The invention is related to a dispense interface (402) for a drug delivery device for delivering at least two drug agents, wherein the dispense interface (402) is configured to be coupled to a cartridge holder of the drug delivery device, wherein the cartridge holder is configured to hold at least two cartridges (416, 418), wherein the dispense interface (402) comprises at least two inlet channels (404, 406), each comprising a fluid inlet opening (408, 412), wherein each fluid inlet opening (408, 412) is configured to receive fluid from a respective cartridge of the at least two cartridges (416, 418) when the dispense interface (402) is axially coupled to the cartridge holder, an outlet channel (424) comprising a fluid outlet opening (426), a valve structure (420) configured to be selectively moved into any one of a plurality of positions, wherein in at least one position the valve structure (420) selectively permits or prevents fluid flow from any of the at least two inlet channels (404, 406) to the outlet channel (424). The invention is further related to a drug delivery device for delivering at least two drug agents comprising a dispense interface (402) of the aforementioned kind.

A system for mixing and delivering content is disclosed. The system includes an applicator, a needle assembly, and a micro seal. The applicator includes two component chambers separate from one another, each component chamber including at least one output port on a distal end thereof and an applicator hub disposed on a distal end of the applicator adjacent to the at least one output port of each component chamber. The needle assembly includes an elongate hollow stylet having a plurality of lumens therein and a needle hub having an interior cannula fluidly coupled to the elongate hollow stylet. The micro seal is disposed within the applicator hub. The micro seal is configured to receive the interior cannula of the needle hub to establish a fluid coupling between each of the two component chambers with a respective one of the lumens within the elongate hollow stylet.

A dedicated needle assembly (300) that can be attached only to a dedicated drug delivery device (400) is disclosed. The dedicated needle assembly (300) comprises a connecting body (320) extending from a distal end to a proximal end. A dedicated mechanical coupling (310) is configured at the proximal end of the connecting body (320). The dedicated mechanical coupling (310) forms a releasable connection to a distal end of the dedicated drug delivery device (400). The dedicated needle assembly (300) may comprise a medicated module or, alternatively, a non-medicated module. In one arrangement, the dedicated mechanical coupling (310) is integral with the dedicated needle assembly (300).

A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360 distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.

An injection catheter system is disclosed. The system includes a catheter defining a first pressure transfer lumen adapted to retain a pressure transfer material, an actuator at a proximal end of the catheter adapted to deliver a pressure from a proximal end to a distal end of the first pressure transfer lumen via the pressure transfer material, a distal section defining at least a first internal chamber adapted to retain a therapeutic gel component, at least a first plunger retained in the first internal chamber, and an injection port for delivering a therapeutic gel component into a treatment location from the first internal chamber when the actuator is used to deliver a pressure via the pressure transfer material to move the first plunger to deliver a therapeutic gel component through the injection port.

An injection device is provided with dual medicament chambers and a mixing pen needle assembly, whereby predetermined dosages of two medicaments can be provided to a mixing reservoir in the pen needle assembly and delivered simultaneously with the injection device.

A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.

A drug delivery device configured to provide a dose of a first medicament followed by a dose of a second medicament is disclosed. The device includes a main exterior body and an interior body. The device further includes a dual-chamber reservoir with (i) a first chamber holding the first medicament and (ii) a second chamber holding the second medicament. The device also includes a needle and a plunger. After activation of the device, the plunger is configured to (i) move the dual-chamber reservoir a given distance in a distal direction with respect to the interior body so that a distal end of the needle extends out of the interior body and (ii) after moving the dual-chamber reservoir the given distance, move in the distal direction with respect to the dual-chamber reservoir so as to eject from the needle the first medicament followed by the second medicament.

A method for reducing imperfection of gluteus including hyper diluting Radiesse filler with a saline solution, mixing the Radiesse filler with said saline solution to obtain a homogenous mixture, introducing a cannula into a subdermal area of a patient gluteus and administering the homogenous mixture into the subdermal area of a patient in 5-10 ml aliquots 2 cm squared retrograding surrounding an initial injection area. The homogenous mixture has a mix ratio of five parts of saline solution for each part of Radiesse filler. The cannula being introduced into the subdermal area through an entry point made by an 18 mm needle. The initial injection area is defined by an initial injection of 5 ml of the homogenous mixture into the subdermal area of the patient's gluteus. The present method is used to increase the volume, reshape and reduce imperfections of the patient's gluteus.

A surgical kit for providing a cryoprotective composition configured to be applied during cryotreatment of a patient includes: a first container containing a predetermined amount or volume of a biodegradable and/or bioerodible fluid agent; and a second container containing a predetermined amount or volume of a non-toxic cryoprotectant agent. The predetermined amount or volume of the of biodegradable and/or bioerodible fluid agent and the predetermined amount or volume of a non-toxic cryoprotectant agent are configured to be mixed together to form the cryoprotective composition in which a therapeutically effective amount of the cryoprotective composition deposited in a body space of the patient in proximity to the cryotreatment remains within at least a portion of the body space for a duration of the cryotreatment and at least a portion of a body tissue proximate to the body space is viable after the cryotreatment.