A guide wire with improved joining strength is provided. The guide wire includes a first wire and a second wire are solid-phase-joined to each other, the first wire and the second wire are made of a NiTi-based alloy. When a section of a crystal grain size is 1 m in a number-based particle size distribution of crystal grains of a metallographic structure of a joint surface between the first wire and the second wire, the frequency of the crystal grains having a mode particle size is 25% or more and the frequency of the crystal grains having a crystal grain size with a representative diameter of (mode particle size (m)1 m) or more and (mode particle size (m)+1 m) or less is 60% or more.

A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.

The invention provides for a steerable guidewire for insertion into a body cavity, characterized in that is comprises an elongated body defining a longitudinally-arranged lumen comprising i) a proximal end portion and ii) a distal end portion comprising a spatially reconfigurable portion and a tip; a pull wire located along said lumen and affixed to said distal end portion and to said proximal end; an actuation region located on said proximal end portion adapted to impart a tension force on the pull wire resulting in a compression force to the spatially reconfigurable region; and an intermediate region tubular element on said body located between said spatially reconfigurable portion and said proximal end.

The present disclosure relates to guidewire devices with an outer tube and a core. The distal section of the core extends into and is surrounded by the outer tube. One or more centering mechanisms are also disposed within the outer tube and are arranged to fill a portion of the annular space between the core and the inner surface of the tube. The one or more centering mechanisms thereby assist in keeping the distal section of the core axially aligned within the tube, which enables effective control of the device and minimizes undesirable whip movements of the guidewire.

The present invention relates to the technical field of medical devices, and in particular, to a developable interventional guidewire for hyperpolarized .sup.129Xe MRI and a preparation method thereof. The interventional guidewire includes a guidewire body, a cladding layer wrapped around a surface of the guidewire body, a Zn(II)-PDA modified layer adhered to a surface of the cladding layer, and a developing film layer coated on the Zn(II)-PDA modified layer. The Zn(II)-PDA modified layer is introduced on the guidewire body and, through activation treatment with 2-methylimidazole and solvothermal synthesis, a continuous and dense ZIF-8 film layer is prepared as the developing film layer for the hyperpolarized .sup.129Xe MRI.

A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.

A locking mechanism is provided including a proximal component including a distal end including a first spanning distance and a gap disposed between a material of the distal end defining the first spanning distance. A distal component is rotationally coupled with the proximal portion. The distal component includes a cavity including a distal end, the cavity rotationally coupled with the distal end of the proximal component. The cavity includes a second spanning distance of the distal end of the cavity. A rotation of the proximal component with respect to the distal component, or the distal component with respect to the proximal component, is configured to align a direction of the first spanning distance with a direction of the second spanning distance and diminish the gap of the proximal component.

Systems and methods are disclosed for selectively accessing a target blood vessel and facilitating the advancement of treatment devices within the neurovasculature. The method includes causing an elongate device to adopt one or more curved configurations, which advance a distal end of the device into a target vessel, while avoiding adverse interactions with the vessel walls. The elongate device includes at least one deflection mechanism for deflection a portion of the shaft. Once the elongate device is located within a vessel, the curved configurations may be used to employ active stabilizing features to allow one or more inner devices to advance through the vessel in a controlled manner. The elongate device may then track over the inner device, using an inner device as a rail. An inner device can also be used to aim towards a target vessel.

A guidewire is disclosed that includes a multi-edge profile configured to improve torque transmission and reduce frictional engagement during intravascular navigation. In some embodiments, the multi-edge profile includes a square cross-section twisted into a helical structure. In some embodiments, the helical configuration creates discrete peaks and valleys that minimize contact area with surrounding anatomical structures and catheter lumens, enhancing trackability and directional control. The guidewire may include variable pitch sections, polymer jackets, and hydrophilic coatings to further improve lubricity. In some embodiments, a method includes using the guidewire in combination with one or more catheters having textured inner surfaces to synergistically reduce drag and facilitate navigation through tortuous anatomy. In some embodiments, the system includes a diagnostic catheter that can be delivered to a tortuous pathway simultaneously with the catheter without the need for additional support catheters.

A guide wire-catheter assembly includes a catheter tube having a longitudinal channel, and a guide wire configured to be movable in the longitudinal channel. The catheter tube includes a bendable part near its distal end. The bendable part includes, in the circumferential direction of the catheter tube, a varying flexibility, such that exerting a longitudinal compression force in a proximal direction at a compression location distally of the distal end part results in bending of the bendable part. The guide wire includes an expandable part, where the expandable part is movable between a non-expanded position, in which a cross section of the expandable part is smaller than a smallest cross section of the longitudinal channel of the catheter tube and an expanded position. When the expandable part is in the non-expanded position, the guide wire can be moved completely in and out of the longitudinal channel of the catheter tube.