A fully implanted integrated, wireless, flexible CMOS chip for long-term recording and stimulation of the brain in vivo and methods of manufacturing thereof are provided. The chip is an entire biocompatible system and can include the dense surface electrode array, the underlying CMOS integrated circuit architecture, integrated wireless powering and telemetry. Furthermore, miniaturization through manufacturing, permits implantation of the chip under the skull and other regions of interest with no wires or connections. Furthermore, these devices and systems can operate under a dual modality such as to be able to record and stimulate the surface of the brain and/or tissue in which they have been implanted.

Cortical network structure that mediates response to brain stimulation, and associated systems and methods are disclosed herein. In one embodiment, a method for brain stimulation includes: delivering an input stimulus to an area of the brain, via a cortical implant; in response to delivering the input stimulus, generating neural signals in the brain; and generating a predicted outcome of the input stimulus. The predicted outcome is based on a set of data derived from a model that combines: protocol features that are brain agnostic, and network features that are based on interactions between neural nodes of the brain.

A flexible implantable electrode array is disclosed, comprising: a shank formed from a flexible polymer material. In an example embodiment, the shank comprises: a waveguide; and a number of chipsets disposed in the shank along the length of the shank, wherein each chipset is configured to measure neural activity in tissue surrounding the shank near the respective chipset, and to communicate signals representative of the measured neural activity via the waveguide. A method for powering and receiving neuronal information from a flexible implantable electrode array comprises: wirelessly communicating power and commands from a backplane to a plurality of chipsets disposed along the length of a shank via a waveguide disposed within the shank; monitoring neural activity proximate each chipset and sending a signal representative of said neural activity from the corresponding chipset transceiver to the backplane via the waveguide.

Disclosed are devices, electrodes, systems, methods, and other implementations, including a subdural sound that includes an elongated body configured to be placed within a subdural space of a brain area of a patient, with the elongated body defining a receiving channel to receive a displaceable electrode to be tangentially placed at a target site in the subdural space. The subdural sound further includes a curved tip at a distal end of the elongated body, the curved tip configured for angled insertion into the subdural space of the patient to advance the elongated body to the target site in the subdural space.

The present invention relates to an electrode, which is an in vivo insertable electrode, including a substrate, an electrically conductive layer formed on the substrate, a platinum black layer formed on the electrically conductive layer, a self-assembled monolayer (SAM) formed on the platinum black layer, and a lubricant layer formed on the SAM, a method of manufacturing the electrode, and a medical device including the electrode. The in vivo insertable electrode according to the present invention provides excellent electrical properties such as low impedance. Further, it shows that friction with tissue occurring when the electrode is inserted is reduced, and trauma during insertion and an immune rejection response after insertion is suppressed. Further, in the long term, it is possible to detect signals with high sensitivity throughout the entire period by preventing bioadhesion of in vivo cells, such as immune cells, and other proteins.

A subdural sensor includes: a substrate formed of a flexible material; and at least one type of sensor part mounted on the substrate. The substrate has an elongated shape, and includes: a sensor area in which the sensor part is mounted and a wiring pattern connected to the sensor part is formed; a wiring area contiguous with the sensor area, the wiring pattern extending in the wiring area; and a connector area contiguous with the wiring area, the connector area being an area on which a connector to be connected to the wiring pattern extending from the wiring area is mounted. A tip part of the sensor area has a planar shape that curves convexly toward an outer periphery, and a side shape that curves toward a first surface, the first surface being on the side of a dura mater when the subdural sensor is inserted into the subdural space.

Brain drainage device having a rod-shaped hollow body with an inner drainage channel for insertion through the cranium into the brain, a first sensor arrangement with at least one sensor for measuring a physical parameter, and a signal interface; wherein the rod-shaped hollow body has a first region A which, in the applied state, is designed to protrude into the ventricle situated in the brain; wherein the rod-shaped hollow body has a second region B, which is arranged proximally from the first region, wherein the second region is designed to lie in the region of the brain mass in the applied state; wherein the first sensor arrangement is arranged in the second region in order to measure a physical parameter of the brain mass; wherein the first sensor arrangement is connected to the signal interface such that measurement data determined by the first sensor arrangement are transmitted to a measuring system that is to be connected.

A system provides a burr hole cap assembly configured to secure a position of a lead implanted through a burr hole in a cranium of a patient. One or more electrodes are coupled to one or more components of the burr hole cap assembly. The one or more electrode is disposed within the burr hole cap assembly for sensing signals within a brain of the patient or stimulating a portion of the brain of the patient.

A system provides a burr hole cap assembly configured to secure a position of a lead implanted through a burr hole in a cranium of a patient. One or more electrodes are coupled to one or more components of the burr hole cap assembly. The one or more electrode is disposed within the burr hole cap assembly for sensing signals within a brain of the patient or stimulating a portion of the brain of the patient.

Brain drainage device having a rod-shaped hollow body with an inner drainage channel for insertion through the cranium into the brain, a first sensor arrangement with at least one sensor for measuring a physical parameter, and a signal interface; wherein the rod-shaped hollow body has a first region A which configured to protrude into the ventricle situated in the brain; wherein the rod-shaped hollow body has a second region B, which is arranged proximally from the first region, wherein the second region is configured to lie in the region of the brain mass; wherein the first sensor arrangement is arranged in the second region in order to measure a physical parameter of the brain mass; wherein the first sensor arrangement is connected to the signal interface such that measurement data determined by the first sensor arrangement are transmitted to a measuring system.