A valve assembly for a drug delivery device includes a valve housing having a first side and a second side positioned opposite from the first side, a cannula having a first end and a second end positioned opposite the first end, a pierce plate having a body and a piercing member extending from the body, with the body defining a coiled elongate member, and a valve boot connected to the valve housing and defining an interior space. The valve boot is configured to move from a pre-use position where the first end of the cannula and the piercing member of the pierce plate are received within the interior space to a use position where the piercing member of the pierce plate and the first end of the cannula extend outside of the valve boot and the interior space.

The passive safety device comprises a sleeve having a proximal end configured to be secured to a distal tip of the injection device, a hub slidably mounted onto the sleeve between a pre-use position, an injection position wherein the hub is proximally located with regard to the pre-use position, and a safety position wherein the hub is distally located with regard to the injection position, a biasing element configured to urge the hub distally towards the safety position, and a protector configured to slide together with the hub relative to the sleeve between the pre-use position and the injection position. The safety device further comprises first blocking means configured to block a distal movement of the protector when the hub is in the injection position so that the protector is prevented from sliding back together with the hub in a distal direction.

A syringe assembly (2) that locks a syringe (10) to prevent backflow of medicament, the syringe assembly (2) comprising a syringe (10) including a barrel (12) configured to carry the medicament, a plunger (14) that communicates with the barrel (12), and a plunger head (16) disposed on a proximal end of the plunger (14), and a locking assembly (50) disposed around the barrel (12), wherein the locking assembly (50) prevents the plunger (14) from moving away from the barrel (12) to draw the medicament into the barrel (12).

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.

A needle-bearing hub for a pen needle is provided with a distal patient-facing side having an enlarged surface for contact with the subject's skin. The enlarged surface is provided with a radius of curvature that increases the likelihood that the needle reaches full injection depth when an injection is performed at an inclined angle with respect to the surface of the skin and with to the desired depth less discomfort to the patient.

Medical device assemblies having a connection mechanism for securely connecting a hub to fluid storage containers in a luer slip relationship are described. An exemplary medical device includes a hub forming a cavity, a second indicating element disposed within the cavity that engages the hub. Additional features of the medical device include a second indicating element contoured to form a line contact with the hub. In a specific configuration, the hub includes a first indicating element attached to the hub and extending proximally into the cavity having a protrusion. In a more specific configuration, the medical device includes a fluid storage container that has an indication system for visually indicating optimal fluid-tight engagement of the hub and the fluid storage container.

The present invention relates to a filtering syringe, and more particularly, to an apparatus obtained by improving a syringe provided with a filter means for filtering foreign substances such as glass fragments of an ampoule, so as to prevent an injection needle or an injection flow passage from being contaminated with the foreign substances while allowing a liquid medicine to be smoothly sucked with a smaller force. The filtering syringe is configured such that the injection needle or the injection flow passage is isolated from the suction flow passage which is upstream of the filter means and in which the foreign substances may remain together with the liquid medicine, thereby allowing the liquid medicine to be sucked with a force less than that required for a conventional syringe and thus maximizing user's convenience and marketability of the syringe.

A system is disclosed for producing a mixture to deliver to a treatment site. The system includes a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be removably connected to a proximal end of the mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to comprise a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The first lumen can terminate in a first port. The second lumen can be configured to include a second constituent. The second lumen can include a second plunger to distally move the second constituent and terminate in a second port. A vial adaptor can be included with a vial having a third constituent.

A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be connected to a proximal end of the mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can receive a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The second lumen can include a second constituent and a second plunger to distally move the second constituent and the first constituent in a second state. Distally moving the second plunger causes the first constituent and the second constituent to be mixed together within the mixing lumen to form the mixture.

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.