A drug delivery assembly includes a housing (110), a piston (120) axially displaceable in the housing, and a variable volume reservoir (105) formed by the housing and the piston and containing a fluid first drug. The assembly further includes an exterior fluid inlet (150) arranged in or configured to be arranged in fluid communication with the reservoir, a fluid outlet (145) arranged in or configured to be arranged in fluid communication with the reservoir, biasing means (130) configured for moving the piston forwards, and releasable retaining means (113) configured for retaining the piston in an initial position, whereby the biasing means is allowed to move the piston forwards to expel fluid drug from the reservoir when the retaining means is released.

In some embodiments, a medical fluid connector is configured to receive an emitter of therapeutic agents to be emitted into a fluid pathway within the connector, the medical fluid connector comprising a proximal female end, an intermediate region, a distal male end, and a fluid pathway extending from the proximal female end, through the intermediate region, to the distal male end. A retaining structure is positioned within the intermediate region. The retaining structure is configured to securely receive an emitter of one or more therapeutic agents in a position and orientation where the fluid pathway is configured to convey fluid moving longitudinally through the fluid pathway directly into a proximal region of the emitter, around one or more lateral surfaces of the emitter, and toward the distal male end.

A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) does not require the user to manually engage a reservoir (22) containing the secondary medicament. Instead, a biasing member (48) automatically activates the reservoir (22) when the needle guard (42) is retracted. The needle guard (42) prevents accidental needle sticks before and after an injection, and locks after dose delivery.

Various embodiments of methods and devices are provided for executing a plurality of injections of a therapeutic agent into an anatomy of a patient diagnosed with Dupuytren's Contracture or Ledderhose's Disease. The plurality of injections are provided by a first therapeutic reservoir comprising a plunger configured to pressure a therapeutic agent held therein into a second, intermediate reservoir or two or more flow channels, through two or more third reservoirs, wherein each of the third reservoirs is in fluid communication with an injection needle. A preferred embodiment comprises a plurality of injection devices comprising injection needles, wherein the injection needles are arranged in a linear array.

A mixing device configured to hold two containers, each having a separate medicament component disposed therein. A fluidic channel is provided that upon creating fluidic communication with each container once seals about each container are opened. Then a transfer mechanism can transfer the medicament components from one container to the other container until ready to be delivered or transferred through the fluidic channel through a delivery assembly.

Techniques, kits and a delivery instrument for providing a material at a defect repair site. The instrument is a combined delivery needle/elevator/paddle that includes a delivery needle and a paddle/elevator tip attached to the end of the needle and around the most distal opening of the needle. The combined needle/elevator/paddle instrument allows both delivery (insertion or injection) of the material/mixture as well as leveling/flattening of the delivered material. The mixture/material may be micronized allograft tissue such as BioCartilage and the surgical site may be a defect site such as a microfracture site or cartilage defect.

An apparatus is presented comprising a lock out member configured to be implemented into a medical device, in particular a dispense interface, attachable to a second medical device, in particular a main body, wherein said lock out member is configured to prevent a second attachment of said medical device to said second medical device, wherein said lock out member has at least a first area with a first cross-sectional area, wherein said lock out member has at least a second area having a second cross-sectional area smaller than the first cross-sectional area, such that an electric resistance is defined between opposite ends of the lockout member and wherein said lock out member, at least in the second area, is made of a conductive material.

In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.

A medicated module attachable to a drug delivery device comprising a connecting body configured for attachment to the drug delivery device. A first needle held within a first needle hub of the connecting body and a second needle fixed within a second needle hub of the connecting body. A recess within the connecting body defining a reservoir. The reservoir containing at least one dose of a medicament and configured for fluid communication with the first needle. The connecting body further comprises a lockout feature that prevents the medicated module from being reconnected to the drug delivery device after the medicated module has been connected to the drug delivery device a first time.

This disclosure concerns systems and methods for tissue resection. Systems according to the various embodiments of the invention include cutting instruments, particularly laser cutting heads, and/or polymer materials that form polymer bodies when flowed into tissue.