A method of manufacturing a plurality of neural probes from a silicon wafer in which after neural probes are formed on one side of a silicon wafer, the other side of the silicon wafter is subject to a dicing process that separates and adjusts the thickness of the neural probes.

The present disclosure provides a three-dimensional micro-electrode that comprises an electrically conductive, elongate body with: a base that is electrically connectible to a recording system; a tip that is opposite the base and that is configured to establish electrical communication with an excitable cellular-network or a cell therein; and an elongate portion between the base and the tip. The elongate portion is covered with at least one layer of an electrical-insulator coating that extends from the base to proximal the tip. The present disclosure also provides a micro-electrode array comprising at least two three-dimensional micro-electrodes that are electrically connective to at least one recording system. The present disclosure also provides a method of making and using a three-dimensional micro-electrode and an array that comprises three-dimensional micro-electrodes.

The present disclosure provides systems and methods for selecting contacts for use in deep brain stimulation (DBS). A computing device includes a processor and a memory device communicatively coupled to the processor. The memory device includes instructions that, when executed, cause the processor to apply a spatial filter to local field potential (LFP) recordings for a plurality of contacts of a DBS lead, calculate a power spectral density (PSD) for each contact from the filtered LFP for that contact, calculate a parametric approximation for each PSD, select at least one frequency band based on the parametric approximations, calculate a spectral coherency matrix for each of the at least one selected frequency band, and calculate an eigenvector centrality for each spectral coherency matrix to facilitate identifying a contact for stimulation.

The invention relates to a hybrid intracerebral electrode comprising a narrow, elongated body intended to be implanted in the brain of a patient in order to carry out at least one multi-scale electroencephalographic exploration. Said hybrid intracerebral electrode comprises, in its active part, a plurality of first electrical contact elements forming stationary macro-contacts, and a plurality of second electrical contact elements forming movable micro-contacts. The hybrid intracerebral electrode is characterised by control means which are built into the electrode in a coupling tip integral with the body. The control means are designed to move the second electrical contact elements between a passive position in which same are retracted inside the body and an active position in which same protrude outside the body, and simultaneously to adjust the controlled projection length thereof with respect to the body of the electrode.

The invention relates to a hybrid intracerebral electrode comprising a narrow, elongated body intended to be implanted in the brain of a patient in order to carry out at least one multi-scale electroencephalographic exploration. Said hybrid intracerebral electrode comprises, in its active part, a plurality of first electrical contact elements forming stationary macro-contacts, and a plurality of second electrical contact elements forming movable micro-contacts. The hybrid intracerebral electrode is characterised by control means which are built into the electrode in a coupling tip integral with the body. The control means are designed to move the second electrical contact elements between a passive position in which same are retracted inside the body and an active position in which same protrude outside the body, and simultaneously to adjust the controlled projection length thereof with respect to the body of the electrode.

In some embodiments, there is provided an apparatus including a common bus and a plurality of oscillatrode circuits coupled to the common bus, the plurality of oscillatrode circuits including a first oscillatrode circuit outputting a first frequency tone when a first input voltage is detected by the first oscillatrode circuit and a second oscillatrode circuit outputting a second frequency tone when a second input voltage is detected by the second oscillatrode circuit, wherein common bus carries the first frequency tone and the second frequency tone at different frequencies in a frequency division multiplex signal. Related systems, methods, and articles of manufacture are also disclosed.

A preferred conformal penetrating multi electrode array includes a plastic substrate that is flexible enough to conform to cortical tissue. A plurality of penetrating semiconductor micro electrodes extend away from a surface of the flexible substrate and are stiff enough to penetrate cortical tissue. Electrode lines are encapsulated at least partially within the flexible substrate and electrically connected to the plurality of penetrating semiconductor microelectrodes. The penetrating semiconductor electrodes preferably include pointed metal tips. A preferred method of fabrication permits forming stiff penetrating electrodes on a substrate that is very flexible, and providing electrical connection to electrode lines within the substrate.

The invention provides a stepping doser. The doser comprises a bearing component, a dosing catheter, wiring tubes, a threaded rod, a nut, a signal recorder and a connecting rod; wherein the middle socket of the threaded rod is sheathed with a nut, the lower end of the threaded rod contacts the lower inner wall of the bearing component, the upper end of the threaded rod penetrates the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; The bearing component is also provided with a limit stop for limiting the rotation of the nut so that when the threaded rod rotates, the nut can move up and down; when the nut moves up and down, the dosing catheter can move up and down. The dosing catheter can be stepped with this doser, allowing dosing in a larger area.

An intraoperative multichannel brain probe is presented. The brain probe has a cylindrical upper stainless steel section attached to a lower cylindrical section. In the lower section, an outer cylindrical tube surrounds a second insulating tube. Electrically recording/stimulating wires are placed between the outer tube and the second tube. Each wire has one end protruding out a hole in the outer tube. The other end of each wire is threaded through the entire probe and electrically connected to a recording or stimulating device through a connector system. A number of insulating tubes and electrodes located inside the second tube may also be part of the brain probe. Each inner electrode, typically two, is insulated from each other and from the second insulating tube by other insulating tubes. The combination of one or more wires and electrodes provides a multi-functional device. The brain probe is capable of providing multichannel stimulation and/or recording of brain functions and up to 128 individual electrode conducting sites.

The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.