Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

The pulse applicator includes a first arm, including a first electrode, a second arm, including a second electrode, and a spacer. The first arm, the spacer, and the second arm are movably connected, and define a gap between the first arm and the second arm. The first electrode, the gap, and the second electrode are selectively alignable, and the first electrode and the second electrode are configured to deliver an electrical field across the gap in response to an electrical pulse received across the first and second electrodes.

An electrotherapeutic device for treating a visual disease using microcurrent stimulation is provided. The device includes a signal generator in which a waveform controller digitally controls a waveform signal source so as to generate a waveform in which one or more waveform parameters (e.g., pulse width, pulse period, pulse position, pulse coding, peak current amplitude, duty cycle, and/or pulse shape) are varied in accordance with a protocol for treating a visual disease. The device also includes an applicator connected to the signal generator and configured to apply the waveform to at least one stimulation point within an eye region.

A method for treating diagnosed or suspected tumors of a subject, comprising obtaining a target map that identifies an actual or likely location of the tumor in the subject, and providing multifocal non-invasive electrical stimulation with a duration, spatiotemporal pattern, current intensity, electrode montage, and/or regimen sufficient to do one or more of the following: (1) reduce the size of one or more tumor(s), (2) alter its/their perfusion, (3) change its/their metabolic or electrical activity, (4) change its/their functional connectivity profile, (5) slow down or stop its/their progression/spread and related symptomatology, (6) characterize one or more tumor(s) based on its/their response to noninvasive brain stimulation; possibly in conjunction with optimized anatomical changes applied to the skin or skull to better steer currents and fields into the tumor.

The present invention is directed to an electrode system for recording nerve action potential (NAP) from surgically exposed nerve and methods for using such an electrode system. Electrophysiological methods are used during repair surgery of peripheral nerve trauma (PNT). PNT is a major medical problem with an annual incidence similar to that of epilepsy. Surgical intervention is provided based on the severity of nerve injury which is determined preoperatively and intraoperatively mainly by electrophysiological assessments. Among those, intraoperative nerve action potential (NAP) or compound action potential (CNAP) recording is preferred for direct assessment of functional continuity of the nerve.

Bacteria, cancer cells, fungus and other harmful cells located beneath the surface of a mammal body can be effectively destroyed by passing an electrical current through the area to be treated. Electrodes are positioned on either side of the area to be treated, for example, gums, fingers, arms, legs, feet and torso, and an electric current is caused to flow between the electrodes and through the area to be treated. The electric current will destroy the bacteria, cancer cells, fungus or other harmful cells.

Described herein are methods and apparatuses for the application of electric energy treatment(s) to skin tissue to alter pigmentation, and in particular to remove a tattoo. These methods and apparatuses may deliver pulsed electrical energy having a pulse duration in submicrosecond pulse range to provide high-field strength pulses that may effectively release tattoo ink and allow removal of tattoo ink regardless of ink color or composition.

Described is a low voltage, pulsed electrical stimulation device for upregulating expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.

Described herein are devices for applying an alternating electric field to a living subject or an in vitro medium at a frequency between 100 kHz and 500 kHz. Also described herein are methods of using the described devices for applying an AC electric field to a target region comprising rapidly dividing cells, e.g., cells associated with a variety of disorders or conditions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

A plasma treatment device (1) designed to treat a surface with a dielectrically impeded plasma, having a base body (3) that has at least one flat treatment side (5) facing the surface to be treated, and having an electrode arrangement (9) that has at least one electrode (7) and having a dielectric that completely covers the at least one electrode (7) in the direction of the surface to be treated, and having a line arrangement comprising at least one high-voltage supply line (13, 13a, 13b), wherein the electrode (7) is connected to the line arrangement and is able to be supplied, via the high-voltage supply line (13, 13a, 13b), with a high-voltage signal able to be applied to the high-voltage supply line (13, 13a, 13b), and having a nub arrangement (15) arranged on the treatment side (5) of the base body (3) and that has a multiplicity of nubs (17), makes it possible to easily combine an effective plasma treatment with an effective mechanical treatment of the surface to be treated in that the at least one electrode (7) of the electrode arrangement (9) extends into at least one nub (17) of the nub arrangement (15).