It is recognized that, because of its unique properties, graphene can serve as an interface with biological cells that communicate by an electrical impulse, or action potential. Responding to a sensed signal can be accomplished by coupling a graphene sensor to a low power digital electronic switch that is activatable by the sensed low power electrical signals. It is further recognized that low power devices such as tunneling diodes and TFETs are suitable for use in such biological applications in conjunction with graphene sensors. While tunneling diodes can be used in diagnostic applications, TFETs, which are three-terminal devices, further permit controlling the voltage on one cell according to signals received by other cells. Thus, by the use of a biological sensor system that includes graphene nanowire sensors coupled to a TFET, charge can be redistributed among different biological cells, potentially with therapeutic effects.

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

A sensor insertion device includes a first elastic member; a second elastic member; an elastic energy variable mechanism configured to elastically deform the first elastic member and the second elastic member to achieve an energy accumulated state; a first holding mechanism configured to hold a position of the first elastic member in the energy accumulated state; and a second holding mechanism configured to hold a position of the second elastic member in the energy accumulated state for a period of time during which, after the release of the first elastic member from the first holding mechanism in the energy accumulated state, the needle member is moved to the insertion position by the first elastic energy.

Devices, systems, and methods for remotely monitoring physiologic cardiovascular data are disclosed. At least some of the embodiments disclosed herein provide access to the external surface of the heart through the pericardial space for the delivery of the sensor to the epicardial surface of the heart. In addition, various disclosed embodiments provide for a memory device capable of receiving the physiologic cardiovascular data collected by the sensors and transmitting such data wirelessly to a remote location.

The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

An insertion device is an insertion device configured to insert a medical device into a living body, including a needle portion to which at least a portion of the medical device is adhered and being inserted into the living body together with the adhered medical device; and a movable portion configured to be movable relatively to the needle portion in a direction of insertion of the needle portion, wherein the movable portion moves relatively to the needle portion in the direction of insertion to cut an adhered region between the medical device and the needle portion and separate the medical device and the needle portion.

It is recognized that, because of its unique properties, graphene can serve as an interface with biological cells that communicate by an electrical impulse, or action potential. Responding to a sensed signal can be accomplished by coupling a graphene sensor to a low power digital electronic switch that is activatable by the sensed low power electrical signals. It is further recognized that low power devices such as tunneling diodes and TFETs are suitable for use in such biological applications in conjunction with graphene sensors. While tunneling diodes can be used in diagnostic applications, TFETs, which are three-terminal devices, further permit controlling the voltage on one cell according to signals received by other cells. Thus, by the use of a biological sensor system that includes graphene nanowire sensors coupled to a TFET, charge can be redistributed among different biological cells, potentially with therapeutic effects.

A method of obtaining symmetric temperature change, comprising the following steps of preparing a temperature sensing device; measuring and collecting temperature change: placing the temperature sensing device (1) on a predetermined position of a participant to measure and collect the participant's body temperature change data; extracting data; removing the temperature sensing device from the participant's body when running out of the battery and then connecting a reading device to extract the body temperature change data out of the temperature sensing device in order to apply the body temperature change data in precision medicine; the body temperature change data is used as the key marker without affecting the participant's daily activity, preventing the participant from inaccuracy of the body temperature change data caused by psychological and/or physiological factors, so the body temperature change data can be applied in the symmetry precision medicine.

A metabolic physical activity monitor measures metabolic analyte data using one or more wearable analyte sensors. The sensors may be incorporated into a self-contained device or communicatively coupled to an external computing device like a smartphone or computer or both. Sensors may be mounted on any body surface including the skin, under the eyelid or in the mouth. Metabolic Analyte biomarker data may include electrolytes, various metabolites, pCO2 and pO2 in sweat, saliva and tears. Sensor data are used to calculate specific biomarker values, including calorie expenditure. Sensor readings are taken for at least two points during a period of physical activity. Changes in readings are used to determine total and rate of caloric expenditure for the time period. Readings may also be used to evaluate a user's wellness. By using measured changes in relative values complex calibration procedures can be eliminated, while reproducibility is much more easily achieved.