The present invention relates to a method and a composition to prevent or treat acne by selective inhibition of P. acnes bacteria. This is delivered using a composition comprising P. acnes phage-derived endolysins where the actives are maintained at conditions like use of non-ionic polymers and specific pH and electrolytes range that ensure maximal inhibition efficacy.

The present invention relates to a single-stranded DNA aptamer that binds to glutathione to inhibit oxidation of the glutathione or stabilize the glutathione, characterized in that the single-stranded DNA aptamer has one or more stem-loop structures; a method for oxidation prevention and stabilization of glutathione using the aptamer; and application to various fields such as pharmaceuticals, cosmetics, and food, using the aptamer. The aptamer of the present invention can be applied to various fields, such as pharmaceuticals, cosmetics, and food, which require oxidation prevention and stabilization of glutathione.

Described herein are UV-resistant or UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing UV-resistant proteins such as, for example, hexokinase, heat shock proteins, alcohol dehydrogenase, transferrin, flavonol synthase, zinc oxidase, and iron oxidase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein.

Skin care compositions and methods are provided. In some embodiments, the skin care compositions include retinol and polydeoxyribonucleotide (PDRN). In certain embodiments, methods of using the aforementioned skin care compositions are provided as treatment for skin aging and/or acne scars.

An application of a transgenic stem cell-derived exosome in preparing a medicament or whitening cosmetic is provided. In the present disclosure, miR-27b-3p is transfected into an epidermal stem cell, and a transgenic stem cell-derived exosome is harvested. It is experimentally verified that the exosome can inhibit the expression of PIK3R3 protein in melanocytes and the proliferation and migration of melanocytes; and safety experiments further demonstrate the safety of the exosome. Therefore, corresponding medicaments or cosmetics prepared from the exosome have excellent medicinal and cosmetic application prospects.

The invention relates to a topical composition comprising an extract of Tiger lily (Lilium tigrinum) enriched in low molecular weight RNA. The invention also relates to a method of cosmetic care including the topical application a composition comprising an extract of Tiger lily (Lilium tigrinum) in a physiologically acceptable medium, in order to reduce skin signs of aging and photo-aging. The invention is also directed to a cosmetic method of treatment to improve cell viability, to improve cell protection against particulate matter and against DNA damages, and to reduce cellular senescence.

The present invention pertains to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.

The invention relates to a composition for slowing cellular ageing which comprises at least: S-Adenosyl-methionine; an extract of at least one adaptogenic plant selected among plants belonging to the Astragalus, Dioscorea, Schisandra, Panax, Eleuterococcus, Rosmarinus, Pfaffia, Morinda, Cordyceps or Lepidium genera; a vitamin selected among the B vitamins, vitamin C, or a mixture thereof; except for compositions comprising 7-keto-DHEA and an extract of one or more adaptogenic plants belonging to the Dioscorea or Lepidium genera. A liquid or solid food supplement can be characterised in that it comprises the composition. A dermatologically acceptable composition can be characterised in that it comprises at least 10 wt % of the composition.

The present invention relates to an acyl-CoA synthetase homolog protein from microorganisms of the genus Mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-CoA synthetase homolog protein gene from, e.g., Mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc.

The present disclosure relates to a method for preventing spontaneous oxidation of an antioxidant, material thereof and uses thereof. More particularly, the present disclosure relates to a method for preventing oxidation of an antioxidant using aptamer specifically binding to its target antioxidant and aptamer-based control of the release rate of active ingredient in the hydrogel. Aptamer having such activity can have versatile applications such as cosmeceuticals and health beverages. As an example, we provide in the present disclosure the establishing method of aptamer targeting for Vitamin C and verification of its prevention of spontaneous oxidation of Vitamin C. We also provide the detailed method for trapping such aptamer-active ingredient complex in the hydrogel. It is expected that an aptamer-trapped hydrogel of the present disclosure has functions of controlling a release rate of the active ingredient through the aptamer-based sensing of specific substance released from the skin according to the skin conditions.