Techniques for providing therapy to a patient via electrical stimulation are described. The techniques include, for example, determining, relative to a start time of providing the electrical stimulation, one or more efficacy times that correspond to an efficacy indicator, determining, according to the efficacy times, efficacy data items for the patient, comparing the efficacy data items with the efficacy indicator, and generating, based on the comparison, a prediction of an expected response to the therapy manifesting in the patient at a prospective time.

Methods and arrangements are described for developing a virtual channel matrix for mapping analysis channels to stimulation channels for a cochlear implant patient by selecting a stimulation channel and measuring the amplitude growth function for the selected stimulation channel in response to commands to the cochlear implant to apply electrical stimulation pulses for the stimulation channel, where each stimulation pulse comprises a negative and a positive phase separated in time by a first inter-phase-gap; and measuring the amplitude growth function for the selected stimulation channel in response to commands to the cochlear implant to apply electrical stimulation pulses for the stimulation channel, where each stimulation pulse comprises a negative and positive phase separated in time by a second inter-phase-gap and whereby the first and second inter-phase-gaps are different. Thereafter Determining the slopes of the measured amplitude growth functions for the stimulation channel measured with the first and second inter-phase-gaps, and calculating an indicator based at least in part on the difference of the slopes of the amplitude growth functions indicative of the local neural survival for that stimulation channel. Thereafter Repeating this process for each stimulation channel where an indicator shall be derived and selecting for the virtual channel matrix the stimulation channels with best local neural survival by optimizing a function based at least in part on the calculated indicators of the stimulation channels.

Described herein are methods, devices and system for determining whether an R-wave detection should be classified as a false R-wave detection due to T-wave oversensing (TWO) or P-wave oversensing (PWO). One such method includes comparing a specific morphological characteristic (e.g., peak amplitude) associated with the R-wave detection to the specific morphological characteristic associated with each R-wave detection in a first set of earlier detected R-wave detections to thereby determine whether first TWO or PWO morphological criteria are met, and in a second set of earlier detected R-wave detections to thereby determine whether second TWO or PWO morphological criteria are met, wherein the second set differs from the first set but may have some overlap with the first set. The method also includes determining whether to classify the R-wave detection as a false R-wave detection, based on whether one of the first or second TWO or PWO morphological criteria are met.

A medical having a motion sensor is configured to set an atrial event sensing parameter used for sensing atrial event signals from a motion signal produced by the motion sensor. The medical device sets an atrial event sensing parameter by applying a sensing window during each one of multiple ventricular cycles, determining a feature of the motion signal during the sensing window for at least a portion of the ventricular cycles, and setting the atrial event sensing parameter based on the determined features. The medical device may sense the atrial event from the motion signal according to the atrial event sensing parameter.

Systems and method for monitoring the blood glucose concentration of a patient during a hemodialysis session and automated administration of a medication in response to the glucose concentration falling outside a specified range. The system includes a hemodialysis system and a glucose sensor. The hemodialysis system includes a control system, at least one medication infusion pump, and a dialyzer fluidly connectable to a venous patient line and an arterial patient line. The glucose sensor is in communication with the control system and positioned to continuously measure the blood glucose concentration of the patient during the hemodialysis session. The control system can be programmed to provide automated administration of medication by the at least one medication infusion pump in response to changes in the blood glucose concentration of the patent during the hemodialysis session.

A system comprising a plurality of electrodes adapted to measure bio impedance measurements using electrical currents passing in a target thorax area of a target therebetween during a learning phase, at least one radiofrequency (RF) sensor adapted to measure RF interaction measurements of RF radiation interacting with the target thorax area during the learning phase, and at least one processor adapted to: calculate calibration function according to the bio impedance measurements and the RF interaction measurements, and determine a target thorax area value by adjusting subsequent bio impedance measurements using subsequent electrical currents passing in the target thorax area during an operational learning phase using the calibration function.

Methods and systems for use of the Q-wave to R-wave interval to guide placement of a leadless cardiac pacemaker are disclosed. An implant delivery device is equipped with sensing electrodes to sense R-wave onset in a ventricle of a patient's heart to allow placement at a location of last or latest onset of the R-wave. Guidance tools are provided to assist in determination of the Q-wave to R-wave interval during implantation. For a chronic system, a cooperative approach is disclosed in which an implantable medical device and a leadless cardiac pacemaker exchange data to determine Q-wave to R-wave intervals and enhance cardiac resynchronization therapy delivery by the leadless cardiac pacemaker.

A bridge device includes a housing, a plurality of electrodes exposed outside of the housing such that at least two of the plurality of electrodes can be concurrently placed in contact with a patient's skin. A controller is disposed within the housing. A first communications module is operably coupled to the controller and to the at least two of the plurality of electrodes. The first communications module is configured to allow the controller to communicate with an implantable medical device via at least two of the plurality of electrodes using conducted communication. A second communications module is operably coupled to the controller and is configured to allow the controller to communicate with a remote device external to the patient.

A medical device including a hybrid circuitry assembly, a core assembly housing having an inside surface, and a tag/getter assembly. The core assembly housing to enclose the hybrid circuitry assembly, and the tag/getter assembly to be situated adjacent the inside surface of the core assembly housing. The tag/getter assembly including an identification tag and a hydrogen getter.

A leadless pacemaker device configured to provide for an intra-cardiac pacing, including: processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity, and a reception device for receiving a sensing signal indicative of an atrial activity, wherein the processing circuitry is configured to detect an atrial event derived from said sensing signal, wherein the atrial event is a valid atrial sense event, where a series of atrial events lie within a range for a normal atrial rate, and/or when the atrial rate variability is within a certain range indicating a regular atrial rhythm, wherein in case a valid atrial sense event is detected, the processing circuitry is further configured to: determine ventricular pacing events according to atrial events, calculate ventricular-atrial time delays, determine a correction value based a measured time delay and the calculated time delay, and adjust the ventricular pacing timing based on the correction value.