The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

This invention is directed to a bio-potential electrode-set for measuring electrical signals during an electrooculogram (EOG) from a human, particularly to flexible self-adhesive bio-potential sensing electrode-set substrate specifically to cover the perimeter of the eyes for EOG recordings. In general, EOG is a technique for measuring the cornea-retinal standing potential that exists between the front and the back of the human eye. The resulting signal is called the electrooculogram. Primary applications include, but are not limited to, ophthalmological assessments that require recording eye movements or gaze tracking and human computer/machine interfaces.

A wearable article includes: an annular casing that surrounds a space into which a body of a user is to be inserted; a light-emitting element that is provided in the casing, the light-emitting element emitting light towards the space; an imaging element that is provided in the casing, the imaging element capturing and obtaining an image of the space when the light-emitting element emits light; and an authentication circuit that authenticates the user based on a vein pattern obtained in advance and the image.

The present invention provides a wirelessly driven contact lens including a strain sensor capable of detecting an increase in intraocular pressure in real time and a drug reservoir capable of lowering the intraocular pressure by releasing a drug based on the increase in intraocular pressure. In the present invention, there may be provided a personal therapy system that measures intraocular pressure in real time and properly releases a therapeutic drug according to the intraocular pressure that is measured through the strain sensor and the drug reservoir for releasing a drug based on an intraocular pressure state of a glaucoma patient.

An ophthalmic lens having an electronic system is described herein for monitoring the medical condition of the wearer using at least one sensor and at least one problem template. In a further embodiment, the problem template includes a pattern and/or a threshold. In at least one embodiment, the lens works in conjunction with a second lens and/or an external device to monitor for a medical condition or to perform a test protocol of the wearer. Examples of the at least one sensor include an eyelid position sensor system, an eye movement sensor system, a biosensor, a bioimpedance sensor, a temperature sensor, and a pulse oximeter.

Methods and apparatus to charge biomedical devices are described. In some examples, a biometric-based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result and wherein the biomedical device is charged with a wireless charging system. In some examples, the charging system may beam energy to the biomedical device. In some examples, the charging system beams energy to the area surrounding the biomedical device.

a) A Gabor domain optical coherence microscopy (GD-OCM) system providing high resolution of structural and motion imaging of objects such as tissues is combined with the use of reverberant shear wave fields (RevSW) or longitudinal shear waves (LSW) and two novel mechanical excitation sources: a coaxial coverslip excitation (CCE) and a multiple pronged excitation (MPE) sources providing structured and controlled mechanical excitation in tissues and leading to accurate derivation of elastographic properties. Alternatively, general optical computed tomography (OCT) is combined with RevSW or LWC in the object to derive elastographic properties. The embodiments include (a) GD-OCM with RevSW; (b) GD-OCM with LSW; (c) General OCT with RevSW; and General OCT with LSW.

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

A plurality of methods and apparatus for managing deficiencies of the meibomian gland lipid production and delivery, including wearable fabrics configured with a matrix of micro- and nano-electromechanical materials, or composite fibres of yarn that are substantially made from carbon nanotubes, graphene, spider silk, natural silk, denim, cotton, metals, or combination thereof. Other methods and apparatus include infrared and ultrasound energy sources within a kit aimed at personalised therapies for improving overall health of the eyelids, while providing for adjunctive relief for associated dry eye symptoms. The management kit may comprise a wearable fabric or spectacle frame configured with infrared emitters and sensors, a handheld imaging device and software containing dosage and administration information coupled with information on improving eyelid hygiene which is reviewed and periodically updated using user-specific information.

A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.