A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

A device for mixing and dispensing bone material is provided. The device comprises a tubular member having an interior surface configured to receive bone material and a fluid to mix the bone material disposed within the tubular member. The tubular member is flexible and has a proximal opening configured to slidably receive a plunger, and a distal opening configured to dispense a mixed bone material from the interior surface of the tubular member. The plunger is less flexible than the tubular member. Methods of mixing and dispensing bone material are also provided.

A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

The invention regards a device for reconstituting a bioactive agent and forming a flowable paste, the device comprising: a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.

An apparatus includes a housing, an actuator, a lock mechanism, and a medicament container. The lock mechanism selectively engages a portion of the housing such that (1) the lock mechanism is maintained in a substantially fixed position when the housing is in a first orientation and (2) the lock mechanism is removable from the housing when the housing is in a second orientation. The medicament container is moved in a proximal direction when the lock mechanism is removed from the housing to mix a first medicament portion contained within the medicament container with a second medicament portion contained within the medicament container. The actuator can be moved from a first position to a second position when the lock mechanism is removed from the housing to release energy stored within an energy storage member such that the medicament container is moved in a distal direction.

A pre-filled medical delivery assembly assembled and configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient may include a multi-bevel cannula piercing element such as for rotational axial engagement to pierce a seal of the BFS vial.

Systems and methods for dispensing Blow-Fill-Seal (BFS) vials such as pre-filled vials containing a vaccine or other medicament via utilization of an assistive dispensing device to selectively compress the fluid reservoir of the BFS vial is shown and described. The assistive dispensing device includes one or more protrusions to aid in applying compressive force to assist in dispensing the liquid from the vial, and may also include a first dosage setting member and a second dosage setting member, that engage each other to limit movement of the one or more protrusions when the proper compression force has been reached.

The present disclosure relates to a medicament container, configured as a flexible bag. The flexible bag includes a proximal end and a distal end having an outlet port. The flexible bag is configured to increase in length between the proximal end and the distal end when being collapsed.

A cartridge droplet dosage device with a cartridge (1) and an actuation element (2), whereby the cartridge (1) includes a reservoir body (3), a cladding (5) and a plug (6), characterized in that a fluid groove (9) projects from the reservoir body (3) into an inner tube valve area (11), whereby the fluid groove (9) is releasable either by the yielding of a sealing rib (12) and/or by the yielding of a part of the cladding (5).

The present disclosure relates to a container (10) for at least a first injectable medicament (60), the container comprising:an elongated body (11) having a tubular-shaped sidewall (12) extending along a longitudinal axis (z) and having a distal end (13), wherein the elongated body (11) comprises a hollow space (15) with a needle receiving subsection (17) adjacent to the distal end (13),an outlet (40) at the distal end (13) of the body (11),a piston (20) arranged inside the elongated body (11), sealingly engaged with the sidewall (12) and slidable along the longitudinal axis (z) relative to the sidewall (12),a membrane (30) arranged inside the elongated body (11) sealingly engaged with the sidewall (12) and being at least one of slidable and deformable along the longitudinal axis (z) relative to the sidewall (12),a first cavity (16) confined by the sidewall (12), the outlet (40) and the membrane (30), wherein the first injectable medicament (60) is located in the first cavity (16),a second cavity (18) confined by the sidewall (12), the piston (20) and the membrane (30), wherein the piston (20) and the membrane (30) are separated from each other by a distance along the longitudinal axis (z),wherein the outlet (40) is configured to receive or to hold a needle (50) extending from the distal end (13) into the needle receiving subsection (17), andwherein in an initial configuration, the membrane (30) is located outside the needle receiving subsection (17) and wherein the membrane (30) is displaceable or deformable relative to the sidewall (12) to such an extent that at least a portion (31) of the membrane (30) enters the needle receiving subsection (17).