A valved sheath introducer for venous cannulation, including a valve, sheath, handle and cap. The valve is configured to permit safe introduction and removal of medical instruments through the sheath introducer. The valve may have one or more anchoring members and a thickened central portion through which a slit is formed. The central portion may have one or more concave surfaces and the slit can be angled with respect to the top surface of the valve. The cap is attached to the handle, compressing a portion of the valve therebetween.

A slit valve (10) to selectively restrict the passage of a fluent substance between an interior environment (17) and an exterior environment (15) and a method for forming the valve (10), the method including the steps of providing at least one layer of film material and permanently deforming the film material to define a valve (10) for selectively restricting the passage of a fluent substance between an interior environment (17) and an exterior environment (15).

A blood bag system includes a clamp installed in a flexible first tube. The clamp includes: a base section having a protrusion section, an opening/closing section having a pressing protrusion section that presses a side surface of the first tube, and a bent section that connects the base section and opening/closing section. The base section is provided with a pair of cutout sections opened to a side surface where the first tube can be inserted by interposing the protrusion section. The clamp is configured such that a portion of the first tube where the clamp is installed is bent while the clamp is released.

A collapsible valve comprising a first portion with at least one dimple in a side thereof, and a second portion, the second portion being narrower than the first portion and arranged along an axial dimension of the first portion, the second portion including a cut therein.

A method can comprise: positioning a prosthetic heart valve in a collapsed configuration at an implantation site. In some examples, the prosthetic heart valve can comprise: a multi-part frame having a body frame and a leaflet frame, and at least one leaflet coupled to the multi-part frame. In some examples, the prosthetic heart valve can be expandable between the collapsed configuration and an expanded configuration. The method can further comprise expanding the prosthetic heart valve to the expanded configuration at the implantation site, transitioning the multi-part frame of the prosthetic heart valve from a non-everted configuration to an everted configuration, and securing the prosthetic heart valve at the implantation site.

In some implementations, an apparatus includes a body, a receiver in contact with the body, at least one tensioner operable coupled to the receiver, and a strap further comprising a strong and flexible material, each end of the strap operably coupled to one of the at least one tensioner, the strap being in contact with the body.

Disclosures include a method for manufacturing a ball member usable in a flow control valve. The method comprises connecting a workpiece to a rotating apparatus along an axis of rotation of the workpiece, simultaneously rotating the workpiece about the axis of rotation and moving a rotating cutting tool toward the axis of rotation along a second axis to form a first curved surface having a progressively shorter radius with respect to the axis of rotation, wherein the second axis is generally oriented perpendicular to the axis of rotation, and cutting a bore through the workpiece, wherein one end of the bore extends through the first surface and the other end of the bore extends through the second surface.

Nozzle and a method of making the same are disclosed. The method includes forming a material into a nozzle forming microstructured pattern comprising a plurality of nozzle hole forming features and planar control cavity forming features; forming at least one different material into a nozzle pre-form using the nozzle forming microstructured pattern, with the nozzle pre-form comprising a plurality of nozzle pre-form holes and sacrificial planar control cavities; and forming a nozzle from the nozzle pre-form, said forming the nozzle comprising removing enough of the at least one different material to remove the sacrificial planar control cavities so as to form a top surface of the nozzle pre-form into a top surface of the nozzle, and to form each of the nozzle pre-form holes into a nozzle through hole.

A method of assembling a prosthetic heart valve includes providing a collapsible and expandable stent having an annulus section and an aortic section. The annulus section has a first diameter in a relaxed condition and a second diameter less than the first diameter in a collapsed condition. A constraint is applied to the stent to constrain the annulus section to a predetermined diameter between the first and second diameters. Applying a cuff and/or a plurality of leaflets to the stent in the constrained condition enables less material to be used. The resultant prosthetic valve is therefore able to be collapsed to a smaller diameter for introduction into a patient.

Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution including a dispensing accessory with a first valve made of an elastomer material that allows the substance to pass through when the dispensing accessory is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory is relaxed, characterized in that the first valve is covered by a layer of Parylene.