An intraosseous needle set is provided for penetrating a target area. The intraosseous needle set includes a cannula having a first end, a second end, and a bore. The bore may accommodate an intraosseous device, such that the intraosseous device and the cannula are operable to penetrate the target area. The bore has a length extending from the second end of the cannula through the first end of the cannula. The bore has a first cross-section with a substantially constant diameter along a majority of the length and extends from the second end of the cannula toward the first end of the cannula. The bore has a second cross-section along a minority of the length and extends from the first end of the cannula toward the second end of the cannula. The second cross-section may have a different shape than the first cross-section.

An instrument for collecting tissue from a body cavity includes a hollow tubular body having a tubular wall. The hollow tubular body can collect material from a body cavity in a coring mode or an aspiration mode. The tubular wall defines a passage that extends from a proximal end portion of the tubular body to a distal end portion of the tubular body. A middle section of the tubular body includes an articulating section that allows the middle section to articulate relative to the proximal end portion. The distal end portion includes at least one suction port extending from an outer wall surface to an inner wall surface of the tubular wall. The suction port provides a path of fluid communication between the outer wall surface and the passage for drawing in tissue from a body cavity when the tubular body is connected to a source of negative pressure.

An instrument for collecting tissue from a body cavity includes a hollow tubular body having a tubular wall. The hollow tubular body can collect material from a body cavity in a coring mode or an aspiration mode. The tubular wall defines a passage that extends from a proximal end portion of the tubular body to a distal end portion of the tubular body. A middle section of the tubular body includes an articulating section that allows the middle section to articulate relative to the proximal end portion. The distal end portion includes at least one suction port extending from an outer wall surface to an inner wall surface of the tubular wall. The suction port provides a path of fluid communication between the outer wall surface and the passage for drawing in tissue from a body cavity when the tubular body is connected to a source of negative pressure.

Apparatuses, systems, and methods are provided for securing an intra-osseous device within a safety device to prevent stick injuries and to guide the removal of the intra-osseous device from the bone of a patient. A body of the safety device has a cavity that receives the intra-osseous device, and the cavity guides the removal of the intra-osseous device along a straight line to prevent injury during removal. The intra-osseous device is drawn past a lock feature that secures the intra-osseous device within the body such that a needle of the intra-osseous device is contained within a cavity of the body and cannot injure the patient, staff members, etc.

A disposable device used for an intraosseous infusion is provided. The intraosseous infusion device includes a driver including a motor and a power unit and an internal trocar manufactured to be integral with the driver. An intraosseous infusion procedure is performed in a sterile way since the internal trocar is integrated with the driver in the intraosseous infusion device.

A coupler (2) for the sterile coupling of a percutaneous surgical instrument to a rotational-driving tool (3), extending along a coupling axis (A). The coupler (2) has a distal portion (27) configured to be connected removably to a percutaneous surgical instrument, a proximal portion (28) configured to be connected removably to a driving tool (3), a central portion (29) arranged between the distal (27) and proximal (28) portions. The central portion has a bearing collar (240) extending transversely to the coupling axis (A) and configured to axially deform a distal end of a flexible wrapper (1) surrounding the driving tool (3) when the proximal portion (28) is connected to this driving tool (3)/ The central portion also has a retaining collar (243) extending along the coupling axis (A) at least partially covering the proximal portion (28) so as to be able to keep the distal end of the sterile flexible wrapper (1) between the retaining collar (243) and the housing (36) of a driving tool (3) when the proximal portion (28) is connected to the driving tool (3).

An apparatus for penetrating bone and accessing bone marrow is provided. The apparatus may include a penetrator assembly and a powered drill to penetrate the bone into the bone marrow. The penetrator assembly may include a trocar having a stylet. The penetrator assembly may also include an outer penetrator having a hollow cannula and a luer lock attachment. The powered drill may include a housing enclosing a motor and a power supply and associated circuitry. The powered drill may also include a connector receptacle for receiving a penetrator assembly connector of the penetrator assembly. The connector receptacle may releasably lock the penetrator assembly connector into place with the powered drill. The power supply may include a rechargeable battery within the housing for supplying power to the motor. A battery indicator may be provided to indicate a level of the battery.

A bone marrow aspiration device and related method includes an introducer assembly and an aspiration assembly to couple to the introducer assembly. The introducer assembly includes an introducer cannula having a proximal end and a distal end. The introducer cannula defines a lumen between the distal and proximal ends, the distal end being configured to penetrate bone of a patient. The aspiration assembly includes an aspiration cannula that is receivable in the lumen of the introducer cannula and that extends beyond the distal end of the introducer cannula. The aspiration cannula includes a port to aspirate bone marrow, the port being distal to the distal end of the introducer cannula. The aspiration device further includes a mechanism at the introducer assembly to move the introducer cannula and the aspiration cannula in tandem relative to a distal end of the mechanism when the aspiration cannula is positioned within bone.

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.

A device and method for aspirating bone barrow. The device includes a double syringe assembly having a distal syringe and a proximal syringe coupled to the distal syringe. A plunger includes a distal end disposed within a barrel of the distal syringe and a proximal end disposed within a barrel of the proximal syringe. A needle assembly is coupled to the double syringe assembly and includes a needle having an outer tube and an inner tube disposed within the outer tube. Upon actuation of the plunger, the distal syringe aspirates bone marrow through the outer tube of the needle and into a chamber of the distal syringe. At the same time, the proximal syringe injects fluid through the inner tube of the needle at the same rate in which the bone marrow is aspirated.