Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

A reversing valve comprising a valve body having an internal cavity therein and an input port, output port and first and second reversing ports. A baffle is located within the internal cavity and is configured to rotate around a pivot point within the internal cavity. At least one electromagnet is coupled to the valve body. The electromagnet is configured to cause the baffle to rotate in one of the clockwise direction or counter-clock wise direction when a voltage is applied to the electromagnet.

In some implementations, an apparatus includes a container having an exterior surface, having an interior surface and having a defect, a gasket positioned over the defect in the container, the gasket having a length, a width and a depth, a rigid patch positioned over the gasket, a plurality of pairs of studs and nuts positioned near the outer perimeter of the rigid patch, the studs being friction welded to the exterior of the container.

A method and apparatus for the singulation of valve plates and/or assembled valves from a lead-frame are described. The method and apparatus utilizes an electric current to fuse tabs which join the valve plate and/or the assembled valve to the lead-frame. The valve comprises a first and second valve plate with offsetting apertures and a flap disposed and movable between the first and second plates.

A blocked end portion of a cylinder is provided closer to a distal end side in a direction of insertion of the piston into the cylinder than a minimum diameter portion. The blocked end portion includes a minimum diameter uniform portion which has the same inside diameter as the minimum diameter portion and a partial diameter increased portion which has an inside diameter that is increased as compared to the inside diameter of the minimum diameter portion.

A method of assembling a prosthetic heart valve includes providing a collapsible and expandable stent having an annulus section and an aortic section. The annulus section has a first diameter in a relaxed condition and a second diameter less than the first diameter in a collapsed condition. A constraint is applied to the stent to constrain the annulus section to a predetermined diameter between the first and second diameters. Applying a cuff and/or a plurality of leaflets to the stent in the constrained condition enables less material to be used. The resultant prosthetic valve is therefore able to be collapsed to a smaller diameter for introduction into a patient.

Nozzle and a method of making the same are disclosed. The method includes (a) providing a microstructured mold pattern defining at least a portion of a mold and comprising a plurality of replica nozzle holes and replica planar control cavities; (b) molding a first material into a nozzle forming microstructured pattern using the microstructured mold pattern, with the nozzle forming microstructured pattern comprising a plurality of nozzle hole forming features and planar control cavity forming features; (c) forming a second material into a nozzle pre-form using the nozzle forming microstructured pattern, with the nozzle pre-form comprising a plurality of nozzle pre-form holes and sacrificial planar control cavities; and (d) forming a nozzle from the nozzle pre-form, said forming the nozzle comprising removing enough of the second material to remove the sacrificial planar control cavities so as to form a top surface of the nozzle pre-form into a planar top surface of the nozzle, and to form each of the nozzle pre-form holes into a nozzle through hole.

Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution, including a dispensing accessory with a first valve made of an elastomer material that allows the substance to pass through when the dispensing accessory is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory is relaxed, characterized in that the first valve is covered by a layer of Parylene.

A reversing valve comprising a valve body having an internal cavity therein and an input port, output port and first and second reversing ports. A baffle is located within the internal cavity and is configured to rotate around a pivot point within the internal cavity. At least one electromagnet is coupled to the valve body. The electromagnet is configured to cause the baffle to rotate in one of the clockwise direction or counter-clock wise direction when a voltage is applied to the electromagnet.

A valve, and tubular cage component for a valve, in which the tubular cage is formed such that at least a ported portion between the ends of the cage includes a tubular outer cage member formed from a metal material, and a tubular inner cage member formed from a wear resistant material. The inner cage member and the outer cage member are concentrically aligned and have a length to span at least the ported portion. Some or all of the flow ports in the ported portion include a port insert which includes a port sleeve formed from a wear resistant material such that the port sleeve extends at least over the metal material of the outer cage member at the flow port.