A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

A vibrating tissue separator suitable for use in separating a lenticule established by a femtosecond laser during a smile procedure may include a surgical implement such as a blunt spatula mounted on a handle that carries a haptic actuator for applying vibratory motion to the surgical implement. A damping arrangement may be provided to isolate the surgeons hand from the vibrations which would otherwise be transmitted through the handle. The actuator may apply a linear vibration along the axis of the handle which applies a lifting and chopping motion to the tip of a surgical implement having a bend. The tip may be suitable to the tissue being separated. For example, for SMILE lenticule separation, a blunt or semi-sharp spatula, blunted wire or loop may be used. The direction of vibration at the tip may be changed by rotating the implement in a plane other than the plane of the bend or by rotating an actuator such as an LRA with respect to the handle.

The present invention relates to an apparatus for cutting-out including a device for treating a L.A.S.E.R. beam generated by a femtosecond laser (1), and positioned downstream from said femtosecond laser, the treatment device comprising: a shaping system (3) positioned on the trajectory of said beam, for modulating the phase of the wave front of the L.A.S.E.R. beam according to a modulation set value calculated for distributing the energy of the L.A.S.E.R. beam in at least two impact points forming a pattern in its focal plane, an optical focusing system (5) downstream from the shaping system, the optical focusing system comprising a concentrator module for focusing the phase-modulated L.A.S.E.R. beam in a focusing plane and a depth-positioning module for displacing the focusing plane into a plurality of cutting-out planes, a sweeping optical scanner (4) positioned between the concentrator module and the depth-positioning module for displacing the pattern in the cutting-out plane in a plurality of positions.

The invention relates to a device for measuring an optical penetration that is triggered in a tissue underneath the tissue surface by means of therapeutic laser radiation which a laser-surgical device concentrates in a treatment focus located in said tissue. The inventive device is provided with a detection beam path comprising a lens system which couples radiation emanating from the tissue underneath the tissue surface into the detection beam path. A detector device generating a detection signal which indicates the spatial dimension and/or position of the optical penetration in the tissue is arranged downstream of the detection beam path.

The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

A device for irradiation of the eye of a living subject with light such as UV light includes a structure (20) adapted to overlie the outer surface of the eye, the structure having an axis (28, 128) extending in a downward direction (D) towards the eye when the structure overlies the eye. A light scattering element (70, 158, 141) within the structure includes a peripheral portion remote from the axis and a central portion adjacent the axis. A plurality of transmission optical fibers (42, 157) in optical communication with the peripheral portion of the light scattering element at a plurality of locations spaced around the axis.

A focusing optical system for a UVL-LVC system with a UV laser source and a scanning system that focuses a laser in a focal field and a lens assembly with a convergent focal field. The invention further includes a planning unit that generates planning data for a UVL-LNC system with a UV laser source, a scanning system, a focusing optical system, and a control unit for controlling the UVL-LVC system while taking into consideration planning data, wherein the planning unit takes into consideration geometry losses, Fresnel losses, and/or a spatial extension of laser radiation on a working surface while calculating the planning data, and the planning unit has an interface that provides the planning data. Finally, the invention includes a UVL-LVC system with a UV laser source, a scanning system, a focusing optical system according to the invention, a planning unit according to the invention, and a control unit.

Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incision. In an embodiment, an ophthalmic surgical laser system comprises a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, an XY-scan device to deflect the pulsed laser beam, a Z-scan device to modify a depth of a focus of the pulsed laser beam, and a controller configured to form a top lenticular incision and a bottom lenticular incision of a lens in a corneal stroma.

A method for aligning a system for laser-based ametropia correction relative to a patient's eye to be treated is disclosed. Predefined pre-operative measurement data which characterize at least predetermined structures of the patient's eye is provided. The predetermined structures include a part of the patient's eye to be treated. In addition, the method includes measuring at least one part of the predetermined structures of the patient's eye using an OCT system immediately before and/or during treatment for ametropia correction of the patient's eye and providing OCT measurement data, and comparing the OCT measurement data and the predefined pre-operative measurement data and preparing comparative data. The method also includes ascertaining a position and/or orientation of the part of the patient's eye to be treated relative to the system and aligning the system relative to the patient's eye using the ascertained position and/or orientation of the part of the patient's eye.

A laser instrument for therapy on the human eye, designed for surgery of the cornea, the sclera, the vitreous body or the crystalline lens, especially suitable for use in immediate succession with other instruments for eye diagnosis or eye therapy, in such a way that during the alternating use of the various instruments, the eye or at least the patient preferably remains in a predetermined position and alignment within one and the same treatment area.