presented for detecting and measuring pressure within a region of a body lumen or vessel. The pressure sensing system includes a light source for transmitting light through a pathway of polarization maintaining fiber optic wire. A distal portion of the polarization maintaining fiber optic wire is engaged to and extends along a guidewire. The distal portion of the fiber optic wire includes pressure sensing station(s) made up of fiber Bragg gratings (FBG). The light transmitted to and reflected from the FBGs on the two polarization modes of the polarization maintaining fiber optic wire can be analyzed to provide one or more pressure values.

Medical devices including optical connector cable assemblies are disclosed. An optical connector cable assembly may include an optical connector cable having a first optical fiber extending therefrom. The optical connector cable may include a distal connector configured to connect to a guidewire. The distal connector may include an inner housing and a guidewire locking mechanism. The distal connector may also include an actuator. Actuation of the actuator may move the inner housing from a first position to a second position. When the inner housing is in the first position the guidewire locking mechanism is configured to secure the guidewire and the guidewire is rotatable with respect to the optical connector cable. When the inner housing is in the second position the guidewire locking mechanism is in an open state for receiving or removing the guidewire.